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Mastocytosis and adverse reactions to biogenic amines and histamine-releasing foods: what is the evidence?

Abstract

BACKGROUND

It has been suggested that normal concentrations of biogenic amines and 'histamine-releasing foods' may exacerbate symptoms in mastocytosis. The purpose of this study was to look for scientific evidence in the literature on diets restricted in biogenic amines and histamine-releasing foods in the treatment of mastocytosis.

METHODS

Medline (1966 to 2004), Cinahl (1982 to 2004) and the Cochraine Library were searched for double-blind placebo-controlled food challenge (DBPCFC) studies with biogenic amines and/or histamine-releasing foods in mastocytosis.

RESULTS

No studies employing DBPCFC with dietary biogenic amines or histamine-releasing foods in mastocytosis were found. Only a few in vitro studies in other diseases, animal studies and studies in humans in which histamine-releasing agents were incubated directly with duodenal tissues were found. One case was reported of severe adverse reactions to alcohol in mastocytosis, objectified by an open challenge.

CONCLUSION

Despite the widespread belief that biogenic amines and histamine-releasing foods may cause allergy-like, non-IgE-mediated symptoms in certain patients, the role of diets restricted in biogenic amines and histamine-releasing foods in the treatment of mastosytosis remains hypothetical but worthy of further investigation. There is some evidence for adverse reactions to alcohol in mastocytosis.

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  • Authors+Show Affiliations

    ,

    Beatrix Children's Hospital, University Medical Centre Groningen, Netherlands.

    , , ,

    Source

    MeSH

    Animals
    Biogenic Amines
    Eggs
    Food Contamination
    Histamine
    Humans
    Mastocytosis
    Methylhistamines
    Shellfish
    Wine

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review

    Language

    eng

    PubMed ID

    16093574

    Citation

    Vlieg-Boerstra, B J., et al. "Mastocytosis and Adverse Reactions to Biogenic Amines and Histamine-releasing Foods: what Is the Evidence?" The Netherlands Journal of Medicine, vol. 63, no. 7, 2005, pp. 244-9.
    Vlieg-Boerstra BJ, van der Heide S, Oude Elberink JN, et al. Mastocytosis and adverse reactions to biogenic amines and histamine-releasing foods: what is the evidence? Neth J Med. 2005;63(7):244-9.
    Vlieg-Boerstra, B. J., van der Heide, S., Oude Elberink, J. N., Kluin-Nelemans, J. C., & Dubois, A. E. (2005). Mastocytosis and adverse reactions to biogenic amines and histamine-releasing foods: what is the evidence? The Netherlands Journal of Medicine, 63(7), pp. 244-9.
    Vlieg-Boerstra BJ, et al. Mastocytosis and Adverse Reactions to Biogenic Amines and Histamine-releasing Foods: what Is the Evidence. Neth J Med. 2005;63(7):244-9. PubMed PMID: 16093574.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Mastocytosis and adverse reactions to biogenic amines and histamine-releasing foods: what is the evidence? AU - Vlieg-Boerstra,B J, AU - van der Heide,S, AU - Oude Elberink,J N G, AU - Kluin-Nelemans,J C, AU - Dubois,A E J, PY - 2005/8/12/pubmed PY - 2005/9/21/medline PY - 2005/8/12/entrez SP - 244 EP - 9 JF - The Netherlands journal of medicine JO - Neth J Med VL - 63 IS - 7 N2 - BACKGROUND: It has been suggested that normal concentrations of biogenic amines and 'histamine-releasing foods' may exacerbate symptoms in mastocytosis. The purpose of this study was to look for scientific evidence in the literature on diets restricted in biogenic amines and histamine-releasing foods in the treatment of mastocytosis. METHODS: Medline (1966 to 2004), Cinahl (1982 to 2004) and the Cochraine Library were searched for double-blind placebo-controlled food challenge (DBPCFC) studies with biogenic amines and/or histamine-releasing foods in mastocytosis. RESULTS: No studies employing DBPCFC with dietary biogenic amines or histamine-releasing foods in mastocytosis were found. Only a few in vitro studies in other diseases, animal studies and studies in humans in which histamine-releasing agents were incubated directly with duodenal tissues were found. One case was reported of severe adverse reactions to alcohol in mastocytosis, objectified by an open challenge. CONCLUSION: Despite the widespread belief that biogenic amines and histamine-releasing foods may cause allergy-like, non-IgE-mediated symptoms in certain patients, the role of diets restricted in biogenic amines and histamine-releasing foods in the treatment of mastosytosis remains hypothetical but worthy of further investigation. There is some evidence for adverse reactions to alcohol in mastocytosis. SN - 0300-2977 UR - https://www.unboundmedicine.com/medline/citation/16093574/Mastocytosis_and_adverse_reactions_to_biogenic_amines_and_histamine_releasing_foods:_what_is_the_evidence L2 - http://www.njmonline.nl/njm/getarticle.php?v=63&i=7&p=244 DB - PRIME DP - Unbound Medicine ER -