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Effect of different preparations of hormone therapy on lipid and glucose metabolism, coagulation factors, and bone mineral density in overweight and obese postmenopausal women.
Fertil Steril. 2005 Aug; 84(2):384-93.FS

Abstract

OBJECTIVE

To determine the effects of different preparations of hormone therapy (HT) on lipid and glucose metabolism, coagulation factors, and bone mineral density (BMD) in overweight and obese postmenopausal women.

DESIGN

A randomized, nonblinded, controlled study.

SETTING

Karadeniz Technical University, Department of Obstetrics and Gynecology.

PATIENT(S)

A total of 352 overweight and obese (body mass index >25 kg/m2) postmenopausal women.

INTERVENTION(S)

Ninety women received 2.5 mg of tibolone; 84 received 2 mg of E2 plus 1 mg of norethisterone acetate (E2/NETA); 90 received 0.625 mg of conjugated equine estrogen plus 2.5 mg of medroxyprogesterone acetate (CEE/MPA); and 88 did not receive any menopausal therapy (control).

MAIN OUTCOME MEASURE(S)

At baseline and after 6 months of treatment, we measured total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), insulin, glucose, factor VII, factor VIII, von Willebrand factor, antithrombin III, protein S, protein C, fibrinogen, and BMD at the lumbar spine L1-L4.

RESULT(S)

There were no statistically significant differences among the groups for any variables at baseline. After 6 months of treatment, the three regimens decreased total cholesterol, triglyceride, LDL, and fibrinogen; E2/NETA and CEE/MPA increased HDL, and tibolone decreased HDL; higher insulin concentrations were found in the control and tibolone groups. Body mass index, HDL, fibrinogen levels, and L1-L4 BMD were independent factors in the prediction of HT use.

CONCLUSION(S)

Body mass index, HDL, fibrinogen levels and L1-L4 BMD were independent factors in the prediction of HT use. Treatment with tibolone, E2/NETA, and CEE/MPA resulted in minimal improvement in lumbar spine BMD but had a beneficial effect on the procoagulation system, with minimal changes in glucose metabolism after 6 months of therapy.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Karadeniz Technical University, Trabzon, Turkey. osmanaga@meds.ktu.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16084879

Citation

Osmanağaoğlu, Mehmet A., et al. "Effect of Different Preparations of Hormone Therapy On Lipid and Glucose Metabolism, Coagulation Factors, and Bone Mineral Density in Overweight and Obese Postmenopausal Women." Fertility and Sterility, vol. 84, no. 2, 2005, pp. 384-93.
Osmanağaoğlu MA, Osmanağaoğlu S, Osmanağaoğlu T, et al. Effect of different preparations of hormone therapy on lipid and glucose metabolism, coagulation factors, and bone mineral density in overweight and obese postmenopausal women. Fertil Steril. 2005;84(2):384-93.
Osmanağaoğlu, M. A., Osmanağaoğlu, S., Osmanağaoğlu, T., Okumuş, B., & Bozkaya, H. (2005). Effect of different preparations of hormone therapy on lipid and glucose metabolism, coagulation factors, and bone mineral density in overweight and obese postmenopausal women. Fertility and Sterility, 84(2), 384-93.
Osmanağaoğlu MA, et al. Effect of Different Preparations of Hormone Therapy On Lipid and Glucose Metabolism, Coagulation Factors, and Bone Mineral Density in Overweight and Obese Postmenopausal Women. Fertil Steril. 2005;84(2):384-93. PubMed PMID: 16084879.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of different preparations of hormone therapy on lipid and glucose metabolism, coagulation factors, and bone mineral density in overweight and obese postmenopausal women. AU - Osmanağaoğlu,Mehmet A, AU - Osmanağaoğlu,Selen, AU - Osmanağaoğlu,Tayfun, AU - Okumuş,Bakiye, AU - Bozkaya,Hasan, PY - 2004/07/23/received PY - 2005/01/27/revised PY - 2005/01/27/accepted PY - 2005/8/9/pubmed PY - 2005/12/28/medline PY - 2005/8/9/entrez SP - 384 EP - 93 JF - Fertility and sterility JO - Fertil Steril VL - 84 IS - 2 N2 - OBJECTIVE: To determine the effects of different preparations of hormone therapy (HT) on lipid and glucose metabolism, coagulation factors, and bone mineral density (BMD) in overweight and obese postmenopausal women. DESIGN: A randomized, nonblinded, controlled study. SETTING: Karadeniz Technical University, Department of Obstetrics and Gynecology. PATIENT(S): A total of 352 overweight and obese (body mass index >25 kg/m2) postmenopausal women. INTERVENTION(S): Ninety women received 2.5 mg of tibolone; 84 received 2 mg of E2 plus 1 mg of norethisterone acetate (E2/NETA); 90 received 0.625 mg of conjugated equine estrogen plus 2.5 mg of medroxyprogesterone acetate (CEE/MPA); and 88 did not receive any menopausal therapy (control). MAIN OUTCOME MEASURE(S): At baseline and after 6 months of treatment, we measured total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), insulin, glucose, factor VII, factor VIII, von Willebrand factor, antithrombin III, protein S, protein C, fibrinogen, and BMD at the lumbar spine L1-L4. RESULT(S): There were no statistically significant differences among the groups for any variables at baseline. After 6 months of treatment, the three regimens decreased total cholesterol, triglyceride, LDL, and fibrinogen; E2/NETA and CEE/MPA increased HDL, and tibolone decreased HDL; higher insulin concentrations were found in the control and tibolone groups. Body mass index, HDL, fibrinogen levels, and L1-L4 BMD were independent factors in the prediction of HT use. CONCLUSION(S): Body mass index, HDL, fibrinogen levels and L1-L4 BMD were independent factors in the prediction of HT use. Treatment with tibolone, E2/NETA, and CEE/MPA resulted in minimal improvement in lumbar spine BMD but had a beneficial effect on the procoagulation system, with minimal changes in glucose metabolism after 6 months of therapy. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/16084879/Effect_of_different_preparations_of_hormone_therapy_on_lipid_and_glucose_metabolism_coagulation_factors_and_bone_mineral_density_in_overweight_and_obese_postmenopausal_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(05)00851-4 DB - PRIME DP - Unbound Medicine ER -