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Use of oral nutritional supplements in patients with Huntington's disease.
Nutrition. 2005 Sep; 21(9):889-94.N

Abstract

OBJECTIVE

This study assessed the effect of oral nutritional supplements on the nutritional status of patients with Huntington's disease.

METHODS

This was an experimental, longitudinal, prospective study of 30 patients with Huntington's disease. We performed neurologic evaluation and dietary assessment and measured anthropometric indexes and biochemical indicators; in addition, patients were questioned about their weight, appetite, chewing difficulty, and dysphagia. Patients consumed two cans daily of a nutritional supplement that contributed an extra 473 kcal to their diet for a 90-d period. At the study's end, the supplement was suspended and the same variables were reassessed.

RESULTS

After 90 d, 68.7% of patients had increased body weight, 68.7% had ideal body weight percentages and body mass indexes, 53.3% had increased midarm circumferences, and 60.0% had increased arm muscle circumferences and body fat percentages; these changes were statistically significant (P < 0.05). The neurologic evaluation subscales and the biochemical indicators did not change significantly. With regard to subjective variables, patients who reported losing weight during the 3 mo before the study did not lose more weight and patients who reported having an increased appetite before the study remained stable during the study.

CONCLUSIONS

The nutritional intervention stabilized or slightly improved the anthropometric variables assessed; however, no significant change in body mass index occurred in 87% of patients. For the purpose of maintaining an acceptable nutritional status in patients who have Huntington's disease and normal nutritional status, we suggest oral nutritional supplements that contribute an average of 473 kcal/d in addition to a normal diet.

Authors+Show Affiliations

Nutrition Laboratory, Instituto Nacional de Neurología y Neurocirugía MVS, Mexico DF, Mexico. aratrejoc@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

16087319

Citation

Trejo, Araceli, et al. "Use of Oral Nutritional Supplements in Patients With Huntington's Disease." Nutrition (Burbank, Los Angeles County, Calif.), vol. 21, no. 9, 2005, pp. 889-94.
Trejo A, Boll MC, Alonso ME, et al. Use of oral nutritional supplements in patients with Huntington's disease. Nutrition. 2005;21(9):889-94.
Trejo, A., Boll, M. C., Alonso, M. E., Ochoa, A., & Velásquez, L. (2005). Use of oral nutritional supplements in patients with Huntington's disease. Nutrition (Burbank, Los Angeles County, Calif.), 21(9), 889-94.
Trejo A, et al. Use of Oral Nutritional Supplements in Patients With Huntington's Disease. Nutrition. 2005;21(9):889-94. PubMed PMID: 16087319.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of oral nutritional supplements in patients with Huntington's disease. AU - Trejo,Araceli, AU - Boll,Marie-Catherine, AU - Alonso,Ma Elisa, AU - Ochoa,Adriana, AU - Velásquez,Leora, PY - 2004/05/11/received PY - 2004/12/01/accepted PY - 2005/8/10/pubmed PY - 2006/1/27/medline PY - 2005/8/10/entrez SP - 889 EP - 94 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 21 IS - 9 N2 - OBJECTIVE: This study assessed the effect of oral nutritional supplements on the nutritional status of patients with Huntington's disease. METHODS: This was an experimental, longitudinal, prospective study of 30 patients with Huntington's disease. We performed neurologic evaluation and dietary assessment and measured anthropometric indexes and biochemical indicators; in addition, patients were questioned about their weight, appetite, chewing difficulty, and dysphagia. Patients consumed two cans daily of a nutritional supplement that contributed an extra 473 kcal to their diet for a 90-d period. At the study's end, the supplement was suspended and the same variables were reassessed. RESULTS: After 90 d, 68.7% of patients had increased body weight, 68.7% had ideal body weight percentages and body mass indexes, 53.3% had increased midarm circumferences, and 60.0% had increased arm muscle circumferences and body fat percentages; these changes were statistically significant (P < 0.05). The neurologic evaluation subscales and the biochemical indicators did not change significantly. With regard to subjective variables, patients who reported losing weight during the 3 mo before the study did not lose more weight and patients who reported having an increased appetite before the study remained stable during the study. CONCLUSIONS: The nutritional intervention stabilized or slightly improved the anthropometric variables assessed; however, no significant change in body mass index occurred in 87% of patients. For the purpose of maintaining an acceptable nutritional status in patients who have Huntington's disease and normal nutritional status, we suggest oral nutritional supplements that contribute an average of 473 kcal/d in addition to a normal diet. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/16087319/Use_of_oral_nutritional_supplements_in_patients_with_Huntington's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(05)00158-9 DB - PRIME DP - Unbound Medicine ER -