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Functional genome of the human pathogenic fungus Paracoccidioides brasiliensis.
FEMS Immunol Med Microbiol. 2005 Sep 01; 45(3):369-81.FI

Abstract

Paracoccidioides brasiliensis is a dimorphic and thermo-regulated fungus which is the causative agent of paracoccidioidomycosis, an endemic disease widespread in Latin America. Pathogenicity is assumed to be a consequence of the cellular differentiation process that this fungus undergoes from mycelium to yeast cells during human infection. In an effort to elucidate the molecular mechanisms involved in this process a network of Brazilian laboratories carried out a transcriptome project for both cell types. This review focuses on the data analysis yielding a comprehensive view of the fungal metabolism and the molecular adaptations during dimorphism in P. brasiliensis from analysis of 6022 groups, related to expressed genes, which were generated from both mycelium and yeast phases.

Authors+Show Affiliations

Departamento de Biologia Celular, Laboratório de Biologia Molecular, Instituto de Biologia, Universidade de Brasília. msueli@unb.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16061364

Citation

Felipe, Maria Sueli S., et al. "Functional Genome of the Human Pathogenic Fungus Paracoccidioides Brasiliensis." FEMS Immunology and Medical Microbiology, vol. 45, no. 3, 2005, pp. 369-81.
Felipe MS, Torres FA, Maranhão AQ, et al. Functional genome of the human pathogenic fungus Paracoccidioides brasiliensis. FEMS Immunol Med Microbiol. 2005;45(3):369-81.
Felipe, M. S., Torres, F. A., Maranhão, A. Q., Silva-Pereira, I., Poças-Fonseca, M. J., Campos, E. G., Moraes, L. M., Arraes, F. B., Carvalho, M. J., Andrade, R. V., Nicola, A. M., Teixeira, M. M., Jesuíno, R. S., Pereira, M., Soares, C. M., & Brígido, M. M. (2005). Functional genome of the human pathogenic fungus Paracoccidioides brasiliensis. FEMS Immunology and Medical Microbiology, 45(3), 369-81.
Felipe MS, et al. Functional Genome of the Human Pathogenic Fungus Paracoccidioides Brasiliensis. FEMS Immunol Med Microbiol. 2005 Sep 1;45(3):369-81. PubMed PMID: 16061364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional genome of the human pathogenic fungus Paracoccidioides brasiliensis. AU - Felipe,Maria Sueli S, AU - Torres,Fernando A G, AU - Maranhão,Andrea Q, AU - Silva-Pereira,Ildinete, AU - Poças-Fonseca,Marcio J, AU - Campos,Elida G, AU - Moraes,Lídia M P, AU - Arraes,Fabrício B M, AU - Carvalho,Maria José A, AU - Andrade,Rosângela V, AU - Nicola,André M, AU - Teixeira,Marcus M, AU - Jesuíno,Rosália S A, AU - Pereira,Maristela, AU - Soares,Célia M A, AU - Brígido,Marcelo M, PY - 2005/05/02/received PY - 2005/05/07/accepted PY - 2005/8/3/pubmed PY - 2005/11/3/medline PY - 2005/8/3/entrez SP - 369 EP - 81 JF - FEMS immunology and medical microbiology JO - FEMS Immunol Med Microbiol VL - 45 IS - 3 N2 - Paracoccidioides brasiliensis is a dimorphic and thermo-regulated fungus which is the causative agent of paracoccidioidomycosis, an endemic disease widespread in Latin America. Pathogenicity is assumed to be a consequence of the cellular differentiation process that this fungus undergoes from mycelium to yeast cells during human infection. In an effort to elucidate the molecular mechanisms involved in this process a network of Brazilian laboratories carried out a transcriptome project for both cell types. This review focuses on the data analysis yielding a comprehensive view of the fungal metabolism and the molecular adaptations during dimorphism in P. brasiliensis from analysis of 6022 groups, related to expressed genes, which were generated from both mycelium and yeast phases. SN - 0928-8244 UR - https://www.unboundmedicine.com/medline/citation/16061364/Functional_genome_of_the_human_pathogenic_fungus_Paracoccidioides_brasiliensis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0928-8244&date=2005&volume=45&issue=3&spage=369 DB - PRIME DP - Unbound Medicine ER -