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Family history of psychiatric illness as a risk factor for schizoaffective disorder: a Danish register-based cohort study.
Arch Gen Psychiatry. 2005 Aug; 62(8):841-8.AG

Abstract

BACKGROUND

Schizoaffective disorder may be related to both schizophrenia and bipolar disorders, but no population-based studies, to our knowledge, have investigated this association in families.

OBJECTIVES

To determine whether a psychiatric history of schizoaffective disorder, bipolar disorder, or schizophrenia among parents and siblings is a risk factor for developing a schizoaffective disorder, and whether a specific pattern of family history of psychiatric illness exists in persons with schizoaffective disorder compared with persons with bipolar disorder or schizophrenia.

DESIGN

Register-based cohort study.

SETTING

Denmark.

COHORT

The 2.4 million persons born in Denmark after 1952.

MAIN OUTCOME MEASURES

Relative risks of the 3 illnesses estimated by Poisson regression.

RESULTS

In total, 1925 persons had a schizoaffective disorder, 3721 had a bipolar disorder, and 12 501 had schizophrenia. The relative risk of schizoaffective disorder was 2.76 (95% confidence interval, 2.49-3.06) if a first-degree relative had a history of mental illness compared with a person with no first-degree relatives with such a history. There was an additional risk (95% confidence interval) of 2.57 (2.11-3.13), 3.23 (2.63-3.95), or 1.92 (1.43-2.57) if the first-degree relative had schizophrenia, bipolar disorder, or schizoaffective disorder, respectively, compared with other psychiatric admissions. When bipolar disorder was the outcome, bipolar disorder in first-degree relatives was by far the significantly strongest risk factor. When schizophrenia was the outcome, the significantly strongest risk factor was schizophrenia among first-degree relatives.

CONCLUSION

Schizoaffective disorder is not simply a subgroup of either bipolar disorder or schizophrenia but may be genetically linked to both, with schizoaffective disorder being a subtype of each or a genetic intermediate form.

Authors+Show Affiliations

National Centre for Register-Based Research, University of Aarhus, Taasingegade 1, DK-8000 Aarhus C, Denmark. tml@ncrr.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16061761

Citation

Laursen, Thomas Munk, et al. "Family History of Psychiatric Illness as a Risk Factor for Schizoaffective Disorder: a Danish Register-based Cohort Study." Archives of General Psychiatry, vol. 62, no. 8, 2005, pp. 841-8.
Laursen TM, Labouriau R, Licht RW, et al. Family history of psychiatric illness as a risk factor for schizoaffective disorder: a Danish register-based cohort study. Arch Gen Psychiatry. 2005;62(8):841-8.
Laursen, T. M., Labouriau, R., Licht, R. W., Bertelsen, A., Munk-Olsen, T., & Mortensen, P. B. (2005). Family history of psychiatric illness as a risk factor for schizoaffective disorder: a Danish register-based cohort study. Archives of General Psychiatry, 62(8), 841-8.
Laursen TM, et al. Family History of Psychiatric Illness as a Risk Factor for Schizoaffective Disorder: a Danish Register-based Cohort Study. Arch Gen Psychiatry. 2005;62(8):841-8. PubMed PMID: 16061761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Family history of psychiatric illness as a risk factor for schizoaffective disorder: a Danish register-based cohort study. AU - Laursen,Thomas Munk, AU - Labouriau,Rodrigo, AU - Licht,Rasmus W, AU - Bertelsen,Aksel, AU - Munk-Olsen,Trine, AU - Mortensen,Preben Bo, PY - 2005/8/3/pubmed PY - 2005/8/24/medline PY - 2005/8/3/entrez SP - 841 EP - 8 JF - Archives of general psychiatry JO - Arch Gen Psychiatry VL - 62 IS - 8 N2 - BACKGROUND: Schizoaffective disorder may be related to both schizophrenia and bipolar disorders, but no population-based studies, to our knowledge, have investigated this association in families. OBJECTIVES: To determine whether a psychiatric history of schizoaffective disorder, bipolar disorder, or schizophrenia among parents and siblings is a risk factor for developing a schizoaffective disorder, and whether a specific pattern of family history of psychiatric illness exists in persons with schizoaffective disorder compared with persons with bipolar disorder or schizophrenia. DESIGN: Register-based cohort study. SETTING: Denmark. COHORT: The 2.4 million persons born in Denmark after 1952. MAIN OUTCOME MEASURES: Relative risks of the 3 illnesses estimated by Poisson regression. RESULTS: In total, 1925 persons had a schizoaffective disorder, 3721 had a bipolar disorder, and 12 501 had schizophrenia. The relative risk of schizoaffective disorder was 2.76 (95% confidence interval, 2.49-3.06) if a first-degree relative had a history of mental illness compared with a person with no first-degree relatives with such a history. There was an additional risk (95% confidence interval) of 2.57 (2.11-3.13), 3.23 (2.63-3.95), or 1.92 (1.43-2.57) if the first-degree relative had schizophrenia, bipolar disorder, or schizoaffective disorder, respectively, compared with other psychiatric admissions. When bipolar disorder was the outcome, bipolar disorder in first-degree relatives was by far the significantly strongest risk factor. When schizophrenia was the outcome, the significantly strongest risk factor was schizophrenia among first-degree relatives. CONCLUSION: Schizoaffective disorder is not simply a subgroup of either bipolar disorder or schizophrenia but may be genetically linked to both, with schizoaffective disorder being a subtype of each or a genetic intermediate form. SN - 0003-990X UR - https://www.unboundmedicine.com/medline/citation/16061761/Family_history_of_psychiatric_illness_as_a_risk_factor_for_schizoaffective_disorder:_a_Danish_register_based_cohort_study_ L2 - https://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/archpsyc.62.8.841 DB - PRIME DP - Unbound Medicine ER -