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[Comparison of methods to detect insulin resistance in obese children and adolescents].
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2005 Jul; 34(4):316-9.ZD

Abstract

OBJECTIVE

To explore the practical and sensitive index for insulin resistance in obese children and adolescents.

METHODS

An oral glucose tolerance test and insulin releasing test were performed in 126 obese (divided into 3 groups according their BMI) and 25 normal children. The ratio of fasting plasma glucose to fasting plasma insulin (FBG/FINS), homeostasis model assessment-insulin resistance (HOMA-IR), homeostasis model assessment-insulin activity index (IAI), whole body insulin sensitivity index (WBISI) and area under curve of glucose and insulin (AUCBG, AUCINS) were calculated.

RESULT

There were no significant differences in fasting plasma glucose levels, while significant differences existed in fasting plasma insulin, the ratio of fasting plasma glucose to fasting plasma insulin,homeostasis model assessment-insulin resistance, homeostasis model assessment-insulin activity index, whole body insulin sensitivity index, area under curve of glucose, area under curve of insulin and AUCINS/AUCBG among these four groups. Whole body insulin sensitivity index (WBISI) reflected the sensitiveness of the insulin earlier than that of homeostasis model assessment-insulin resistance and homeostasis model assessment-insulin activity index.

CONCLUSION

Whole body insulin sensitivity index seems to be a better index for insulin resistance for obese children.

Authors+Show Affiliations

Department of Endocrinology, The Affiliated Children's Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

16059978

Citation

Wang, Chun-lin, et al. "[Comparison of Methods to Detect Insulin Resistance in Obese Children and Adolescents]." Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences, vol. 34, no. 4, 2005, pp. 316-9.
Wang CL, Liang L, Fu JF, et al. [Comparison of methods to detect insulin resistance in obese children and adolescents]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2005;34(4):316-9.
Wang, C. L., Liang, L., Fu, J. F., & Hong, F. (2005). [Comparison of methods to detect insulin resistance in obese children and adolescents]. Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences, 34(4), 316-9.
Wang CL, et al. [Comparison of Methods to Detect Insulin Resistance in Obese Children and Adolescents]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2005;34(4):316-9. PubMed PMID: 16059978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Comparison of methods to detect insulin resistance in obese children and adolescents]. AU - Wang,Chun-lin, AU - Liang,Li, AU - Fu,Jun-fen, AU - Hong,Fang, PY - 2005/8/2/pubmed PY - 2006/10/27/medline PY - 2005/8/2/entrez SP - 316 EP - 9 JF - Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences JO - Zhejiang Da Xue Xue Bao Yi Xue Ban VL - 34 IS - 4 N2 - OBJECTIVE: To explore the practical and sensitive index for insulin resistance in obese children and adolescents. METHODS: An oral glucose tolerance test and insulin releasing test were performed in 126 obese (divided into 3 groups according their BMI) and 25 normal children. The ratio of fasting plasma glucose to fasting plasma insulin (FBG/FINS), homeostasis model assessment-insulin resistance (HOMA-IR), homeostasis model assessment-insulin activity index (IAI), whole body insulin sensitivity index (WBISI) and area under curve of glucose and insulin (AUCBG, AUCINS) were calculated. RESULT: There were no significant differences in fasting plasma glucose levels, while significant differences existed in fasting plasma insulin, the ratio of fasting plasma glucose to fasting plasma insulin,homeostasis model assessment-insulin resistance, homeostasis model assessment-insulin activity index, whole body insulin sensitivity index, area under curve of glucose, area under curve of insulin and AUCINS/AUCBG among these four groups. Whole body insulin sensitivity index (WBISI) reflected the sensitiveness of the insulin earlier than that of homeostasis model assessment-insulin resistance and homeostasis model assessment-insulin activity index. CONCLUSION: Whole body insulin sensitivity index seems to be a better index for insulin resistance for obese children. SN - 1008-9292 UR - https://www.unboundmedicine.com/medline/citation/16059978/[Comparison_of_methods_to_detect_insulin_resistance_in_obese_children_and_adolescents]_ L2 - https://medlineplus.gov/obesityinchildren.html DB - PRIME DP - Unbound Medicine ER -