Tags

Type your tag names separated by a space and hit enter

A more appropriate algorithm of thyroid function test in diagnosis of hyperthyroidism for Thai patients.
J Med Assoc Thai. 2004 Sep; 87 Suppl 2:S19-21.JM

Abstract

BACKGROUND

Thyroid function test is an essential tool in the diagnosis of thyroid dysfunction. To date, it is still controversial which diagnostic algorithm is best applicable to clinically hyperthyroidism patients.

OBJECTIVE

To compare various algorithms of thyroid function tests in the diagnosis of hyperthyroidism.

METHOD

Patients from the endocrine clinic, King Chulalongkorn Memorial Hospital were investigated for thyroid function tests (T3, T4, FT3, FT4 and TSH). Hyperthyroidism was defined as an elevated either FT3 or FT4 with suppressed TSH. The authors compared the effectiveness in hyperthyroidism diagnosis among algorithms by using sensitivity, specificity, positive predictive value and negative predictive value.

RESULTS

Of all 452 patients in the present study, 94.24 percent were women. There were 206 hyperthyroidism, 30 subclinical hyperthyroidism, 1 subclinical hypothyroidism, 8 primary hypothyroidism and 207 normal subjects. The incidence of T3 toxicosis was 16.02% while that of T4 toxicosis was 2.16%. After the effectiveness analysis of these algorithms, FT3 and TSH is the most optimal test with 97.57% sensitivity and 100% specificity. Compared to FT4 and TSH, it gave 83.98% sensitivity and 100% specificity.

CONCLUSION

According to the high incidence of T3 toxicosis in the present study, FT3 and TSH should be the initial test for diagnosis of hyperthyroid patients in an outpatient setting and FT4 should be measured subsequently in case of suspected T4 toxicosis.

Authors+Show Affiliations

Department of Medicine, Faculty of Medicine, Chulalongkorn University, Rama IV Road, Patumwan, Bangkok 10330, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16083155

Citation

Snabboon, Thiti, et al. "A More Appropriate Algorithm of Thyroid Function Test in Diagnosis of Hyperthyroidism for Thai Patients." Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, vol. 87 Suppl 2, 2004, pp. S19-21.
Snabboon T, Sridama V, Sunthornyothin S, et al. A more appropriate algorithm of thyroid function test in diagnosis of hyperthyroidism for Thai patients. J Med Assoc Thai. 2004;87 Suppl 2:S19-21.
Snabboon, T., Sridama, V., Sunthornyothin, S., Suwanwalaikorn, S., & Vongthavaravat, V. (2004). A more appropriate algorithm of thyroid function test in diagnosis of hyperthyroidism for Thai patients. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 87 Suppl 2, S19-21.
Snabboon T, et al. A More Appropriate Algorithm of Thyroid Function Test in Diagnosis of Hyperthyroidism for Thai Patients. J Med Assoc Thai. 2004;87 Suppl 2:S19-21. PubMed PMID: 16083155.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A more appropriate algorithm of thyroid function test in diagnosis of hyperthyroidism for Thai patients. AU - Snabboon,Thiti, AU - Sridama,Vitaya, AU - Sunthornyothin,Sarat, AU - Suwanwalaikorn,Sompongse, AU - Vongthavaravat,Varaphon, PY - 2005/8/9/pubmed PY - 2005/9/8/medline PY - 2005/8/9/entrez SP - S19 EP - 21 JF - Journal of the Medical Association of Thailand = Chotmaihet thangphaet JO - J Med Assoc Thai VL - 87 Suppl 2 N2 - BACKGROUND: Thyroid function test is an essential tool in the diagnosis of thyroid dysfunction. To date, it is still controversial which diagnostic algorithm is best applicable to clinically hyperthyroidism patients. OBJECTIVE: To compare various algorithms of thyroid function tests in the diagnosis of hyperthyroidism. METHOD: Patients from the endocrine clinic, King Chulalongkorn Memorial Hospital were investigated for thyroid function tests (T3, T4, FT3, FT4 and TSH). Hyperthyroidism was defined as an elevated either FT3 or FT4 with suppressed TSH. The authors compared the effectiveness in hyperthyroidism diagnosis among algorithms by using sensitivity, specificity, positive predictive value and negative predictive value. RESULTS: Of all 452 patients in the present study, 94.24 percent were women. There were 206 hyperthyroidism, 30 subclinical hyperthyroidism, 1 subclinical hypothyroidism, 8 primary hypothyroidism and 207 normal subjects. The incidence of T3 toxicosis was 16.02% while that of T4 toxicosis was 2.16%. After the effectiveness analysis of these algorithms, FT3 and TSH is the most optimal test with 97.57% sensitivity and 100% specificity. Compared to FT4 and TSH, it gave 83.98% sensitivity and 100% specificity. CONCLUSION: According to the high incidence of T3 toxicosis in the present study, FT3 and TSH should be the initial test for diagnosis of hyperthyroid patients in an outpatient setting and FT4 should be measured subsequently in case of suspected T4 toxicosis. SN - 0125-2208 UR - https://www.unboundmedicine.com/medline/citation/16083155/A_more_appropriate_algorithm_of_thyroid_function_test_in_diagnosis_of_hyperthyroidism_for_Thai_patients_ L2 - https://medlineplus.gov/hyperthyroidism.html DB - PRIME DP - Unbound Medicine ER -