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Fibrotic idiopathic interstitial pneumonia: high-resolution computed tomography considerations.
Semin Respir Crit Care Med. 2003 Aug; 24(4):365-76.SR

Abstract

The fibrotic idiopathic interstitial pneumonias comprise usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP). The characteristic high-resolution computed tomography findings of UIP are reticular abnormality and honeycombing with basal and peripheral predominance. Honeycombing is the strongest predictor of UIP. The extent of fibrosis on computed tomography (CT) is an important prognostic indicator in idiopathic pulmonary fibrosis (IPF). When ground-glass attenuation is seen in IPF it commonly progresses to fibrosis and honeycombing. Imaging may help to detect complications of IPF, including accelerated progression, lung cancer, and secondary infection. Our understanding of the clinical and radiological features of NSIP is still evolving. The CT finding of extensive ground-glass abnormality and some reticular abnormality, with basal and peripheral predominance, is strongly suggestive of NSIP. However, the CT appearances of NSIP overlap with those of UIP, organizing pneumonia (OP), and desquamative interstitial pneumonia (DIP), and biopsy may be necessary to sort this out. Other idiopathic pneumonias that may be associated with CT evidence of lung fibrosis include DIP, OP, acute interstitial pneumonia, and lymphoid interstitial pneumonia.

Authors+Show Affiliations

Department of Radiology, University of Colorado Health Sciences Center, School of Medicine, Denver, Colorado 80262, USA. David.lynch@uchsc.edu

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16088558

Citation

Lynch, David A.. "Fibrotic Idiopathic Interstitial Pneumonia: High-resolution Computed Tomography Considerations." Seminars in Respiratory and Critical Care Medicine, vol. 24, no. 4, 2003, pp. 365-76.
Lynch DA. Fibrotic idiopathic interstitial pneumonia: high-resolution computed tomography considerations. Semin Respir Crit Care Med. 2003;24(4):365-76.
Lynch, D. A. (2003). Fibrotic idiopathic interstitial pneumonia: high-resolution computed tomography considerations. Seminars in Respiratory and Critical Care Medicine, 24(4), 365-76.
Lynch DA. Fibrotic Idiopathic Interstitial Pneumonia: High-resolution Computed Tomography Considerations. Semin Respir Crit Care Med. 2003;24(4):365-76. PubMed PMID: 16088558.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fibrotic idiopathic interstitial pneumonia: high-resolution computed tomography considerations. A1 - Lynch,David A, PY - 2005/8/10/pubmed PY - 2005/8/10/medline PY - 2005/8/10/entrez SP - 365 EP - 76 JF - Seminars in respiratory and critical care medicine JO - Semin Respir Crit Care Med VL - 24 IS - 4 N2 - The fibrotic idiopathic interstitial pneumonias comprise usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP). The characteristic high-resolution computed tomography findings of UIP are reticular abnormality and honeycombing with basal and peripheral predominance. Honeycombing is the strongest predictor of UIP. The extent of fibrosis on computed tomography (CT) is an important prognostic indicator in idiopathic pulmonary fibrosis (IPF). When ground-glass attenuation is seen in IPF it commonly progresses to fibrosis and honeycombing. Imaging may help to detect complications of IPF, including accelerated progression, lung cancer, and secondary infection. Our understanding of the clinical and radiological features of NSIP is still evolving. The CT finding of extensive ground-glass abnormality and some reticular abnormality, with basal and peripheral predominance, is strongly suggestive of NSIP. However, the CT appearances of NSIP overlap with those of UIP, organizing pneumonia (OP), and desquamative interstitial pneumonia (DIP), and biopsy may be necessary to sort this out. Other idiopathic pneumonias that may be associated with CT evidence of lung fibrosis include DIP, OP, acute interstitial pneumonia, and lymphoid interstitial pneumonia. SN - 1069-3424 UR - https://www.unboundmedicine.com/medline/citation/16088558/Fibrotic_idiopathic_interstitial_pneumonia:_high_resolution_computed_tomography_considerations_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2003-42373 DB - PRIME DP - Unbound Medicine ER -
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