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Central obesity as a major determinant of increased high-sensitivity C-reactive protein in metabolic syndrome.
Int J Obes (Lond). 2005 Dec; 29(12):1452-6.IJ

Abstract

INTRODUCTION

Traditional cardiovascular risk factors such as central obesity, high blood pressure and insulin resistance, all constituents of metabolic syndrome, have been associated with increased levels of C-reactive protein (CRP). Therefore, this marker of low-grade inflammation may play a major role in the pathogenesis of cardiovascular diseases. In this study, data from a representative sample of urban adults was used to evaluate the association between CRP and metabolic syndrome, accounting for the type and number of its constituents.

METHODS

Using random digit dialing, 1022 participants, aged 18-92 y, were selected. All participants completed a structured questionnaire comprising of information on social, demographic, behavioral and clinical aspects. Anthropometrics and blood pressure were recorded and a fasting blood sample collected. Metabolic syndrome was defined, according to the Third Report of the Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults, as the presence of three or more of the following characteristics: waist circumference greater than 102 cm in men and 88 cm in women; triglyceride levels > or = 150 mg/dl; high-density lipoprotein cholesterol levels < 40 mg/dl in men and < 50 mg/dl in women; blood pressure > or = 130/85 mm Hg; and serum glucose > or = 110 mg/dl. High-sensitivity CRP was assessed by immunonephelometric assay. After excluding 65 participants with CRP > or = 10 mg/l, 957 subjects (599 women and 358 men) remained for analysis. Geometric means were compared after adjustment for age, sex, alcohol consumption and smoking.

RESULTS

Higher mean levels of CRP (2.34 vs 1.36, P < 0.001) were observed when metabolic syndrome was present. Also, mean CRP levels were significantly higher in the presence of central obesity (2.45 vs 1.24, P < 0.001), high blood pressure (1.76 vs 1.12, P < 0.001), hypertriglyceridemia (2.17 vs 1.32, P < 0.001) and high fasting glucose (1.96 vs 1.46, P = 0.032). We found a significant increasing trend (P < 0.001) in mean levels of CRP as the number of features of metabolic syndrome increased. The major contributing features for high CRP levels were central obesity and high blood pressure.

CONCLUSIONS

Present data show that increasing severity of metabolic syndrome is associated with increasing CRP. Additionally, we found that central obesity and high blood pressure are the most important determinants of the low-grade chronic inflammation present in metabolic syndrome.

Authors+Show Affiliations

Department of Hygiene and Epidemiology, University of Porto Medical School, Alameda Professor Hernani Monteiro, Porto, Portugal. acsantos@med.up.ptNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16077717

Citation

Santos, A-C, et al. "Central Obesity as a Major Determinant of Increased High-sensitivity C-reactive Protein in Metabolic Syndrome." International Journal of Obesity (2005), vol. 29, no. 12, 2005, pp. 1452-6.
Santos AC, Lopes C, Guimarães JT, et al. Central obesity as a major determinant of increased high-sensitivity C-reactive protein in metabolic syndrome. Int J Obes (Lond). 2005;29(12):1452-6.
Santos, A. C., Lopes, C., Guimarães, J. T., & Barros, H. (2005). Central obesity as a major determinant of increased high-sensitivity C-reactive protein in metabolic syndrome. International Journal of Obesity (2005), 29(12), 1452-6.
Santos AC, et al. Central Obesity as a Major Determinant of Increased High-sensitivity C-reactive Protein in Metabolic Syndrome. Int J Obes (Lond). 2005;29(12):1452-6. PubMed PMID: 16077717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Central obesity as a major determinant of increased high-sensitivity C-reactive protein in metabolic syndrome. AU - Santos,A-C, AU - Lopes,C, AU - Guimarães,J T, AU - Barros,H, PY - 2005/8/4/pubmed PY - 2006/6/10/medline PY - 2005/8/4/entrez SP - 1452 EP - 6 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 29 IS - 12 N2 - INTRODUCTION: Traditional cardiovascular risk factors such as central obesity, high blood pressure and insulin resistance, all constituents of metabolic syndrome, have been associated with increased levels of C-reactive protein (CRP). Therefore, this marker of low-grade inflammation may play a major role in the pathogenesis of cardiovascular diseases. In this study, data from a representative sample of urban adults was used to evaluate the association between CRP and metabolic syndrome, accounting for the type and number of its constituents. METHODS: Using random digit dialing, 1022 participants, aged 18-92 y, were selected. All participants completed a structured questionnaire comprising of information on social, demographic, behavioral and clinical aspects. Anthropometrics and blood pressure were recorded and a fasting blood sample collected. Metabolic syndrome was defined, according to the Third Report of the Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults, as the presence of three or more of the following characteristics: waist circumference greater than 102 cm in men and 88 cm in women; triglyceride levels > or = 150 mg/dl; high-density lipoprotein cholesterol levels < 40 mg/dl in men and < 50 mg/dl in women; blood pressure > or = 130/85 mm Hg; and serum glucose > or = 110 mg/dl. High-sensitivity CRP was assessed by immunonephelometric assay. After excluding 65 participants with CRP > or = 10 mg/l, 957 subjects (599 women and 358 men) remained for analysis. Geometric means were compared after adjustment for age, sex, alcohol consumption and smoking. RESULTS: Higher mean levels of CRP (2.34 vs 1.36, P < 0.001) were observed when metabolic syndrome was present. Also, mean CRP levels were significantly higher in the presence of central obesity (2.45 vs 1.24, P < 0.001), high blood pressure (1.76 vs 1.12, P < 0.001), hypertriglyceridemia (2.17 vs 1.32, P < 0.001) and high fasting glucose (1.96 vs 1.46, P = 0.032). We found a significant increasing trend (P < 0.001) in mean levels of CRP as the number of features of metabolic syndrome increased. The major contributing features for high CRP levels were central obesity and high blood pressure. CONCLUSIONS: Present data show that increasing severity of metabolic syndrome is associated with increasing CRP. Additionally, we found that central obesity and high blood pressure are the most important determinants of the low-grade chronic inflammation present in metabolic syndrome. SN - 0307-0565 UR - https://www.unboundmedicine.com/medline/citation/16077717/Central_obesity_as_a_major_determinant_of_increased_high_sensitivity_C_reactive_protein_in_metabolic_syndrome_ L2 - http://dx.doi.org/10.1038/sj.ijo.0803035 DB - PRIME DP - Unbound Medicine ER -