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Repeated Catha edulis oral administration enhances the baseline aggressive behavior in isolated rats.
J Neural Transm (Vienna). 2006 May; 113(5):543-56.JN

Abstract

The effects of repeated oral administration of the psychostimulant plant, Catha edulis and its active principle, cathinone on rats were studied using isolation induced aggression paradigm. The behavioral responses were videotaped and scored later by offline data analyses. Rats were decapitated at the end of the behavioral experiment and in the relevant brain regions, monoamines were assessed. The results demonstrate that isolation of male rats produces a baseline aggression. Treatments with the psychostimulant plant, Catha edulis or commercial S-(--)-cathinone enhanced significantly: The locomotor activities and the baseline aggression behaviors compared with vehicle treated rats. Neurochemical correlates revealed a significant depletion of serotonin (5-HT) and its corresponding metabolites (5-HIAA) in both the anterior and posterior striatum. There was also a reduction in the level of homovanillic acid (HVA) in the hippocampus. Additionally, elevation of dopamine level was observed in the nucleus accumbens, especially, in those rats treated with Catha edulis extract. Cathinone, on the other hand, increased the level of HVA in the posterior striatum and decreased HVA in the nucleus accumbens. In conclusion, the present data demonstrate that repeated administration of Catha edulis or S-(--)-cathinone enhances aggression in rats, presumably by decreasing the level of serotonin and its corresponding metabolites. Besides, the data obtained do not rule out the involvement of dopamine in aggression behavior.

Authors+Show Affiliations

Department of Neuropharmacology, Zoological Institute, Faculty of Biology, University of Tuebingen, Tuebingen, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16082505

Citation

Banjaw, M Y., et al. "Repeated Catha Edulis Oral Administration Enhances the Baseline Aggressive Behavior in Isolated Rats." Journal of Neural Transmission (Vienna, Austria : 1996), vol. 113, no. 5, 2006, pp. 543-56.
Banjaw MY, Miczek K, Schmidt WJ. Repeated Catha edulis oral administration enhances the baseline aggressive behavior in isolated rats. J Neural Transm (Vienna). 2006;113(5):543-56.
Banjaw, M. Y., Miczek, K., & Schmidt, W. J. (2006). Repeated Catha edulis oral administration enhances the baseline aggressive behavior in isolated rats. Journal of Neural Transmission (Vienna, Austria : 1996), 113(5), 543-56.
Banjaw MY, Miczek K, Schmidt WJ. Repeated Catha Edulis Oral Administration Enhances the Baseline Aggressive Behavior in Isolated Rats. J Neural Transm (Vienna). 2006;113(5):543-56. PubMed PMID: 16082505.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Repeated Catha edulis oral administration enhances the baseline aggressive behavior in isolated rats. AU - Banjaw,M Y, AU - Miczek,K, AU - Schmidt,W J, Y1 - 2005/08/05/ PY - 2005/03/25/received PY - 2005/06/25/accepted PY - 2005/8/6/pubmed PY - 2006/9/20/medline PY - 2005/8/6/entrez SP - 543 EP - 56 JF - Journal of neural transmission (Vienna, Austria : 1996) JO - J Neural Transm (Vienna) VL - 113 IS - 5 N2 - The effects of repeated oral administration of the psychostimulant plant, Catha edulis and its active principle, cathinone on rats were studied using isolation induced aggression paradigm. The behavioral responses were videotaped and scored later by offline data analyses. Rats were decapitated at the end of the behavioral experiment and in the relevant brain regions, monoamines were assessed. The results demonstrate that isolation of male rats produces a baseline aggression. Treatments with the psychostimulant plant, Catha edulis or commercial S-(--)-cathinone enhanced significantly: The locomotor activities and the baseline aggression behaviors compared with vehicle treated rats. Neurochemical correlates revealed a significant depletion of serotonin (5-HT) and its corresponding metabolites (5-HIAA) in both the anterior and posterior striatum. There was also a reduction in the level of homovanillic acid (HVA) in the hippocampus. Additionally, elevation of dopamine level was observed in the nucleus accumbens, especially, in those rats treated with Catha edulis extract. Cathinone, on the other hand, increased the level of HVA in the posterior striatum and decreased HVA in the nucleus accumbens. In conclusion, the present data demonstrate that repeated administration of Catha edulis or S-(--)-cathinone enhances aggression in rats, presumably by decreasing the level of serotonin and its corresponding metabolites. Besides, the data obtained do not rule out the involvement of dopamine in aggression behavior. SN - 0300-9564 UR - https://www.unboundmedicine.com/medline/citation/16082505/Repeated_Catha_edulis_oral_administration_enhances_the_baseline_aggressive_behavior_in_isolated_rats_ L2 - https://doi.org/10.1007/s00702-005-0356-7 DB - PRIME DP - Unbound Medicine ER -