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Prenatal anxiety predicts individual differences in cortisol in pre-adolescent children.
Biol Psychiatry. 2005 Aug 01; 58(3):211-7.BP

Abstract

BACKGROUND

Animal studies suggest that prenatal stress is associated with long-term disturbance in hypothalamic-pituitary-adrenal (HPA) axis function, but evidence in humans is lacking. This study examined the long-term association between prenatal anxiety and measures of diurnal cortisol at age 10 years.

METHODS

Measures of cortisol were collected at awakening, 30 min after awakening, and at 4 pm and 9 pm on 3 consecutive days in a sample of 10-year-olds (n = 74) from the Avon Longitudinal Study of Parents and Children, a prospective longitudinal cohort study of mothers and children on whom measures of anxiety and depression were collected in pregnancy and the postpartum period. Analyses examined the links between symptoms of prenatal anxiety and multiple indicators of cortisol, an index of HPA axis functioning.

RESULTS

Prenatal anxiety was significantly associated with individual differences in awakening and afternoon cortisol after accounting for obstetric and sociodemographic risk (partial correlations were .32 and .25, p < .05). The effect for awakening cortisol remained significant after controlling for multiple postnatal assessments of maternal anxiety and depression.

CONCLUSIONS

This study provides the first human evidence that prenatal anxiety might have lasting effects on HPA axis functioning in the child and that prenatal anxiety might constitute a mechanism for an increased vulnerability to psychopathology in children and adolescents.

Authors+Show Affiliations

Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Boulevard, Rochester, NY 14642, USA. Tom_OConnor@URMC.Rochester.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16084841

Citation

O'Connor, Thomas G., et al. "Prenatal Anxiety Predicts Individual Differences in Cortisol in Pre-adolescent Children." Biological Psychiatry, vol. 58, no. 3, 2005, pp. 211-7.
O'Connor TG, Ben-Shlomo Y, Heron J, et al. Prenatal anxiety predicts individual differences in cortisol in pre-adolescent children. Biol Psychiatry. 2005;58(3):211-7.
O'Connor, T. G., Ben-Shlomo, Y., Heron, J., Golding, J., Adams, D., & Glover, V. (2005). Prenatal anxiety predicts individual differences in cortisol in pre-adolescent children. Biological Psychiatry, 58(3), 211-7.
O'Connor TG, et al. Prenatal Anxiety Predicts Individual Differences in Cortisol in Pre-adolescent Children. Biol Psychiatry. 2005 Aug 1;58(3):211-7. PubMed PMID: 16084841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal anxiety predicts individual differences in cortisol in pre-adolescent children. AU - O'Connor,Thomas G, AU - Ben-Shlomo,Yoav, AU - Heron,Jon, AU - Golding,Jean, AU - Adams,Diana, AU - Glover,Vivette, PY - 2004/08/27/received PY - 2005/01/10/revised PY - 2005/03/17/accepted PY - 2005/8/9/pubmed PY - 2005/9/20/medline PY - 2005/8/9/entrez SP - 211 EP - 7 JF - Biological psychiatry JO - Biol Psychiatry VL - 58 IS - 3 N2 - BACKGROUND: Animal studies suggest that prenatal stress is associated with long-term disturbance in hypothalamic-pituitary-adrenal (HPA) axis function, but evidence in humans is lacking. This study examined the long-term association between prenatal anxiety and measures of diurnal cortisol at age 10 years. METHODS: Measures of cortisol were collected at awakening, 30 min after awakening, and at 4 pm and 9 pm on 3 consecutive days in a sample of 10-year-olds (n = 74) from the Avon Longitudinal Study of Parents and Children, a prospective longitudinal cohort study of mothers and children on whom measures of anxiety and depression were collected in pregnancy and the postpartum period. Analyses examined the links between symptoms of prenatal anxiety and multiple indicators of cortisol, an index of HPA axis functioning. RESULTS: Prenatal anxiety was significantly associated with individual differences in awakening and afternoon cortisol after accounting for obstetric and sociodemographic risk (partial correlations were .32 and .25, p < .05). The effect for awakening cortisol remained significant after controlling for multiple postnatal assessments of maternal anxiety and depression. CONCLUSIONS: This study provides the first human evidence that prenatal anxiety might have lasting effects on HPA axis functioning in the child and that prenatal anxiety might constitute a mechanism for an increased vulnerability to psychopathology in children and adolescents. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/16084841/Prenatal_anxiety_predicts_individual_differences_in_cortisol_in_pre_adolescent_children_ DB - PRIME DP - Unbound Medicine ER -