Tags

Type your tag names separated by a space and hit enter

Age and hypertension related changes in genotypes of MTHFR 677C>T, 1298A>C and PON1 -108C>T SNPs in men with coronary artery disease (CAD).
J Physiol Pharmacol. 2005 Mar; 56 Suppl 2:65-75.JP

Abstract

The phenotypes of CAD related to arterial hypertension co-occurrence were analysed in 174 male patients and 117 control men for the associations with the polymorphisms of the MTHFR gene (677C>T and 1298A>C) and the PON1 gene (-108C>T) in relation to age at diagnosis (less or equal and more than 50 years). We noted the increased frequency of the three MTHFR genotypes: CC/AC, CT/AA and CC/CC in the CAD group (65.5%) in comparison to the control group (45.3%), corresponding to the 2.3-fold increased risk of CAD for men with these genotypes (95%CI (1.4-3.7); p=0.0005). The higher increase in risk of CAD was noted for the younger men (OR=3.6; 95%CI(1.6-8.3); p=0.002) and lower for the older (OR=1.8; 95%CI(1.0-3.4); p=0.03). In the normotensive men the greater impact on CAD risk had the homozygous genotypes; the 2.3-fold higher risk was associated with MTHFR CC/AC, CC/CC and TT/AA genotypes (95%CI(1.2-4.4); p=0.01). After adjustment for age, the association between CAD and MTHFR was significant only for the younger normotensive men (OR=2.8; 95%CI (1.0-8.0); p=0.04). Additionally, we found that the younger part of the control group was characterized by higher frequency of the low expression PON1 -108T allele and PON1 -108TT genotype (0.54 and 31.9% respectively) in comparison to the older men (0.41 and 17.1% respectively; p=0.03).

Authors+Show Affiliations

Institute of Human Genetics, Poznan, Poland. strauss@icpnet.plNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16077191

Citation

Strauss, E, et al. "Age and Hypertension Related Changes in Genotypes of MTHFR 677C>T, 1298A>C and PON1 -108C>T SNPs in Men With Coronary Artery Disease (CAD)." Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, vol. 56 Suppl 2, 2005, pp. 65-75.
Strauss E, Głuszek J, Pawlak AL. Age and hypertension related changes in genotypes of MTHFR 677C>T, 1298A>C and PON1 -108C>T SNPs in men with coronary artery disease (CAD). J Physiol Pharmacol. 2005;56 Suppl 2:65-75.
Strauss, E., Głuszek, J., & Pawlak, A. L. (2005). Age and hypertension related changes in genotypes of MTHFR 677C>T, 1298A>C and PON1 -108C>T SNPs in men with coronary artery disease (CAD). Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, 56 Suppl 2, 65-75.
Strauss E, Głuszek J, Pawlak AL. Age and Hypertension Related Changes in Genotypes of MTHFR 677C>T, 1298A>C and PON1 -108C>T SNPs in Men With Coronary Artery Disease (CAD). J Physiol Pharmacol. 2005;56 Suppl 2:65-75. PubMed PMID: 16077191.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age and hypertension related changes in genotypes of MTHFR 677C>T, 1298A>C and PON1 -108C>T SNPs in men with coronary artery disease (CAD). AU - Strauss,E, AU - Głuszek,J, AU - Pawlak,A L, PY - 2005/8/4/pubmed PY - 2007/12/14/medline PY - 2005/8/4/entrez SP - 65 EP - 75 JF - Journal of physiology and pharmacology : an official journal of the Polish Physiological Society JO - J Physiol Pharmacol VL - 56 Suppl 2 N2 - The phenotypes of CAD related to arterial hypertension co-occurrence were analysed in 174 male patients and 117 control men for the associations with the polymorphisms of the MTHFR gene (677C>T and 1298A>C) and the PON1 gene (-108C>T) in relation to age at diagnosis (less or equal and more than 50 years). We noted the increased frequency of the three MTHFR genotypes: CC/AC, CT/AA and CC/CC in the CAD group (65.5%) in comparison to the control group (45.3%), corresponding to the 2.3-fold increased risk of CAD for men with these genotypes (95%CI (1.4-3.7); p=0.0005). The higher increase in risk of CAD was noted for the younger men (OR=3.6; 95%CI(1.6-8.3); p=0.002) and lower for the older (OR=1.8; 95%CI(1.0-3.4); p=0.03). In the normotensive men the greater impact on CAD risk had the homozygous genotypes; the 2.3-fold higher risk was associated with MTHFR CC/AC, CC/CC and TT/AA genotypes (95%CI(1.2-4.4); p=0.01). After adjustment for age, the association between CAD and MTHFR was significant only for the younger normotensive men (OR=2.8; 95%CI (1.0-8.0); p=0.04). Additionally, we found that the younger part of the control group was characterized by higher frequency of the low expression PON1 -108T allele and PON1 -108TT genotype (0.54 and 31.9% respectively) in comparison to the older men (0.41 and 17.1% respectively; p=0.03). SN - 1899-1505 UR - https://www.unboundmedicine.com/medline/citation/16077191/Age_and_hypertension_related_changes_in_genotypes_of_MTHFR_677C>T_1298A>C_and_PON1__108C>T_SNPs_in_men_with_coronary_artery_disease__CAD__ L2 - https://medlineplus.gov/coronaryarterydisease.html DB - PRIME DP - Unbound Medicine ER -