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8-O-Azeloyl-14-benzoylaconine: a new alkaloid from the roots of Aconitum karacolicum Rapcs and its antiproliferative activities.
Bioorg Med Chem. 2005 Dec 01; 13(23):6493-501.BM

Abstract

A new alkaloid of Aconitum karacolicum Rapcs, from the Ranunculaceae family, collected in Kirghizstan, was isolated from the roots of this plant, using a purification scheme based upon its in vitro antiproliferative properties against three human tumour cell lines in culture. Structural identification was performed using high resolution MS-MS mass spectrometry and (1)H, (13)C, 2D NOESY NMR spectroscopy analysis. This compound consists of a 14-benzoylaconine moiety substituted on C-8 by an azeloyl chain. It presents in vitro cytotoxicity with an IC(50) of about 10-20 microM, which warrants further investigation on its possible interest in cancer chemotherapy.

Authors+Show Affiliations

Laboratoire de Pharmacologie des Médicaments Anticancéreux, Institut Bergonié, Bordeaux, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16081293

Citation

Chodoeva, Ainura, et al. "8-O-Azeloyl-14-benzoylaconine: a New Alkaloid From the Roots of Aconitum Karacolicum Rapcs and Its Antiproliferative Activities." Bioorganic & Medicinal Chemistry, vol. 13, no. 23, 2005, pp. 6493-501.
Chodoeva A, Bosc JJ, Guillon J, et al. 8-O-Azeloyl-14-benzoylaconine: a new alkaloid from the roots of Aconitum karacolicum Rapcs and its antiproliferative activities. Bioorg Med Chem. 2005;13(23):6493-501.
Chodoeva, A., Bosc, J. J., Guillon, J., Decendit, A., Petraud, M., Absalon, C., Vitry, C., Jarry, C., & Robert, J. (2005). 8-O-Azeloyl-14-benzoylaconine: a new alkaloid from the roots of Aconitum karacolicum Rapcs and its antiproliferative activities. Bioorganic & Medicinal Chemistry, 13(23), 6493-501.
Chodoeva A, et al. 8-O-Azeloyl-14-benzoylaconine: a New Alkaloid From the Roots of Aconitum Karacolicum Rapcs and Its Antiproliferative Activities. Bioorg Med Chem. 2005 Dec 1;13(23):6493-501. PubMed PMID: 16081293.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 8-O-Azeloyl-14-benzoylaconine: a new alkaloid from the roots of Aconitum karacolicum Rapcs and its antiproliferative activities. AU - Chodoeva,Ainura, AU - Bosc,Jean-Jacques, AU - Guillon,Jean, AU - Decendit,Alain, AU - Petraud,Michel, AU - Absalon,Christelle, AU - Vitry,Christiane, AU - Jarry,Christian, AU - Robert,Jacques, Y1 - 2005/08/02/ PY - 2005/05/11/received PY - 2005/06/29/revised PY - 2005/07/01/accepted PY - 2005/8/6/pubmed PY - 2006/1/13/medline PY - 2005/8/6/entrez SP - 6493 EP - 501 JF - Bioorganic & medicinal chemistry JO - Bioorg Med Chem VL - 13 IS - 23 N2 - A new alkaloid of Aconitum karacolicum Rapcs, from the Ranunculaceae family, collected in Kirghizstan, was isolated from the roots of this plant, using a purification scheme based upon its in vitro antiproliferative properties against three human tumour cell lines in culture. Structural identification was performed using high resolution MS-MS mass spectrometry and (1)H, (13)C, 2D NOESY NMR spectroscopy analysis. This compound consists of a 14-benzoylaconine moiety substituted on C-8 by an azeloyl chain. It presents in vitro cytotoxicity with an IC(50) of about 10-20 microM, which warrants further investigation on its possible interest in cancer chemotherapy. SN - 0968-0896 UR - https://www.unboundmedicine.com/medline/citation/16081293/8_O_Azeloyl_14_benzoylaconine:_a_new_alkaloid_from_the_roots_of_Aconitum_karacolicum_Rapcs_and_its_antiproliferative_activities_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0968-0896(05)00615-2 DB - PRIME DP - Unbound Medicine ER -