Tags

Type your tag names separated by a space and hit enter

Impact of fibromyalgia pain on health-related quality of life before and after treatment with tramadol/acetaminophen.

Abstract

OBJECTIVE

To assess health-related quality of life (HRQOL) in patients with moderate-to-severe fibromyalgia pain compared with the general population, and to assess the relationship between pain severity and HRQOL before and after treatment with an analgesic.

METHODS

Data were obtained from a randomized, double-blind study of patients with moderate-to-severe fibromyalgia pain. Patients received either tramadol/acetaminophen or placebo 4 times/day as needed for 91 days. HRQOL was measured with the Short Form 36 Health Survey (SF-36) and the Fibromyalgia Impact Questionnaire (FIQ). Baseline HRQOL scores were compared with a national sample of noninstitutionalized adults and a sample of patients with impaired HRQOL due to congestive heart failure. Patients with fibromyalgia were divided into tertiles by change in pain severity, and SF-36 scores were compared across the tertiles. Mean changes in SF-36 and FIQ scores were compared between treatment groups.

RESULTS

Patients with fibromyalgia scored lower than the US norm on all SF-36 scales (P < 0.0001) and lower than patients with congestive heart failure on most scales. More severe pain was associated with greater impairment of HRQOL compared with less severe pain (P < 0.0001). Patients in the highest tertile for improved pain severity had greater improvement in HRQOL scores than patients in the lower tertiles. Compared with patients who received placebo (n = 157), patients treated with tramadol/acetaminophen (n = 156) showed greater improvement on SF-36 physical functioning, role physical, bodily pain, and physical summary scales, as well as FIQ scales for ability to do job, pain, and stiffness (P < 0.01).

CONCLUSION

Moderate-to-severe fibromyalgia pain significantly impairs HRQOL, and effective pain relief in these patients significantly increases HRQOL.

Links

  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Oregon Health and Science University, Portland, OR 97239, USA. bennetro@ohsu.edu

    , , , ,

    Source

    Arthritis and rheumatism 53:4 2005 Aug 15 pg 519-27

    MeSH

    Acetaminophen
    Adolescent
    Adult
    Aged
    Analgesics, Non-Narcotic
    Analgesics, Opioid
    Double-Blind Method
    Drug Combinations
    Female
    Fibromyalgia
    Heart Failure
    Humans
    Male
    Middle Aged
    Pain
    Quality of Life
    Tramadol

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16082646

    Citation

    Bennett, Robert M., et al. "Impact of Fibromyalgia Pain On Health-related Quality of Life Before and After Treatment With Tramadol/acetaminophen." Arthritis and Rheumatism, vol. 53, no. 4, 2005, pp. 519-27.
    Bennett RM, Schein J, Kosinski MR, et al. Impact of fibromyalgia pain on health-related quality of life before and after treatment with tramadol/acetaminophen. Arthritis Rheum. 2005;53(4):519-27.
    Bennett, R. M., Schein, J., Kosinski, M. R., Hewitt, D. J., Jordan, D. M., & Rosenthal, N. R. (2005). Impact of fibromyalgia pain on health-related quality of life before and after treatment with tramadol/acetaminophen. Arthritis and Rheumatism, 53(4), pp. 519-27.
    Bennett RM, et al. Impact of Fibromyalgia Pain On Health-related Quality of Life Before and After Treatment With Tramadol/acetaminophen. Arthritis Rheum. 2005 Aug 15;53(4):519-27. PubMed PMID: 16082646.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Impact of fibromyalgia pain on health-related quality of life before and after treatment with tramadol/acetaminophen. AU - Bennett,Robert M, AU - Schein,Jeff, AU - Kosinski,Mark R, AU - Hewitt,David J, AU - Jordan,Donna M, AU - Rosenthal,Norman R, PY - 2005/8/6/pubmed PY - 2005/8/27/medline PY - 2005/8/6/entrez SP - 519 EP - 27 JF - Arthritis and rheumatism JO - Arthritis Rheum. VL - 53 IS - 4 N2 - OBJECTIVE: To assess health-related quality of life (HRQOL) in patients with moderate-to-severe fibromyalgia pain compared with the general population, and to assess the relationship between pain severity and HRQOL before and after treatment with an analgesic. METHODS: Data were obtained from a randomized, double-blind study of patients with moderate-to-severe fibromyalgia pain. Patients received either tramadol/acetaminophen or placebo 4 times/day as needed for 91 days. HRQOL was measured with the Short Form 36 Health Survey (SF-36) and the Fibromyalgia Impact Questionnaire (FIQ). Baseline HRQOL scores were compared with a national sample of noninstitutionalized adults and a sample of patients with impaired HRQOL due to congestive heart failure. Patients with fibromyalgia were divided into tertiles by change in pain severity, and SF-36 scores were compared across the tertiles. Mean changes in SF-36 and FIQ scores were compared between treatment groups. RESULTS: Patients with fibromyalgia scored lower than the US norm on all SF-36 scales (P < 0.0001) and lower than patients with congestive heart failure on most scales. More severe pain was associated with greater impairment of HRQOL compared with less severe pain (P < 0.0001). Patients in the highest tertile for improved pain severity had greater improvement in HRQOL scores than patients in the lower tertiles. Compared with patients who received placebo (n = 157), patients treated with tramadol/acetaminophen (n = 156) showed greater improvement on SF-36 physical functioning, role physical, bodily pain, and physical summary scales, as well as FIQ scales for ability to do job, pain, and stiffness (P < 0.01). CONCLUSION: Moderate-to-severe fibromyalgia pain significantly impairs HRQOL, and effective pain relief in these patients significantly increases HRQOL. SN - 0004-3591 UR - https://www.unboundmedicine.com/medline/citation/16082646/Impact_of_fibromyalgia_pain_on_health_related_quality_of_life_before_and_after_treatment_with_tramadol/acetaminophen_ L2 - https://doi.org/10.1002/art.21319 DB - PRIME DP - Unbound Medicine ER -