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Epilepsy and intrathecal baclofen therapy in children with cerebral palsy.
Pediatr Neurol. 2005 Aug; 33(2):110-3.PN

Abstract

The objective of this study was to analyze the relationship between epilepsy and intrathecal baclofen by investigating a consecutive sample of 150 children with cerebral palsy or spasticity of cerebral origin who underwent intrathecal baclofen. The medical charts of the 150 children were retrospectively reviewed. A series of 100 children with cerebral palsy, operated on other procedures, was reviewed as a control group. Forty percent of the 150 children had epilepsy before intrathecal baclofen pump implantation; 13.3% had a decrease in seizure frequency after intrathecal baclofen, while two children worsened and one child had seizures ex novo. We conclude that in children with spasticity of cerebral origin, intrathecal baclofen does not seem to aggravate or induce seizure activity.

Authors+Show Affiliations

Department of Paediatric Orthopedics, Children's Hospital V. Buzzi, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16087055

Citation

Buonaguro, Vincenzo, et al. "Epilepsy and Intrathecal Baclofen Therapy in Children With Cerebral Palsy." Pediatric Neurology, vol. 33, no. 2, 2005, pp. 110-3.
Buonaguro V, Scelsa B, Curci D, et al. Epilepsy and intrathecal baclofen therapy in children with cerebral palsy. Pediatr Neurol. 2005;33(2):110-3.
Buonaguro, V., Scelsa, B., Curci, D., Monforte, S., Iuorno, T., & Motta, F. (2005). Epilepsy and intrathecal baclofen therapy in children with cerebral palsy. Pediatric Neurology, 33(2), 110-3.
Buonaguro V, et al. Epilepsy and Intrathecal Baclofen Therapy in Children With Cerebral Palsy. Pediatr Neurol. 2005;33(2):110-3. PubMed PMID: 16087055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epilepsy and intrathecal baclofen therapy in children with cerebral palsy. AU - Buonaguro,Vincenzo, AU - Scelsa,Barbara, AU - Curci,Domenico, AU - Monforte,Sergio, AU - Iuorno,Teresa, AU - Motta,Francesco, PY - 2004/11/17/received PY - 2004/12/06/revised PY - 2005/03/07/accepted PY - 2005/8/10/pubmed PY - 2005/10/21/medline PY - 2005/8/10/entrez SP - 110 EP - 3 JF - Pediatric neurology JO - Pediatr. Neurol. VL - 33 IS - 2 N2 - The objective of this study was to analyze the relationship between epilepsy and intrathecal baclofen by investigating a consecutive sample of 150 children with cerebral palsy or spasticity of cerebral origin who underwent intrathecal baclofen. The medical charts of the 150 children were retrospectively reviewed. A series of 100 children with cerebral palsy, operated on other procedures, was reviewed as a control group. Forty percent of the 150 children had epilepsy before intrathecal baclofen pump implantation; 13.3% had a decrease in seizure frequency after intrathecal baclofen, while two children worsened and one child had seizures ex novo. We conclude that in children with spasticity of cerebral origin, intrathecal baclofen does not seem to aggravate or induce seizure activity. SN - 0887-8994 UR - https://www.unboundmedicine.com/medline/citation/16087055/Epilepsy_and_intrathecal_baclofen_therapy_in_children_with_cerebral_palsy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0887-8994(05)00164-5 DB - PRIME DP - Unbound Medicine ER -