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Differences in the enhancing effects of sodium caprate on colonic and jejunal drug absorption.
Pharm Res. 1992 May; 9(5):648-53.PR

Abstract

We examined the enhancing effect of sodium caprate (C10) on the jejunal absorption of a poorly absorbed drug, cefmetazole, in rats, in comparison with its colonic absorption (Pharm. Res. 5, 341-346, 1988). Jejunal absorption was significantly enhanced by C10, but to a smaller extent than colonic absorption. Membrane perturbation, caused by the interaction between C10 and membrane proteins or lipids, was shown to increase transcellular drug permeability, as reported in the colon. Paracellular permeabilities, obtained from the permeabilities of water-soluble nonelectrolytes of various molecular weights, showed a two-phase pattern against their free diffusion coefficients, suggesting the existence of at least two pore routes similar to those in the colon. C10 increased paracellular permeability in the colon but not in the jejunum. Impedance analysis and voltage clamp technique in the jejunum showed no significant effect of C10 on paracellular permeability, such as found in the colon. Accordingly, the difference in the effects of C10 on the jejunal and colonic absorption of cefmetazole was due mainly to the difference in its effects on the paracellular pathway.

Authors+Show Affiliations

Department of Biopharmaceutics, Tokyo College of Pharmacy, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1608897

Citation

Tomita, M, et al. "Differences in the Enhancing Effects of Sodium Caprate On Colonic and Jejunal Drug Absorption." Pharmaceutical Research, vol. 9, no. 5, 1992, pp. 648-53.
Tomita M, Sawada T, Ogawa T, et al. Differences in the enhancing effects of sodium caprate on colonic and jejunal drug absorption. Pharm Res. 1992;9(5):648-53.
Tomita, M., Sawada, T., Ogawa, T., Ouchi, H., Hayashi, M., & Awazu, S. (1992). Differences in the enhancing effects of sodium caprate on colonic and jejunal drug absorption. Pharmaceutical Research, 9(5), 648-53.
Tomita M, et al. Differences in the Enhancing Effects of Sodium Caprate On Colonic and Jejunal Drug Absorption. Pharm Res. 1992;9(5):648-53. PubMed PMID: 1608897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differences in the enhancing effects of sodium caprate on colonic and jejunal drug absorption. AU - Tomita,M, AU - Sawada,T, AU - Ogawa,T, AU - Ouchi,H, AU - Hayashi,M, AU - Awazu,S, PY - 1992/5/1/pubmed PY - 1992/5/1/medline PY - 1992/5/1/entrez SP - 648 EP - 53 JF - Pharmaceutical research JO - Pharm Res VL - 9 IS - 5 N2 - We examined the enhancing effect of sodium caprate (C10) on the jejunal absorption of a poorly absorbed drug, cefmetazole, in rats, in comparison with its colonic absorption (Pharm. Res. 5, 341-346, 1988). Jejunal absorption was significantly enhanced by C10, but to a smaller extent than colonic absorption. Membrane perturbation, caused by the interaction between C10 and membrane proteins or lipids, was shown to increase transcellular drug permeability, as reported in the colon. Paracellular permeabilities, obtained from the permeabilities of water-soluble nonelectrolytes of various molecular weights, showed a two-phase pattern against their free diffusion coefficients, suggesting the existence of at least two pore routes similar to those in the colon. C10 increased paracellular permeability in the colon but not in the jejunum. Impedance analysis and voltage clamp technique in the jejunum showed no significant effect of C10 on paracellular permeability, such as found in the colon. Accordingly, the difference in the effects of C10 on the jejunal and colonic absorption of cefmetazole was due mainly to the difference in its effects on the paracellular pathway. SN - 0724-8741 UR - https://www.unboundmedicine.com/medline/citation/1608897/Differences_in_the_enhancing_effects_of_sodium_caprate_on_colonic_and_jejunal_drug_absorption_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=1608897.ui DB - PRIME DP - Unbound Medicine ER -