Tags

Type your tag names separated by a space and hit enter

Elevating bioavailability of cyclosporine a via encapsulation in artificial oil bodies stabilized by caleosin.
Biotechnol Prog. 2005 Jul-Aug; 21(4):1297-301.BP

Abstract

To elevate its bioavailability via oral administration, cyclosporine A (CsA), a hydrophobic drug, was either incorporated into olive oil directly or encapsulated in artificial oil bodies (AOBs) constituted with olive oil and phospholipid in the presence or absence of recombinant caleosin purified from Escherichia coli. The bioavailabilities of CsA in these formulations were assessed in Wistar rats in comparison with the commercial formulation, Sandimmun Neoral. Among these tests, CsA-loaded AOBs stabilized by the recombinant caleosin exhibited better bioavailability than the commercial formulation and possessed the highest maximum whole blood concentration (C(max)), 1247.4 +/- 106.8 ng/mL, in the experimental animals 4.3 +/- 0.7 h (t(max)) after oral administration. C(max) and the area under the plasma concentration-time curve (AUC(0-24)) were individually increased by 50.8% and 71.3% in the rats fed with caleosin-stabilized AOBs when compared with those fed with the reference Sandimmun Neoral. The results suggest that constitution of AOBs stabilized by caleosin may be a suitable technique to encapsulate hydrophobic drugs for oral administration.

Authors+Show Affiliations

Graduate institute of Biotechnology, National Chung-Hsing University, Taichung, Taiwan, and Department of Physiology, National Yang-Ming University, Medical College, Taipei, Taiwan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16080714

Citation

Chen, Miles C M., et al. "Elevating Bioavailability of Cyclosporine a Via Encapsulation in Artificial Oil Bodies Stabilized By Caleosin." Biotechnology Progress, vol. 21, no. 4, 2005, pp. 1297-301.
Chen MC, Wang JL, Tzen JT. Elevating bioavailability of cyclosporine a via encapsulation in artificial oil bodies stabilized by caleosin. Biotechnol Prog. 2005;21(4):1297-301.
Chen, M. C., Wang, J. L., & Tzen, J. T. (2005). Elevating bioavailability of cyclosporine a via encapsulation in artificial oil bodies stabilized by caleosin. Biotechnology Progress, 21(4), 1297-301.
Chen MC, Wang JL, Tzen JT. Elevating Bioavailability of Cyclosporine a Via Encapsulation in Artificial Oil Bodies Stabilized By Caleosin. Biotechnol Prog. 2005 Jul-Aug;21(4):1297-301. PubMed PMID: 16080714.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevating bioavailability of cyclosporine a via encapsulation in artificial oil bodies stabilized by caleosin. AU - Chen,Miles C M, AU - Wang,Jui-Ling, AU - Tzen,Jason T C, PY - 2005/8/6/pubmed PY - 2006/1/13/medline PY - 2005/8/6/entrez SP - 1297 EP - 301 JF - Biotechnology progress JO - Biotechnol Prog VL - 21 IS - 4 N2 - To elevate its bioavailability via oral administration, cyclosporine A (CsA), a hydrophobic drug, was either incorporated into olive oil directly or encapsulated in artificial oil bodies (AOBs) constituted with olive oil and phospholipid in the presence or absence of recombinant caleosin purified from Escherichia coli. The bioavailabilities of CsA in these formulations were assessed in Wistar rats in comparison with the commercial formulation, Sandimmun Neoral. Among these tests, CsA-loaded AOBs stabilized by the recombinant caleosin exhibited better bioavailability than the commercial formulation and possessed the highest maximum whole blood concentration (C(max)), 1247.4 +/- 106.8 ng/mL, in the experimental animals 4.3 +/- 0.7 h (t(max)) after oral administration. C(max) and the area under the plasma concentration-time curve (AUC(0-24)) were individually increased by 50.8% and 71.3% in the rats fed with caleosin-stabilized AOBs when compared with those fed with the reference Sandimmun Neoral. The results suggest that constitution of AOBs stabilized by caleosin may be a suitable technique to encapsulate hydrophobic drugs for oral administration. SN - 8756-7938 UR - https://www.unboundmedicine.com/medline/citation/16080714/Elevating_bioavailability_of_cyclosporine_a_via_encapsulation_in_artificial_oil_bodies_stabilized_by_caleosin_ L2 - https://doi.org/10.1021/bp050030b DB - PRIME DP - Unbound Medicine ER -