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Antioxidant effects of combined vitamins C and E in acute myocardial infarction. The randomized, double-blind, placebo controlled, multicenter pilot Myocardial Infarction and VITamins (MIVIT) trial.
Kardiol Pol. 2005 Apr; 62(4):344-50.KP

Abstract

AIMS

There is a large body of evidence that reactive oxygen species (ROS) produced during myocardial ischemia and reperfusion play a crucial role in myocardial damage and endothelial dysfunction. The MIVIT pilot trial was designed to test the effects of antioxidant vitamins C and E on the clinical outcome of patients with AMI.

METHODS AND RESULTS

In this randomized, double-blind, multicenter trial, 800 patients (mean age 62) with AMI were randomly allocated to receive, on top of routine medication, one of two treatments: vitamin C (1000 mg/12 h infusion) followed by 1200 mg/24 h orally and vitamin E (600 mg/24 h) or matching placebo for 30 days. Primary end point (composite of in-hospital cardiac mortality, non-fatal new myocardial infarction, VT/VF/asystole, shock/pulmonary edema) occurred less frequently in patients treated with antioxidants (55 [14%] vs 75 [19%], OR 0.82 [95% CI, 0.68-1.00], p=0.048).

CONCLUSIONS

This randomized pilot trial shows that supplementation with antioxidant vitamins is safe and seems to positively influence the clinical outcome of patients with AMI. A larger study is warranted to provide further evidence of this promising and inexpensive regimen.

Authors+Show Affiliations

Postgraduate Medical School, Department of Cardiology, Grochowski Hospital, Warsaw.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16059992

Citation

Jaxa-Chamiec, Tomasz, et al. "Antioxidant Effects of Combined Vitamins C and E in Acute Myocardial Infarction. the Randomized, Double-blind, Placebo Controlled, Multicenter Pilot Myocardial Infarction and VITamins (MIVIT) Trial." Kardiologia Polska, vol. 62, no. 4, 2005, pp. 344-50.
Jaxa-Chamiec T, Bednarz B, Drozdowska D, et al. Antioxidant effects of combined vitamins C and E in acute myocardial infarction. The randomized, double-blind, placebo controlled, multicenter pilot Myocardial Infarction and VITamins (MIVIT) trial. Kardiol Pol. 2005;62(4):344-50.
Jaxa-Chamiec, T., Bednarz, B., Drozdowska, D., Gessek, J., Gniot, J., Janik, K., Kawka-Urbanek, T., Maciejewski, P., Ogórek, M., & Szpajer, M. (2005). Antioxidant effects of combined vitamins C and E in acute myocardial infarction. The randomized, double-blind, placebo controlled, multicenter pilot Myocardial Infarction and VITamins (MIVIT) trial. Kardiologia Polska, 62(4), 344-50.
Jaxa-Chamiec T, et al. Antioxidant Effects of Combined Vitamins C and E in Acute Myocardial Infarction. the Randomized, Double-blind, Placebo Controlled, Multicenter Pilot Myocardial Infarction and VITamins (MIVIT) Trial. Kardiol Pol. 2005;62(4):344-50. PubMed PMID: 16059992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant effects of combined vitamins C and E in acute myocardial infarction. The randomized, double-blind, placebo controlled, multicenter pilot Myocardial Infarction and VITamins (MIVIT) trial. AU - Jaxa-Chamiec,Tomasz, AU - Bednarz,Bronisław, AU - Drozdowska,Dorota, AU - Gessek,Jacek, AU - Gniot,Jacek, AU - Janik,Krzysztof, AU - Kawka-Urbanek,Teresa, AU - Maciejewski,Paweł, AU - Ogórek,Michał, AU - Szpajer,Michał, AU - ,, PY - 2005/8/2/pubmed PY - 2005/9/21/medline PY - 2005/8/2/entrez SP - 344 EP - 50 JF - Kardiologia polska JO - Kardiol Pol VL - 62 IS - 4 N2 - AIMS: There is a large body of evidence that reactive oxygen species (ROS) produced during myocardial ischemia and reperfusion play a crucial role in myocardial damage and endothelial dysfunction. The MIVIT pilot trial was designed to test the effects of antioxidant vitamins C and E on the clinical outcome of patients with AMI. METHODS AND RESULTS: In this randomized, double-blind, multicenter trial, 800 patients (mean age 62) with AMI were randomly allocated to receive, on top of routine medication, one of two treatments: vitamin C (1000 mg/12 h infusion) followed by 1200 mg/24 h orally and vitamin E (600 mg/24 h) or matching placebo for 30 days. Primary end point (composite of in-hospital cardiac mortality, non-fatal new myocardial infarction, VT/VF/asystole, shock/pulmonary edema) occurred less frequently in patients treated with antioxidants (55 [14%] vs 75 [19%], OR 0.82 [95% CI, 0.68-1.00], p=0.048). CONCLUSIONS: This randomized pilot trial shows that supplementation with antioxidant vitamins is safe and seems to positively influence the clinical outcome of patients with AMI. A larger study is warranted to provide further evidence of this promising and inexpensive regimen. SN - 0022-9032 UR - https://www.unboundmedicine.com/medline/citation/16059992/Antioxidant_effects_of_combined_vitamins_C_and_E_in_acute_myocardial_infarction__The_randomized_double_blind_placebo_controlled_multicenter_pilot_Myocardial_Infarction_and_VITamins__MIVIT__trial_ L2 - https://medlineplus.gov/heartattack.html DB - PRIME DP - Unbound Medicine ER -