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Plasma triglycerides, an independent predictor of cardiovascular disease in men: a prospective study based on a population with prevalent metabolic syndrome.
Int J Cardiol. 2006 Mar 22; 108(1):89-95.IJ

Abstract

BACKGROUND AND METHODS

We aimed to assess whether fasting plasma triglycerides independently predicted future fatal and nonfatal cardiovascular disease (CVD) in a population having a high prevalence of the metabolic syndrome. In the Turkish Adult Risk Factor Study, a population-based survey, 2682 men and women 20 years of age or over with fasting triglyceride values available and free of CVD at baseline examination in 1990, were prospectively followed up till 2003/04. Triglyceride concentrations were measured by the enzymatic dry chemistry method and stratified into sex-specific quintiles. Information on the mode of death was obtained from first-degree relatives and/or health personnel of local health office. Diagnosis of coronary heart disease and stroke among survivors was based on history, physical examination of the cardiovascular system and Minnesota coding of resting electrocardiograms. A total of 120 fatal and 221 new nonfatal CVD occurred among adults (mean age 43+/-14) during a mean 9.3 years of follow-up.

RESULTS

CVD was significantly and independently predicted by the top versus the bottom fasting triglyceride quintile in logistic regression analyses when adjusted for age, sex, BMI, systolic blood pressure, total cholesterol, lipid-lowering medication, status of smoking and of glucose regulation (relative risk [RR] in men and all adults 2.38 and 1.79, respectively, p both <0.02). This corresponded to hazard ratios (HR) of 1.43 in men and 1.28 in men and women combined. Adjustment for HDL-cholesterol instead of total cholesterol in the same model gave also significant HRs corresponding to 1.42 in men and 1.32 in sexes combined.

CONCLUSIONS

Fasting triglycerides are predictive of future CVD among men with an HR of 1.4, independent of age, diabetes, lipid-lowering medication, traditional risk factors including total cholesterol or HDL-C, in a population in which metabolic syndrome prevails. A modest independent risk increment in women did not reach significance.

Authors+Show Affiliations

Turkish Society of Cardiology, Istanbul, Turkey. tkd@tkd.org.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16085325

Citation

Onat, Altan, et al. "Plasma Triglycerides, an Independent Predictor of Cardiovascular Disease in Men: a Prospective Study Based On a Population With Prevalent Metabolic Syndrome." International Journal of Cardiology, vol. 108, no. 1, 2006, pp. 89-95.
Onat A, Sari I, Yazici M, et al. Plasma triglycerides, an independent predictor of cardiovascular disease in men: a prospective study based on a population with prevalent metabolic syndrome. Int J Cardiol. 2006;108(1):89-95.
Onat, A., Sari, I., Yazici, M., Can, G., Hergenç, G., & Avci, G. S. (2006). Plasma triglycerides, an independent predictor of cardiovascular disease in men: a prospective study based on a population with prevalent metabolic syndrome. International Journal of Cardiology, 108(1), 89-95.
Onat A, et al. Plasma Triglycerides, an Independent Predictor of Cardiovascular Disease in Men: a Prospective Study Based On a Population With Prevalent Metabolic Syndrome. Int J Cardiol. 2006 Mar 22;108(1):89-95. PubMed PMID: 16085325.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma triglycerides, an independent predictor of cardiovascular disease in men: a prospective study based on a population with prevalent metabolic syndrome. AU - Onat,Altan, AU - Sari,Ibrahim, AU - Yazici,Mehmet, AU - Can,Günay, AU - Hergenç,Gülay, AU - Avci,Günsel S, Y1 - 2005/08/08/ PY - 2005/04/29/received PY - 2005/06/22/revised PY - 2005/06/26/accepted PY - 2005/8/9/pubmed PY - 2006/8/11/medline PY - 2005/8/9/entrez SP - 89 EP - 95 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 108 IS - 1 N2 - BACKGROUND AND METHODS: We aimed to assess whether fasting plasma triglycerides independently predicted future fatal and nonfatal cardiovascular disease (CVD) in a population having a high prevalence of the metabolic syndrome. In the Turkish Adult Risk Factor Study, a population-based survey, 2682 men and women 20 years of age or over with fasting triglyceride values available and free of CVD at baseline examination in 1990, were prospectively followed up till 2003/04. Triglyceride concentrations were measured by the enzymatic dry chemistry method and stratified into sex-specific quintiles. Information on the mode of death was obtained from first-degree relatives and/or health personnel of local health office. Diagnosis of coronary heart disease and stroke among survivors was based on history, physical examination of the cardiovascular system and Minnesota coding of resting electrocardiograms. A total of 120 fatal and 221 new nonfatal CVD occurred among adults (mean age 43+/-14) during a mean 9.3 years of follow-up. RESULTS: CVD was significantly and independently predicted by the top versus the bottom fasting triglyceride quintile in logistic regression analyses when adjusted for age, sex, BMI, systolic blood pressure, total cholesterol, lipid-lowering medication, status of smoking and of glucose regulation (relative risk [RR] in men and all adults 2.38 and 1.79, respectively, p both <0.02). This corresponded to hazard ratios (HR) of 1.43 in men and 1.28 in men and women combined. Adjustment for HDL-cholesterol instead of total cholesterol in the same model gave also significant HRs corresponding to 1.42 in men and 1.32 in sexes combined. CONCLUSIONS: Fasting triglycerides are predictive of future CVD among men with an HR of 1.4, independent of age, diabetes, lipid-lowering medication, traditional risk factors including total cholesterol or HDL-C, in a population in which metabolic syndrome prevails. A modest independent risk increment in women did not reach significance. SN - 0167-5273 UR - https://www.unboundmedicine.com/medline/citation/16085325/Plasma_triglycerides_an_independent_predictor_of_cardiovascular_disease_in_men:_a_prospective_study_based_on_a_population_with_prevalent_metabolic_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(05)00899-5 DB - PRIME DP - Unbound Medicine ER -