Tags

Type your tag names separated by a space and hit enter

Renin-angiotensin system gene polymorphisms and premature coronary heart disease.
J Renin Angiotensin Aldosterone Syst. 2005 Mar; 6(1):38-42.JR

Abstract

INTRODUCTION

Experimental and clinical studies demonstrated that the renin-angiotensin system (RAS) affects the pathogenesis of atherosclerosis and prognosis of coronary heart disease (CHD). The aim of this study was to investigate the genotype distribution and the allele frequencies of three RAS genes polymorphisms and their effects on premature CHD in a Turkish population.

MATERIALS AND METHODS

One-hundred and fifteen Turkish patients with premature CHD and 128 controls were included into the study. Angiotensin-converting enzyme (ACE), angiotensin II type 1 (AT1) receptor and angiotensinogen (AGT) gene polymorphisms were analysed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).

RESULTS

The patients group showed an increased frequency of the ACE D allele compared with controls (65% vs. 35%, p = 0.0001). There was a significant association between the DD genotype and premature CHD (ACE DD vs. ID and II; odds ratio [OR] = 2.82 [CI 95% 1.33 2.91, p = 0.002]). Also, we observed increased premature CHD risk associated with higher frequencies of the AGT MM genotype in patients when compared with controls (AGT MM vs. TT and MT, OR = 1.92 [CI 95% 1.11-3.33, p = 0.018]). We found a significant association between AT1-receptor AA genotype and decreased risk of premature CHD (AT1R AA vs. AC and CC, OR = 0.57[CI 95% 0.34-0.95, p = 0.03]).

CONCLUSIONS

We demonstrated that increased premature CHD risk is associated with higher frequencies of the ACE DD and AGT MM genotypes. These findings indicate a synergistic contribution of ACE DD and AGT MM polymorphisms to the development of premature CHD. Also, our results suggest that family history, smoking, diabetes, hypertension, obesity and ACE DD genotype were independent risk factors for premature CHD.

Authors+Show Affiliations

Department of Cardiology, Kent Hospital, Izmir, Turkey. csekuri@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16088850

Citation

Sekuri, Cevad, et al. "Renin-angiotensin System Gene Polymorphisms and Premature Coronary Heart Disease." Journal of the Renin-angiotensin-aldosterone System : JRAAS, vol. 6, no. 1, 2005, pp. 38-42.
Sekuri C, Cam FS, Ercan E, et al. Renin-angiotensin system gene polymorphisms and premature coronary heart disease. J Renin Angiotensin Aldosterone Syst. 2005;6(1):38-42.
Sekuri, C., Cam, F. S., Ercan, E., Tengiz, I., Sagcan, A., Eser, E., Berdeli, A., & Akin, M. (2005). Renin-angiotensin system gene polymorphisms and premature coronary heart disease. Journal of the Renin-angiotensin-aldosterone System : JRAAS, 6(1), 38-42.
Sekuri C, et al. Renin-angiotensin System Gene Polymorphisms and Premature Coronary Heart Disease. J Renin Angiotensin Aldosterone Syst. 2005;6(1):38-42. PubMed PMID: 16088850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Renin-angiotensin system gene polymorphisms and premature coronary heart disease. AU - Sekuri,Cevad, AU - Cam,F Sirri, AU - Ercan,Ertugrul, AU - Tengiz,Istemihan, AU - Sagcan,Abdi, AU - Eser,Erhan, AU - Berdeli,Afig, AU - Akin,Mustafa, PY - 2005/8/10/pubmed PY - 2005/8/24/medline PY - 2005/8/10/entrez SP - 38 EP - 42 JF - Journal of the renin-angiotensin-aldosterone system : JRAAS JO - J Renin Angiotensin Aldosterone Syst VL - 6 IS - 1 N2 - INTRODUCTION: Experimental and clinical studies demonstrated that the renin-angiotensin system (RAS) affects the pathogenesis of atherosclerosis and prognosis of coronary heart disease (CHD). The aim of this study was to investigate the genotype distribution and the allele frequencies of three RAS genes polymorphisms and their effects on premature CHD in a Turkish population. MATERIALS AND METHODS: One-hundred and fifteen Turkish patients with premature CHD and 128 controls were included into the study. Angiotensin-converting enzyme (ACE), angiotensin II type 1 (AT1) receptor and angiotensinogen (AGT) gene polymorphisms were analysed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). RESULTS: The patients group showed an increased frequency of the ACE D allele compared with controls (65% vs. 35%, p = 0.0001). There was a significant association between the DD genotype and premature CHD (ACE DD vs. ID and II; odds ratio [OR] = 2.82 [CI 95% 1.33 2.91, p = 0.002]). Also, we observed increased premature CHD risk associated with higher frequencies of the AGT MM genotype in patients when compared with controls (AGT MM vs. TT and MT, OR = 1.92 [CI 95% 1.11-3.33, p = 0.018]). We found a significant association between AT1-receptor AA genotype and decreased risk of premature CHD (AT1R AA vs. AC and CC, OR = 0.57[CI 95% 0.34-0.95, p = 0.03]). CONCLUSIONS: We demonstrated that increased premature CHD risk is associated with higher frequencies of the ACE DD and AGT MM genotypes. These findings indicate a synergistic contribution of ACE DD and AGT MM polymorphisms to the development of premature CHD. Also, our results suggest that family history, smoking, diabetes, hypertension, obesity and ACE DD genotype were independent risk factors for premature CHD. SN - 1470-3203 UR - https://www.unboundmedicine.com/medline/citation/16088850/Renin_angiotensin_system_gene_polymorphisms_and_premature_coronary_heart_disease_ L2 - https://journals.sagepub.com/doi/10.3317/jraas.2005.005?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -