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Does dietary folate intake modify effect of alcohol consumption on breast cancer risk? Prospective cohort study.
BMJ 2005; 331(7520):807BMJ

Abstract

OBJECTIVE

To evaluate the effect of dietary folate intake on the relation between alcohol consumption and breast cancer risk.

DESIGN

Prospective cohort study.

SETTING

Melbourne, Australia.

PARTICIPANTS

17,447 Anglo-Australian women resident in Melbourne, aged 40-69 years at recruitment in 1990-4, and followed up until 31 December 2003.

MAIN OUTCOME MEASURE

Invasive breast cancers diagnosed during follow-up and ascertained through the Victorian cancer registry.

RESULTS

537 invasive breast cancers were diagnosed. Compared with lifetime abstainers, the hazard ratio for breast cancer in women who consumed an average of 40 g or more of alcohol daily at baseline was 1.41 (95% confidence interval 0.90 to 2.23). No direct association was found between dietary folate intake and risk of breast cancer, but a high folate intake mitigated the excess risk associated with alcohol. The estimated hazard ratio of an alcohol consumption of 40 g/day or more was 2.00 (1.14 to 3.49) for women with intakes of 200 mug/day of folate and 0.77 (0.33 to 1.80) for 400 mug/day of folate (P = 0.04 for interaction between alcohol and folate).

CONCLUSIONS

An adequate dietary intake of folate might protect against the increased risk of breast cancer associated with alcohol consumption.

Authors+Show Affiliations

Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, 100 Drummond Street, Carlton, Victoria 3053, Australia. laura.baglietto@cancervic.org.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16087654

Citation

Baglietto, Laura, et al. "Does Dietary Folate Intake Modify Effect of Alcohol Consumption On Breast Cancer Risk? Prospective Cohort Study." BMJ (Clinical Research Ed.), vol. 331, no. 7520, 2005, p. 807.
Baglietto L, English DR, Gertig DM, et al. Does dietary folate intake modify effect of alcohol consumption on breast cancer risk? Prospective cohort study. BMJ. 2005;331(7520):807.
Baglietto, L., English, D. R., Gertig, D. M., Hopper, J. L., & Giles, G. G. (2005). Does dietary folate intake modify effect of alcohol consumption on breast cancer risk? Prospective cohort study. BMJ (Clinical Research Ed.), 331(7520), p. 807.
Baglietto L, et al. Does Dietary Folate Intake Modify Effect of Alcohol Consumption On Breast Cancer Risk? Prospective Cohort Study. BMJ. 2005 Oct 8;331(7520):807. PubMed PMID: 16087654.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does dietary folate intake modify effect of alcohol consumption on breast cancer risk? Prospective cohort study. AU - Baglietto,Laura, AU - English,Dallas R, AU - Gertig,Dorota M, AU - Hopper,John L, AU - Giles,Graham G, Y1 - 2005/08/08/ PY - 2005/8/10/pubmed PY - 2005/10/21/medline PY - 2005/8/10/entrez SP - 807 EP - 807 JF - BMJ (Clinical research ed.) JO - BMJ VL - 331 IS - 7520 N2 - OBJECTIVE: To evaluate the effect of dietary folate intake on the relation between alcohol consumption and breast cancer risk. DESIGN: Prospective cohort study. SETTING: Melbourne, Australia. PARTICIPANTS: 17,447 Anglo-Australian women resident in Melbourne, aged 40-69 years at recruitment in 1990-4, and followed up until 31 December 2003. MAIN OUTCOME MEASURE: Invasive breast cancers diagnosed during follow-up and ascertained through the Victorian cancer registry. RESULTS: 537 invasive breast cancers were diagnosed. Compared with lifetime abstainers, the hazard ratio for breast cancer in women who consumed an average of 40 g or more of alcohol daily at baseline was 1.41 (95% confidence interval 0.90 to 2.23). No direct association was found between dietary folate intake and risk of breast cancer, but a high folate intake mitigated the excess risk associated with alcohol. The estimated hazard ratio of an alcohol consumption of 40 g/day or more was 2.00 (1.14 to 3.49) for women with intakes of 200 mug/day of folate and 0.77 (0.33 to 1.80) for 400 mug/day of folate (P = 0.04 for interaction between alcohol and folate). CONCLUSIONS: An adequate dietary intake of folate might protect against the increased risk of breast cancer associated with alcohol consumption. SN - 1756-1833 UR - https://www.unboundmedicine.com/medline/citation/16087654/Does_dietary_folate_intake_modify_effect_of_alcohol_consumption_on_breast_cancer_risk_Prospective_cohort_study_ L2 - http://www.bmj.com/cgi/pmidlookup?view=long&pmid=16087654 DB - PRIME DP - Unbound Medicine ER -