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Sequence determination in aliphatic poly(ester amide)s by matrix-assisted laser desorption/ionization time-of-flight and time-of-flight/time-of-flight tandem mass spectrometry.
Rapid Commun Mass Spectrom. 2005; 19(17):2407-18.RC

Abstract

Poly(ester amide)s from dimethyl sebacate or sebacic acid and 2-aminoethanol or 4-amino-1-butanol were characterized by post-source decay matrix-assisted laser desorption/ionization time-of-flight (PSD-MALDI-TOF) and time-of-flight/time-of-flight tandem mass spectrometry (MALDI-TOF/TOF-MS/MS). Sodiated oligomers were selected as precursor ions for dissociation studies. PSD analysis was performed on dimethyl sebacate, dicarboxylic, carboxylic and amino alcohol, and diamino alcohol terminated oligomers. PSD-MALDI-TOF mass spectra yielded information on the fragmentation mechanisms of the poly(ester amide) chains, showing that the main cleavages proceed through a beta-hydrogen transfer rearrangement. MALDI-TOF/TOF-MS/MS provided structural information concerning ester/amide sequences in the polymer chains. As expected, together with the ions appearing in the PSD-MALDI mass spectrum, several new abundant fragment ions in the low-mass range are present in MALDI-TOF/TOF-MS/MS spectra. These new product ions proved to be diagnostic and made it possible to establish the presence of random sequences of ester and amide bonds in the poly(ester amide)s samples.

Authors+Show Affiliations

Istituto di Chimica e Tecnologia dei Polimeri, Consiglio Nazionale delle Ricerche, V.le A. Doria 6, 95125 Catania, Italy. prizzarelli@dipchi.unict.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16078301

Citation

Rizzarelli, Paola, et al. "Sequence Determination in Aliphatic Poly(ester Amide)s By Matrix-assisted Laser Desorption/ionization Time-of-flight and Time-of-flight/time-of-flight Tandem Mass Spectrometry." Rapid Communications in Mass Spectrometry : RCM, vol. 19, no. 17, 2005, pp. 2407-18.
Rizzarelli P, Puglisi C, Montaudo G. Sequence determination in aliphatic poly(ester amide)s by matrix-assisted laser desorption/ionization time-of-flight and time-of-flight/time-of-flight tandem mass spectrometry. Rapid Commun Mass Spectrom. 2005;19(17):2407-18.
Rizzarelli, P., Puglisi, C., & Montaudo, G. (2005). Sequence determination in aliphatic poly(ester amide)s by matrix-assisted laser desorption/ionization time-of-flight and time-of-flight/time-of-flight tandem mass spectrometry. Rapid Communications in Mass Spectrometry : RCM, 19(17), 2407-18.
Rizzarelli P, Puglisi C, Montaudo G. Sequence Determination in Aliphatic Poly(ester Amide)s By Matrix-assisted Laser Desorption/ionization Time-of-flight and Time-of-flight/time-of-flight Tandem Mass Spectrometry. Rapid Commun Mass Spectrom. 2005;19(17):2407-18. PubMed PMID: 16078301.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sequence determination in aliphatic poly(ester amide)s by matrix-assisted laser desorption/ionization time-of-flight and time-of-flight/time-of-flight tandem mass spectrometry. AU - Rizzarelli,Paola, AU - Puglisi,Concetto, AU - Montaudo,Giorgio, PY - 2005/8/4/pubmed PY - 2005/8/4/medline PY - 2005/8/4/entrez SP - 2407 EP - 18 JF - Rapid communications in mass spectrometry : RCM JO - Rapid Commun Mass Spectrom VL - 19 IS - 17 N2 - Poly(ester amide)s from dimethyl sebacate or sebacic acid and 2-aminoethanol or 4-amino-1-butanol were characterized by post-source decay matrix-assisted laser desorption/ionization time-of-flight (PSD-MALDI-TOF) and time-of-flight/time-of-flight tandem mass spectrometry (MALDI-TOF/TOF-MS/MS). Sodiated oligomers were selected as precursor ions for dissociation studies. PSD analysis was performed on dimethyl sebacate, dicarboxylic, carboxylic and amino alcohol, and diamino alcohol terminated oligomers. PSD-MALDI-TOF mass spectra yielded information on the fragmentation mechanisms of the poly(ester amide) chains, showing that the main cleavages proceed through a beta-hydrogen transfer rearrangement. MALDI-TOF/TOF-MS/MS provided structural information concerning ester/amide sequences in the polymer chains. As expected, together with the ions appearing in the PSD-MALDI mass spectrum, several new abundant fragment ions in the low-mass range are present in MALDI-TOF/TOF-MS/MS spectra. These new product ions proved to be diagnostic and made it possible to establish the presence of random sequences of ester and amide bonds in the poly(ester amide)s samples. SN - 0951-4198 UR - https://www.unboundmedicine.com/medline/citation/16078301/Sequence_determination_in_aliphatic_poly_ester_amide_s_by_matrix_assisted_laser_desorption/ionization_time_of_flight_and_time_of_flight/time_of_flight_tandem_mass_spectrometry_ L2 - https://doi.org/10.1002/rcm.2075 DB - PRIME DP - Unbound Medicine ER -
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