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The relationship between serum resistin, leptin, adiponectin, ghrelin levels and bone mineral density in middle-aged men.
Clin Endocrinol (Oxf). 2005 Aug; 63(2):131-8.CE

Abstract

OBJECTIVE

Body weight is a significant predictor of bone mass. Hormonal factors such as sex hormones, insulin, leptin and adiponectin are thought to play a role in the mechanisms controlling the association of body weight and fat mass with bone mass. However, contradictory results have been reported for the association between serum adipocytokines and bone mineral density (BMD). We therefore examined whether the serum adipocytokine and ghrelin levels, markers of fat metabolism, are associated with BMD in male adults.

PATIENTS AND MEASUREMENTS

For 80 male adults (average age 54.5 +/- 6.4 years; average body mass index (BMI) 24.4 +/- 2.5 kg/m2), the correlations between serum resistin, leptin, adiponectin and ghrelin levels with BMD were investigated.

RESULTS

Among the adipocytokines, serum resistin levels were negatively correlated with lumbar spine BMD (r = -0.237, P = 0.05). After adjustment was made for age and BMI, log-transformed serum leptin showed a significant negative correlation with lumbar spine BMD, which was not seen on bivariate analysis (r = -0.237, P = 0.039). Femoral neck BMD was marginally associated only with serum adiponectin levels (r = -0.226, P = 0.062). In multiple regression analyses, among the adipokines, only resistin was a significant determinant of lumbar spine BMD, although the variance was small (R2 = 0.256). Serum ghrelin levels were not correlated with the BMD of either body site.

CONCLUSIONS

Serum resistin level showed a significant negative correlation with lumbar spine BMD, although the variance was small. Further studies are needed to elucidate the role of adipocytokines in bone metabolism.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Department of Internal Medicine, Sacred Heart Hospital, Hallym University, Pyungchon-dong, Dongan-gu, Anyang-city, Kyungki-do, Chunchon, Korea. okwendo@yahoo.co.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16060905

Citation

Oh, Ki Won, et al. "The Relationship Between Serum Resistin, Leptin, Adiponectin, Ghrelin Levels and Bone Mineral Density in Middle-aged Men." Clinical Endocrinology, vol. 63, no. 2, 2005, pp. 131-8.
Oh KW, Lee WY, Rhee EJ, et al. The relationship between serum resistin, leptin, adiponectin, ghrelin levels and bone mineral density in middle-aged men. Clin Endocrinol (Oxf). 2005;63(2):131-8.
Oh, K. W., Lee, W. Y., Rhee, E. J., Baek, K. H., Yoon, K. H., Kang, M. I., Yun, E. J., Park, C. Y., Ihm, S. H., Choi, M. G., Yoo, H. J., & Park, S. W. (2005). The relationship between serum resistin, leptin, adiponectin, ghrelin levels and bone mineral density in middle-aged men. Clinical Endocrinology, 63(2), 131-8.
Oh KW, et al. The Relationship Between Serum Resistin, Leptin, Adiponectin, Ghrelin Levels and Bone Mineral Density in Middle-aged Men. Clin Endocrinol (Oxf). 2005;63(2):131-8. PubMed PMID: 16060905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between serum resistin, leptin, adiponectin, ghrelin levels and bone mineral density in middle-aged men. AU - Oh,Ki Won, AU - Lee,Won Young, AU - Rhee,Eun Jung, AU - Baek,Ki Hyun, AU - Yoon,Kun Ho, AU - Kang,Moo Il, AU - Yun,Eun Joo, AU - Park,Cheol Young, AU - Ihm,Sung Hee, AU - Choi,Moon Gi, AU - Yoo,Hyung Joon, AU - Park,Sung Woo, PY - 2005/8/3/pubmed PY - 2005/11/3/medline PY - 2005/8/3/entrez SP - 131 EP - 8 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 63 IS - 2 N2 - OBJECTIVE: Body weight is a significant predictor of bone mass. Hormonal factors such as sex hormones, insulin, leptin and adiponectin are thought to play a role in the mechanisms controlling the association of body weight and fat mass with bone mass. However, contradictory results have been reported for the association between serum adipocytokines and bone mineral density (BMD). We therefore examined whether the serum adipocytokine and ghrelin levels, markers of fat metabolism, are associated with BMD in male adults. PATIENTS AND MEASUREMENTS: For 80 male adults (average age 54.5 +/- 6.4 years; average body mass index (BMI) 24.4 +/- 2.5 kg/m2), the correlations between serum resistin, leptin, adiponectin and ghrelin levels with BMD were investigated. RESULTS: Among the adipocytokines, serum resistin levels were negatively correlated with lumbar spine BMD (r = -0.237, P = 0.05). After adjustment was made for age and BMI, log-transformed serum leptin showed a significant negative correlation with lumbar spine BMD, which was not seen on bivariate analysis (r = -0.237, P = 0.039). Femoral neck BMD was marginally associated only with serum adiponectin levels (r = -0.226, P = 0.062). In multiple regression analyses, among the adipokines, only resistin was a significant determinant of lumbar spine BMD, although the variance was small (R2 = 0.256). Serum ghrelin levels were not correlated with the BMD of either body site. CONCLUSIONS: Serum resistin level showed a significant negative correlation with lumbar spine BMD, although the variance was small. Further studies are needed to elucidate the role of adipocytokines in bone metabolism. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/16060905/The_relationship_between_serum_resistin_leptin_adiponectin_ghrelin_levels_and_bone_mineral_density_in_middle_aged_men_ L2 - https://doi.org/10.1111/j.1365-2265.2005.02312.x DB - PRIME DP - Unbound Medicine ER -