Tags

Type your tag names separated by a space and hit enter

Steroid hormone receptor signaling in tumorigenesis.
J Cell Biochem. 2005 Oct 15; 96(3):490-505.JC

Abstract

Excessive activation of the hormone signaling pathways is implicated in several disorders of the target tissues, with cancer being one of the most serious fallouts. Steroid hormone receptors are key proteins through which steroid hormones convey their signals to the cells. Deregulated activity of the hormone receptors due to their altered activation; stability or sub-cellular localization is heavily implicated in the onset and progress of cancers. The role played by estrogen and its receptors in breast cancer remains the most thoroughly investigated steroid-dependent cancer system till date. Choosing it as an example, we have summarized the molecular mechanisms underlying the action of the estrogen receptors (ERs) in manifesting the effects of the estrogens in the cells. A special emphasis is placed on the molecular mechanism of their functionality, role of the coactivator proteins, and the reasons for the deregulated signaling. The therapeutic approaches resulting from the mechanistic study of the ER action and their efficacies are also discussed.

Authors+Show Affiliations

The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

16092128

Citation

Singh, Rajesh R., and Rakesh Kumar. "Steroid Hormone Receptor Signaling in Tumorigenesis." Journal of Cellular Biochemistry, vol. 96, no. 3, 2005, pp. 490-505.
Singh RR, Kumar R. Steroid hormone receptor signaling in tumorigenesis. J Cell Biochem. 2005;96(3):490-505.
Singh, R. R., & Kumar, R. (2005). Steroid hormone receptor signaling in tumorigenesis. Journal of Cellular Biochemistry, 96(3), 490-505.
Singh RR, Kumar R. Steroid Hormone Receptor Signaling in Tumorigenesis. J Cell Biochem. 2005 Oct 15;96(3):490-505. PubMed PMID: 16092128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Steroid hormone receptor signaling in tumorigenesis. AU - Singh,Rajesh R, AU - Kumar,Rakesh, PY - 2005/8/11/pubmed PY - 2005/12/13/medline PY - 2005/8/11/entrez SP - 490 EP - 505 JF - Journal of cellular biochemistry JO - J Cell Biochem VL - 96 IS - 3 N2 - Excessive activation of the hormone signaling pathways is implicated in several disorders of the target tissues, with cancer being one of the most serious fallouts. Steroid hormone receptors are key proteins through which steroid hormones convey their signals to the cells. Deregulated activity of the hormone receptors due to their altered activation; stability or sub-cellular localization is heavily implicated in the onset and progress of cancers. The role played by estrogen and its receptors in breast cancer remains the most thoroughly investigated steroid-dependent cancer system till date. Choosing it as an example, we have summarized the molecular mechanisms underlying the action of the estrogen receptors (ERs) in manifesting the effects of the estrogens in the cells. A special emphasis is placed on the molecular mechanism of their functionality, role of the coactivator proteins, and the reasons for the deregulated signaling. The therapeutic approaches resulting from the mechanistic study of the ER action and their efficacies are also discussed. SN - 0730-2312 UR - https://www.unboundmedicine.com/medline/citation/16092128/Steroid_hormone_receptor_signaling_in_tumorigenesis_ L2 - https://doi.org/10.1002/jcb.20566 DB - PRIME DP - Unbound Medicine ER -