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The abortifacient effects from the seeds of Coix lachryma-jobi L. var. ma-yuen Stapf.
J Toxicol Environ Health A. 2005 Sep; 68(17-18):1557-65.JT

Abstract

This study evaluated the abortifacient effects of the extracts of seeds of Coix lachryma-jobi L. var. ma-yuen Stapf (adlay) in pregnant rats. Pregnant rats were treated with oral administration of adlay seed extracts on d 6 of pregnancy and their fetuses were examined for growth and malformations on d 20 of pregnancy. Following oral administration of 1 g/kg body weight of water extracts but not methanolic extracts, fetal resorptions were significantly increased and mortality of postimplantation was increased. There were no significant differences in the uterine and fetal weight compared to control. Fetal malformations were not observed in the adlay seed extracts-treated pregnant rats. The contractile activity of uteri isolated from rats on d 20 of pregnancy was assessed. The spontaneous uterine contractions were significantly enhanced in rats treated with water extracts of adlay seeds (1 g/kg body weight). Immunoblotting of uteri from rats treated with water extracts of adlay seeds demonstrated an induction of cyclooxygenase-2 (COX-2) protein expression. The water extracts of adlay seeds also enhanced extracellular signal-regulated protein kinase (ERK) 1/2 phosphorylation and protein kinase C (PKC)-alpha translocation from cytosolic to particulate fractions in uteri. These results indicate that the water extracts of adlay seeds are capable of inducing embryotoxicity and enhancing uterine contractility during pregnancy. The enhanced activities of PKC-alpha, ERK1/2, and COX-2 may contribute to these responses.

Authors+Show Affiliations

Tzeng HP
Institute of Toxicology, College of Medicine, National Taiwan University, Taipei.
Chiang W
No affiliation info available
Ueng TH
No affiliation info available
Liu SH
No affiliation info available

MeSH

Abortifacient AgentsAnimalsCoixCyclooxygenase 1Cyclooxygenase 2Drugs, Chinese HerbalFemaleFetal DevelopmentFetal ResorptionMembrane ProteinsMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3PhosphorylationPregnancyProstaglandin-Endoperoxide SynthasesProtein Kinase CProtein Kinase C-alphaRatsRats, WistarSeedsUterine ContractionUterus

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16076766

Citation

Tzeng, Hui-Ping, et al. "The Abortifacient Effects From the Seeds of Coix Lachryma-jobi L. Var. Ma-yuen Stapf." Journal of Toxicology and Environmental Health. Part A, vol. 68, no. 17-18, 2005, pp. 1557-65.
Tzeng HP, Chiang W, Ueng TH, et al. The abortifacient effects from the seeds of Coix lachryma-jobi L. var. ma-yuen Stapf. J Toxicol Environ Health A. 2005;68(17-18):1557-65.
Tzeng, H. P., Chiang, W., Ueng, T. H., & Liu, S. H. (2005). The abortifacient effects from the seeds of Coix lachryma-jobi L. var. ma-yuen Stapf. Journal of Toxicology and Environmental Health. Part A, 68(17-18), 1557-65.
Tzeng HP, et al. The Abortifacient Effects From the Seeds of Coix Lachryma-jobi L. Var. Ma-yuen Stapf. J Toxicol Environ Health A. 2005;68(17-18):1557-65. PubMed PMID: 16076766.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The abortifacient effects from the seeds of Coix lachryma-jobi L. var. ma-yuen Stapf. AU - Tzeng,Hui-Ping, AU - Chiang,Wenchang, AU - Ueng,Tzuu-Huei, AU - Liu,Shing-Hwa, PY - 2005/8/4/pubmed PY - 2005/10/7/medline PY - 2005/8/4/entrez SP - 1557 EP - 65 JF - Journal of toxicology and environmental health. Part A JO - J Toxicol Environ Health A VL - 68 IS - 17-18 N2 - This study evaluated the abortifacient effects of the extracts of seeds of Coix lachryma-jobi L. var. ma-yuen Stapf (adlay) in pregnant rats. Pregnant rats were treated with oral administration of adlay seed extracts on d 6 of pregnancy and their fetuses were examined for growth and malformations on d 20 of pregnancy. Following oral administration of 1 g/kg body weight of water extracts but not methanolic extracts, fetal resorptions were significantly increased and mortality of postimplantation was increased. There were no significant differences in the uterine and fetal weight compared to control. Fetal malformations were not observed in the adlay seed extracts-treated pregnant rats. The contractile activity of uteri isolated from rats on d 20 of pregnancy was assessed. The spontaneous uterine contractions were significantly enhanced in rats treated with water extracts of adlay seeds (1 g/kg body weight). Immunoblotting of uteri from rats treated with water extracts of adlay seeds demonstrated an induction of cyclooxygenase-2 (COX-2) protein expression. The water extracts of adlay seeds also enhanced extracellular signal-regulated protein kinase (ERK) 1/2 phosphorylation and protein kinase C (PKC)-alpha translocation from cytosolic to particulate fractions in uteri. These results indicate that the water extracts of adlay seeds are capable of inducing embryotoxicity and enhancing uterine contractility during pregnancy. The enhanced activities of PKC-alpha, ERK1/2, and COX-2 may contribute to these responses. SN - 1528-7394 UR - https://www.unboundmedicine.com/medline/citation/16076766/The_abortifacient_effects_from_the_seeds_of_Coix_lachryma_jobi_L__var__ma_yuen_Stapf_ DB - PRIME DP - Unbound Medicine ER -