Tags

Type your tag names separated by a space and hit enter

Soluble adhesion molecules (sICAM-1, sVCAM-1) and selectins (sE selectin, sP selectin, sL selectin) levels in children and adolescents with obesity, hypertension, and diabetes.
Metabolism. 2005 Aug; 54(8):1020-6.M

Abstract

The attachment of monocytes and lymphocytes to endothelial cells, which initiates atherosclerosis, arises under the influence of adhesion molecules. The preclinical phase of this disease lasts many decades, and this provides an opportunity for the presymptomatic detection of high-risk subjects. We evaluated levels of the adhesion molecules: sICAM-1 (soluble intercellular adhesion molecule 1), sVCAM-1 (soluble vascular adhesion molecule 1), sE selectin, sP selectin, and sL selectin in children with atherosclerosis risk factors (n = 123, mean age 15.1 years) (obese [n = 17], hypertensive [n = 25], obese with hypertension [n = 30], type 1 diabetic [n = 51]). Twenty-seven healthy children formed the control group, mean age 15.2 years. sICAM-1 was higher in the study group compared with control (314.1 +/- 61 vs 264.9 +/- 55 ng/mL, P < .01). The same was found for sVCAM-1 (513.7 +/- 187 vs 407.9 +/- 76 ng/mL, P < .05) and E selectin (86.04 +/- 33.6 vs 62.1 +/- 20.3 ng/mL, P < .01). sP-selectin and sL-selectin levels were not different compared with controls. E selectin correlated with body mass index (BMI; r = 0.18, P = .03), total cholesterol (r = 0.2, P = .016), and triglycerides (r = 0.22, P = .008). sICAM-1 correlated with BMI (r = 0.19, P = .019) and systolic blood pressure (r = 0.13, P = .045). In multiple linear regression analysis, sE selectin was found to be associated with triglycerides (R2 = 0.29, P = .045), sICAM-1 dependent on BMI (R2 = 0.58, P = .047), and sVCAM-1 dependent on total cholesterol (R2 = 0.51, P = .006). Elevated concentrations of sICAM-1, sVCAM-1, and E selectin were found in obese, hypertensive, and diabetic children. We conclude that endothelial activation appears in these children, and adhesion molecules are related to the earliest stages of atherosclerosis.

Authors+Show Affiliations

2nd Department of Children's Diseases, Medical University, 15-274 Bialystok, Poland. bglowinska@poczta.onet.plNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16092051

Citation

Glowinska, Barbara, et al. "Soluble Adhesion Molecules (sICAM-1, sVCAM-1) and Selectins (sE Selectin, sP Selectin, sL Selectin) Levels in Children and Adolescents With Obesity, Hypertension, and Diabetes." Metabolism: Clinical and Experimental, vol. 54, no. 8, 2005, pp. 1020-6.
Glowinska B, Urban M, Peczynska J, et al. Soluble adhesion molecules (sICAM-1, sVCAM-1) and selectins (sE selectin, sP selectin, sL selectin) levels in children and adolescents with obesity, hypertension, and diabetes. Metab Clin Exp. 2005;54(8):1020-6.
Glowinska, B., Urban, M., Peczynska, J., & Florys, B. (2005). Soluble adhesion molecules (sICAM-1, sVCAM-1) and selectins (sE selectin, sP selectin, sL selectin) levels in children and adolescents with obesity, hypertension, and diabetes. Metabolism: Clinical and Experimental, 54(8), 1020-6.
Glowinska B, et al. Soluble Adhesion Molecules (sICAM-1, sVCAM-1) and Selectins (sE Selectin, sP Selectin, sL Selectin) Levels in Children and Adolescents With Obesity, Hypertension, and Diabetes. Metab Clin Exp. 2005;54(8):1020-6. PubMed PMID: 16092051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soluble adhesion molecules (sICAM-1, sVCAM-1) and selectins (sE selectin, sP selectin, sL selectin) levels in children and adolescents with obesity, hypertension, and diabetes. AU - Glowinska,Barbara, AU - Urban,Miroslawa, AU - Peczynska,Jadwiga, AU - Florys,Bozena, PY - 2005/8/11/pubmed PY - 2005/10/12/medline PY - 2005/8/11/entrez SP - 1020 EP - 6 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 54 IS - 8 N2 - The attachment of monocytes and lymphocytes to endothelial cells, which initiates atherosclerosis, arises under the influence of adhesion molecules. The preclinical phase of this disease lasts many decades, and this provides an opportunity for the presymptomatic detection of high-risk subjects. We evaluated levels of the adhesion molecules: sICAM-1 (soluble intercellular adhesion molecule 1), sVCAM-1 (soluble vascular adhesion molecule 1), sE selectin, sP selectin, and sL selectin in children with atherosclerosis risk factors (n = 123, mean age 15.1 years) (obese [n = 17], hypertensive [n = 25], obese with hypertension [n = 30], type 1 diabetic [n = 51]). Twenty-seven healthy children formed the control group, mean age 15.2 years. sICAM-1 was higher in the study group compared with control (314.1 +/- 61 vs 264.9 +/- 55 ng/mL, P < .01). The same was found for sVCAM-1 (513.7 +/- 187 vs 407.9 +/- 76 ng/mL, P < .05) and E selectin (86.04 +/- 33.6 vs 62.1 +/- 20.3 ng/mL, P < .01). sP-selectin and sL-selectin levels were not different compared with controls. E selectin correlated with body mass index (BMI; r = 0.18, P = .03), total cholesterol (r = 0.2, P = .016), and triglycerides (r = 0.22, P = .008). sICAM-1 correlated with BMI (r = 0.19, P = .019) and systolic blood pressure (r = 0.13, P = .045). In multiple linear regression analysis, sE selectin was found to be associated with triglycerides (R2 = 0.29, P = .045), sICAM-1 dependent on BMI (R2 = 0.58, P = .047), and sVCAM-1 dependent on total cholesterol (R2 = 0.51, P = .006). Elevated concentrations of sICAM-1, sVCAM-1, and E selectin were found in obese, hypertensive, and diabetic children. We conclude that endothelial activation appears in these children, and adhesion molecules are related to the earliest stages of atherosclerosis. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/16092051/Soluble_adhesion_molecules__sICAM_1_sVCAM_1__and_selectins__sE_selectin_sP_selectin_sL_selectin__levels_in_children_and_adolescents_with_obesity_hypertension_and_diabetes_ DB - PRIME DP - Unbound Medicine ER -