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[Association of Xba I, Pvu II, and Bst U I polymorphisms of estrogen receptor-alpha gene with bone mass in men].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005 Aug; 22(4):447-9.ZY

Abstract

OBJECTIVE

To investigate the association of polymorphism in estrogen receptor-alpha (ER-alpha) gene with bone mineral density(BMD) in men.

METHODS

The ER-alpha Xba I, Pvu II and Bst UI genotypes were determined by PCR-restriction fragment length polymorphism (RFLP) in 388 unrelated healthy men who were 46-80 years old and were of Han nationalities in Shanghai city. Bone mineral densities (BMD, g/cm(2)) at lumbar spines 1-4 (L(1-4)) and at any sites of proximal femur, including femoral neck (Neck), trochanter (Troch) and Ward's triangle (Ward's) were measured by duel-energy X-ray absorptiometry.

RESULTS

The frequencies distribution of Xba I and Pvu II alleles and genotypes in this cohort all followed the Hardy-Weinberg equilibrium. No Bst UI polymorphic site in ER-alpha gene was found in total samples. All subjects were of BB genotype. No significant association was found between Xba I genotype and BMD at any skeleton sites. The significant association was found between Pvu II genotype and BMD at L(1-4) and Ward's triangle site (P< 0.05). Compared against men with PP and pp genotype, men with Pp genotype had significantly higher mean BMD at L(1-4) and Ward's triangle site (P< 0.05).

CONCLUSION

This study suggests that Bst UI polymorphism in ER-alpha gene may be absent or rare in Chinese Han population. Pvu II polymorphism possibly influences the loss of trabecular bone mass in old men.

Authors+Show Affiliations

Center for Preventing and Treating Osteoporosis, Osteoporosis Research Unit, Affiliated Sixth People Hospital, Shanghai Jiaotong University, Shanghai, 200233 PR China. ZZL2002@medmail.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

16086289

Citation

Zhang, Zhen-lin, et al. "[Association of Xba I, Pvu II, and Bst U I Polymorphisms of Estrogen Receptor-alpha Gene With Bone Mass in Men]." Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, vol. 22, no. 4, 2005, pp. 447-9.
Zhang ZL, Qin YJ, He JW, et al. [Association of Xba I, Pvu II, and Bst U I polymorphisms of estrogen receptor-alpha gene with bone mass in men]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005;22(4):447-9.
Zhang, Z. L., Qin, Y. J., He, J. W., Huang, Q. R., Hu, Y. Q., Li, M., Liu, Y. J., & Zhang, H. (2005). [Association of Xba I, Pvu II, and Bst U I polymorphisms of estrogen receptor-alpha gene with bone mass in men]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, 22(4), 447-9.
Zhang ZL, et al. [Association of Xba I, Pvu II, and Bst U I Polymorphisms of Estrogen Receptor-alpha Gene With Bone Mass in Men]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005;22(4):447-9. PubMed PMID: 16086289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Association of Xba I, Pvu II, and Bst U I polymorphisms of estrogen receptor-alpha gene with bone mass in men]. AU - Zhang,Zhen-lin, AU - Qin,Yue-juan, AU - He,Jin-wei, AU - Huang,Qi-ren, AU - Hu,Yun-qiu, AU - Li,Miao, AU - Liu,Yu-juan, AU - Zhang,Hao, PY - 2005/8/9/pubmed PY - 2009/3/20/medline PY - 2005/8/9/entrez SP - 447 EP - 9 JF - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics JO - Zhonghua Yi Xue Yi Chuan Xue Za Zhi VL - 22 IS - 4 N2 - OBJECTIVE: To investigate the association of polymorphism in estrogen receptor-alpha (ER-alpha) gene with bone mineral density(BMD) in men. METHODS: The ER-alpha Xba I, Pvu II and Bst UI genotypes were determined by PCR-restriction fragment length polymorphism (RFLP) in 388 unrelated healthy men who were 46-80 years old and were of Han nationalities in Shanghai city. Bone mineral densities (BMD, g/cm(2)) at lumbar spines 1-4 (L(1-4)) and at any sites of proximal femur, including femoral neck (Neck), trochanter (Troch) and Ward's triangle (Ward's) were measured by duel-energy X-ray absorptiometry. RESULTS: The frequencies distribution of Xba I and Pvu II alleles and genotypes in this cohort all followed the Hardy-Weinberg equilibrium. No Bst UI polymorphic site in ER-alpha gene was found in total samples. All subjects were of BB genotype. No significant association was found between Xba I genotype and BMD at any skeleton sites. The significant association was found between Pvu II genotype and BMD at L(1-4) and Ward's triangle site (P< 0.05). Compared against men with PP and pp genotype, men with Pp genotype had significantly higher mean BMD at L(1-4) and Ward's triangle site (P< 0.05). CONCLUSION: This study suggests that Bst UI polymorphism in ER-alpha gene may be absent or rare in Chinese Han population. Pvu II polymorphism possibly influences the loss of trabecular bone mass in old men. SN - 1003-9406 UR - https://www.unboundmedicine.com/medline/citation/16086289/[Association_of_Xba_I_Pvu_II_and_Bst_U_I_polymorphisms_of_estrogen_receptor_alpha_gene_with_bone_mass_in_men]_ L2 - https://medlineplus.gov/bonedensity.html DB - PRIME DP - Unbound Medicine ER -