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A 2-year follow-up study of alcohol consumption and risk of dementia.
Clin Neurol Neurosurg. 2006 Jun; 108(4):378-83.CN

Abstract

BACKGROUND

This report focused on investigating the relationship between alcohol consumption and dementia in elderly people through prospective studies.

METHODS

We conducted a 2-year follow-up study of elderly people from six communities in Chongqing, China. Dementia was detected using the Mini-Mental State Examination (MMSE) and the Diagnostic and Statistical Manual of Mental Disorders (DSM-III-R). The relationship between alcohol consumption and dementia was investigated using multiple logistic regression models, adjusting for the potential confounders age, sex, educational level and cigarette smoking.

RESULTS

Light-to-moderate drinking was associated with a significantly lower risk of dementia compared with non-drinking. Excessive drinking was related to a higher risk of dementia. The effect of light-to-moderate drinking seemed most prominent among vascular dementia, 0.63 (0.55-0.72) for Alzheimer's disease, 0.31 (0.19-0.51) for vascular dementia and 0.45 (0.12-1.69) for other dementia. In a model adjusting for confounding variables, a light-to-moderate intake of beer was associated with a significantly higher risk of dementia than a non-drinker of beer. For wine, a significantly lower risk of dementia existed for a light-to-moderate drinker.

CONCLUSIONS

Light-to-moderate drinking was associated with a significantly lower risk of dementia compared with a non-drinker.

Authors+Show Affiliations

Deng J
2nd Department of Neurology, Research Institute of Surgery and Daping Hospital, Third Military Medical University, Chongqing 400042, China.
Zhou DH
No affiliation info available
Li J
No affiliation info available
Wang YJ
No affiliation info available
Gao C
No affiliation info available
Chen M
No affiliation info available

MeSH

AgedAlcohol DrinkingChinaDementiaFemaleFollow-Up StudiesHumansMaleMiddle AgedNeuropsychological TestsPrevalenceRisk FactorsSeverity of Illness Index

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16084641

Citation

Deng, Juan, et al. "A 2-year Follow-up Study of Alcohol Consumption and Risk of Dementia." Clinical Neurology and Neurosurgery, vol. 108, no. 4, 2006, pp. 378-83.
Deng J, Zhou DH, Li J, et al. A 2-year follow-up study of alcohol consumption and risk of dementia. Clin Neurol Neurosurg. 2006;108(4):378-83.
Deng, J., Zhou, D. H., Li, J., Wang, Y. J., Gao, C., & Chen, M. (2006). A 2-year follow-up study of alcohol consumption and risk of dementia. Clinical Neurology and Neurosurgery, 108(4), 378-83.
Deng J, et al. A 2-year Follow-up Study of Alcohol Consumption and Risk of Dementia. Clin Neurol Neurosurg. 2006;108(4):378-83. PubMed PMID: 16084641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A 2-year follow-up study of alcohol consumption and risk of dementia. AU - Deng,Juan, AU - Zhou,David H D, AU - Li,Jingcheng, AU - Wang,Y John, AU - Gao,Changyue, AU - Chen,Man'e, Y1 - 2005/08/09/ PY - 2004/08/10/received PY - 2005/06/13/revised PY - 2005/06/13/accepted PY - 2005/8/9/pubmed PY - 2006/8/12/medline PY - 2005/8/9/entrez SP - 378 EP - 83 JF - Clinical neurology and neurosurgery JO - Clin Neurol Neurosurg VL - 108 IS - 4 N2 - BACKGROUND: This report focused on investigating the relationship between alcohol consumption and dementia in elderly people through prospective studies. METHODS: We conducted a 2-year follow-up study of elderly people from six communities in Chongqing, China. Dementia was detected using the Mini-Mental State Examination (MMSE) and the Diagnostic and Statistical Manual of Mental Disorders (DSM-III-R). The relationship between alcohol consumption and dementia was investigated using multiple logistic regression models, adjusting for the potential confounders age, sex, educational level and cigarette smoking. RESULTS: Light-to-moderate drinking was associated with a significantly lower risk of dementia compared with non-drinking. Excessive drinking was related to a higher risk of dementia. The effect of light-to-moderate drinking seemed most prominent among vascular dementia, 0.63 (0.55-0.72) for Alzheimer's disease, 0.31 (0.19-0.51) for vascular dementia and 0.45 (0.12-1.69) for other dementia. In a model adjusting for confounding variables, a light-to-moderate intake of beer was associated with a significantly higher risk of dementia than a non-drinker of beer. For wine, a significantly lower risk of dementia existed for a light-to-moderate drinker. CONCLUSIONS: Light-to-moderate drinking was associated with a significantly lower risk of dementia compared with a non-drinker. SN - 0303-8467 UR - https://www.unboundmedicine.com/medline/citation/16084641/A_2_year_follow_up_study_of_alcohol_consumption_and_risk_of_dementia_ DB - PRIME DP - Unbound Medicine ER -