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Possible role of superoxide dismutases in the yeast Saccharomyces cerevisiae under respiratory conditions.
Arch Biochem Biophys. 2005 Sep 01; 441(1):35-40.AB

Abstract

We have analyzed the activity of antioxidant and tricarboxylic acid cycle enzymes as well as protein carbonyl content in budding yeast Saccharomyces cerevisiae cells grown in medium with glycerol using wild-strain cells and defective mutants in superoxide dismutases (SODs). The present report demonstrates that the activity of catalase, glucose-6-phosphate dehydrogenase, glutathione reductase, isocitrate dehydrogenase, succinate dehydrogenase, and malate dehydrogenase, on average, was lower in the strains lacking SODs than that in the parental strain. On the other hand, under conditions used in this study, the content of carbonyl groups in proteins was relatively higher in the wild type as compared with SOD-defective strains. It may be suggested that in vivo SOD can demonstrate protective as well as pro-oxidant properties, and the final result depends on particular conditions.

Authors+Show Affiliations

Department of Biochemistry, Vassyl Stefanyk Precarpathian National University, 57 Shevchenko Str., Ivano-Frankivsk 76025, Ukraine.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16084798

Citation

Lushchak, Volodymyr, et al. "Possible Role of Superoxide Dismutases in the Yeast Saccharomyces Cerevisiae Under Respiratory Conditions." Archives of Biochemistry and Biophysics, vol. 441, no. 1, 2005, pp. 35-40.
Lushchak V, Semchyshyn H, Mandryk S, et al. Possible role of superoxide dismutases in the yeast Saccharomyces cerevisiae under respiratory conditions. Arch Biochem Biophys. 2005;441(1):35-40.
Lushchak, V., Semchyshyn, H., Mandryk, S., & Lushchak, O. (2005). Possible role of superoxide dismutases in the yeast Saccharomyces cerevisiae under respiratory conditions. Archives of Biochemistry and Biophysics, 441(1), 35-40.
Lushchak V, et al. Possible Role of Superoxide Dismutases in the Yeast Saccharomyces Cerevisiae Under Respiratory Conditions. Arch Biochem Biophys. 2005 Sep 1;441(1):35-40. PubMed PMID: 16084798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible role of superoxide dismutases in the yeast Saccharomyces cerevisiae under respiratory conditions. AU - Lushchak,Volodymyr, AU - Semchyshyn,Halyna, AU - Mandryk,Serhij, AU - Lushchak,Oleh, PY - 2005/06/10/received PY - 2005/06/18/revised PY - 2005/06/20/accepted PY - 2005/8/9/pubmed PY - 2005/10/29/medline PY - 2005/8/9/entrez SP - 35 EP - 40 JF - Archives of biochemistry and biophysics JO - Arch Biochem Biophys VL - 441 IS - 1 N2 - We have analyzed the activity of antioxidant and tricarboxylic acid cycle enzymes as well as protein carbonyl content in budding yeast Saccharomyces cerevisiae cells grown in medium with glycerol using wild-strain cells and defective mutants in superoxide dismutases (SODs). The present report demonstrates that the activity of catalase, glucose-6-phosphate dehydrogenase, glutathione reductase, isocitrate dehydrogenase, succinate dehydrogenase, and malate dehydrogenase, on average, was lower in the strains lacking SODs than that in the parental strain. On the other hand, under conditions used in this study, the content of carbonyl groups in proteins was relatively higher in the wild type as compared with SOD-defective strains. It may be suggested that in vivo SOD can demonstrate protective as well as pro-oxidant properties, and the final result depends on particular conditions. SN - 0003-9861 UR - https://www.unboundmedicine.com/medline/citation/16084798/Possible_role_of_superoxide_dismutases_in_the_yeast_Saccharomyces_cerevisiae_under_respiratory_conditions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-9861(05)00257-2 DB - PRIME DP - Unbound Medicine ER -