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Correlation between serum levels of free light chain and phenotype of plasma cells in bone marrow in primary AL amyloidosis.
Amyloid. 2005 Mar; 12(1):33-40.A

Abstract

To investigate whether there is a correlation between subtypes of plasma cells in the bone marrow and the production of M-protein, flow cytometry and serum free light chain (FLC) analyses were carried out in 17 patients with primary systemic AL amyloidosis (mean age, 59.9+/-8.8 years) and controls with M-protein (MGUS controls, n=6) and without it (negative controls, n=9). The patients showed a significantly higher value in the serum predominant FLC:serum creatinine ratio (43.8+/-63.2) and CD38++ CD19- CD56+ subpopulation (monoclonal plasma cells) (2.57+/-5.35%) than either the negative (p<0.0005 and p<0.001, respectively) or MGUS controls (p<0.05). With respect to maturation of plasma cells in the bone marrow, the intermediate (MPC-1+ CD45- CD49e-) and mature (MPC-1+ CD45+ CD49e-) subtypes were significantly higher (49.2+/-23.2%, p<0.005) and lower (27.6+/-21.3%, p<0.005) in the patients than in the negative controls, respectively. The serum predominant FLC:serum creatinine ratio was elevated in parallel with an increase in CD38++ CD19- CD56+ and MPC-1+ CD45- CD49e- cells and a decrease in mature subtypes (MPC-1+ CD45+ CD49e- and MPC-1+ CD45+ CD49e+ cells), There was a significantly positive correlation between the serum predominant FLC:serum creatinine ratio and either CD38++ CD19- CD56+ (r=0.510, p<0.05) or MPC-1+ CD45- CD49e- cells (r=0.481, p<0.05). In primary AL amyloidosis M-protein is probably produced by increased monoclonal plasma cells in the bone marrow, particularly by the intermediate subpopulation with a phenotype of MPC-1+ CD45- CD49e-.

Authors+Show Affiliations

Third Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16076609

Citation

Shimojima, Yasuhiro, et al. "Correlation Between Serum Levels of Free Light Chain and Phenotype of Plasma Cells in Bone Marrow in Primary AL Amyloidosis." Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis, vol. 12, no. 1, 2005, pp. 33-40.
Shimojima Y, Matsuda M, Gono T, et al. Correlation between serum levels of free light chain and phenotype of plasma cells in bone marrow in primary AL amyloidosis. Amyloid. 2005;12(1):33-40.
Shimojima, Y., Matsuda, M., Gono, T., Ishii, W., Fushimi, T., Hoshii, Y., Yamada, T., & Ikeda, S. (2005). Correlation between serum levels of free light chain and phenotype of plasma cells in bone marrow in primary AL amyloidosis. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis, 12(1), 33-40.
Shimojima Y, et al. Correlation Between Serum Levels of Free Light Chain and Phenotype of Plasma Cells in Bone Marrow in Primary AL Amyloidosis. Amyloid. 2005;12(1):33-40. PubMed PMID: 16076609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation between serum levels of free light chain and phenotype of plasma cells in bone marrow in primary AL amyloidosis. AU - Shimojima,Yasuhiro, AU - Matsuda,Masayuki, AU - Gono,Takahisa, AU - Ishii,Wataru, AU - Fushimi,Tomohisa, AU - Hoshii,Yoshinobu, AU - Yamada,Toshiyuki, AU - Ikeda,Shu-Ichi, PY - 2005/8/4/pubmed PY - 2005/9/15/medline PY - 2005/8/4/entrez SP - 33 EP - 40 JF - Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis JO - Amyloid VL - 12 IS - 1 N2 - To investigate whether there is a correlation between subtypes of plasma cells in the bone marrow and the production of M-protein, flow cytometry and serum free light chain (FLC) analyses were carried out in 17 patients with primary systemic AL amyloidosis (mean age, 59.9+/-8.8 years) and controls with M-protein (MGUS controls, n=6) and without it (negative controls, n=9). The patients showed a significantly higher value in the serum predominant FLC:serum creatinine ratio (43.8+/-63.2) and CD38++ CD19- CD56+ subpopulation (monoclonal plasma cells) (2.57+/-5.35%) than either the negative (p<0.0005 and p<0.001, respectively) or MGUS controls (p<0.05). With respect to maturation of plasma cells in the bone marrow, the intermediate (MPC-1+ CD45- CD49e-) and mature (MPC-1+ CD45+ CD49e-) subtypes were significantly higher (49.2+/-23.2%, p<0.005) and lower (27.6+/-21.3%, p<0.005) in the patients than in the negative controls, respectively. The serum predominant FLC:serum creatinine ratio was elevated in parallel with an increase in CD38++ CD19- CD56+ and MPC-1+ CD45- CD49e- cells and a decrease in mature subtypes (MPC-1+ CD45+ CD49e- and MPC-1+ CD45+ CD49e+ cells), There was a significantly positive correlation between the serum predominant FLC:serum creatinine ratio and either CD38++ CD19- CD56+ (r=0.510, p<0.05) or MPC-1+ CD45- CD49e- cells (r=0.481, p<0.05). In primary AL amyloidosis M-protein is probably produced by increased monoclonal plasma cells in the bone marrow, particularly by the intermediate subpopulation with a phenotype of MPC-1+ CD45- CD49e-. SN - 1350-6129 UR - https://www.unboundmedicine.com/medline/citation/16076609/Correlation_between_serum_levels_of_free_light_chain_and_phenotype_of_plasma_cells_in_bone_marrow_in_primary_AL_amyloidosis_ L2 - http://www.tandfonline.com/doi/full/10.1080/02772240500032515 DB - PRIME DP - Unbound Medicine ER -