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Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes.
Biochem Biophys Res Commun. 2005 Sep 23; 335(2):596-602.BB

Abstract

Resistin, secreted from adipocytes, causes insulin resistance in rodents. Its roles and main source in humans remain unknown. The G/G genotype of resistin single nucleotide polymorphism, SNP-420, induces type 2 diabetes mellitus (T2DM) by increasing promoter activity. We elucidated factors correlated with serum resistin and effects of SNP-420 on monocyte resistin mRNA. In 198 T2DM and 157 controls, fasting serum resistin was higher in T2DM. Multiple regression analysis revealed that SNP-420 genotype was the strongest determinant of serum resistin. In T2DM, 1-year duration of T2DM and 1% HbA1c was also correlated with 0.19 and 0.54 ng/ml serum resistin, respectively. Logistic regression analysis revealed that serum resistin was an independent factor for T2DM. In 23 healthy volunteers, monocyte resistin mRNA was positively correlated with its simultaneous serum levels and was higher in G/G genotype. Thus, SNP-420 determines monocyte mRNA and serum levels of resistin, which could induce T2DM.

Authors+Show Affiliations

Department of Laboratory Medicine, Ehime University School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan. harosawa@m.ehime-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16087164

Citation

Osawa, Haruhiko, et al. "Resistin SNP-420 Determines Its Monocyte mRNA and Serum Levels Inducing Type 2 Diabetes." Biochemical and Biophysical Research Communications, vol. 335, no. 2, 2005, pp. 596-602.
Osawa H, Onuma H, Ochi M, et al. Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes. Biochem Biophys Res Commun. 2005;335(2):596-602.
Osawa, H., Onuma, H., Ochi, M., Murakami, A., Yamauchi, J., Takasuka, T., Tanabe, F., Shimizu, I., Kato, K., Nishida, W., Yamada, K., Tabara, Y., Yasukawa, M., Fujii, Y., Ohashi, J., Miki, T., & Makino, H. (2005). Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes. Biochemical and Biophysical Research Communications, 335(2), 596-602.
Osawa H, et al. Resistin SNP-420 Determines Its Monocyte mRNA and Serum Levels Inducing Type 2 Diabetes. Biochem Biophys Res Commun. 2005 Sep 23;335(2):596-602. PubMed PMID: 16087164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes. AU - Osawa,Haruhiko, AU - Onuma,Hiroshi, AU - Ochi,Masaaki, AU - Murakami,Akiko, AU - Yamauchi,Junko, AU - Takasuka,Tomomi, AU - Tanabe,Fumiko, AU - Shimizu,Ikki, AU - Kato,Kenichi, AU - Nishida,Wataru, AU - Yamada,Kazuya, AU - Tabara,Yasuharu, AU - Yasukawa,Masaki, AU - Fujii,Yasuhisa, AU - Ohashi,Jun, AU - Miki,Tetsuro, AU - Makino,Hideichi, PY - 2005/07/06/received PY - 2005/07/22/accepted PY - 2005/8/10/pubmed PY - 2005/10/15/medline PY - 2005/8/10/entrez SP - 596 EP - 602 JF - Biochemical and biophysical research communications JO - Biochem. Biophys. Res. Commun. VL - 335 IS - 2 N2 - Resistin, secreted from adipocytes, causes insulin resistance in rodents. Its roles and main source in humans remain unknown. The G/G genotype of resistin single nucleotide polymorphism, SNP-420, induces type 2 diabetes mellitus (T2DM) by increasing promoter activity. We elucidated factors correlated with serum resistin and effects of SNP-420 on monocyte resistin mRNA. In 198 T2DM and 157 controls, fasting serum resistin was higher in T2DM. Multiple regression analysis revealed that SNP-420 genotype was the strongest determinant of serum resistin. In T2DM, 1-year duration of T2DM and 1% HbA1c was also correlated with 0.19 and 0.54 ng/ml serum resistin, respectively. Logistic regression analysis revealed that serum resistin was an independent factor for T2DM. In 23 healthy volunteers, monocyte resistin mRNA was positively correlated with its simultaneous serum levels and was higher in G/G genotype. Thus, SNP-420 determines monocyte mRNA and serum levels of resistin, which could induce T2DM. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/16087164/Resistin_SNP_420_determines_its_monocyte_mRNA_and_serum_levels_inducing_type_2_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(05)01612-8 DB - PRIME DP - Unbound Medicine ER -