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The effect of taurine or betaine pretreatment on hepatotoxicity and prooxidant status induced by lipopolysaccharide treatment in the liver of rats.
Eur J Gastroenterol Hepatol 2005; 17(9):917-21EJ

Abstract

BACKGROUND

Taurine or betaine have been reported to have antioxidative potential and inhibit Kupffer cell activation. These effects may play an important role in their hepatoprotective effects. Therefore, they may also have protective effects in lipopolysaccharide hepatotoxicity by both inhibiting Kupffer cell activation and behaving as antioxidants.

DESIGN

The prophylactic efficiency of taurine or betaine pretreatment for the prevention of peroxidative changes induced by lipopolysaccharide treatment in the rat liver was investigated.

METHODS

Lipopolysaccharide (10 mg/kg intraperitoneally) was given to rats pretreated with taurine (1.5%, w/v) or betaine (1.5%, w/v) in drinking water for 4 weeks and plasma transaminase activities as well as hepatic malondialdehyde, diene conjugate (DC), glutathione, alpha-tocopherol and ascorbic acid levels, and superoxide dismutase (SOD) and glutathione peroxidase activities were determined.

RESULTS

Significant increases in plasma transaminase activities and hepatic malondialdehyde and DC levels and decreases in hepatic glutathione and alpha-tocopherol levels and SOD and glutathione peroxidase activities were observed 6 h after lipopolysaccharide treatment. This treatment did not alter ascorbic acid levels in the liver compared with controls. Taurine or betaine pretreatment in lipopolysaccharide-injected rats caused significant decreases in plasma transaminase activities and hepatic malondialdehyde and DC levels, and significant increases in glutathione and alpha-tocopherol (not betaine) levels without changing ascorbic acid levels and SOD and glutathione peroxidase activities in the liver.

CONCLUSIONS

Our findings clearly indicate that taurine or betaine pretreatment was effective in the prevention of lipopolysaccharide-induced hepatotoxicity and prooxidant status.

Authors+Show Affiliations

Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa 34093 Istanbul, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16093868

Citation

Balkan, Jale, et al. "The Effect of Taurine or Betaine Pretreatment On Hepatotoxicity and Prooxidant Status Induced By Lipopolysaccharide Treatment in the Liver of Rats." European Journal of Gastroenterology & Hepatology, vol. 17, no. 9, 2005, pp. 917-21.
Balkan J, Parldar FH, Doğru-Abbasoğlu S, et al. The effect of taurine or betaine pretreatment on hepatotoxicity and prooxidant status induced by lipopolysaccharide treatment in the liver of rats. Eur J Gastroenterol Hepatol. 2005;17(9):917-21.
Balkan, J., Parldar, F. H., Doğru-Abbasoğlu, S., Aykaç-Toker, G., & Uysal, M. (2005). The effect of taurine or betaine pretreatment on hepatotoxicity and prooxidant status induced by lipopolysaccharide treatment in the liver of rats. European Journal of Gastroenterology & Hepatology, 17(9), pp. 917-21.
Balkan J, et al. The Effect of Taurine or Betaine Pretreatment On Hepatotoxicity and Prooxidant Status Induced By Lipopolysaccharide Treatment in the Liver of Rats. Eur J Gastroenterol Hepatol. 2005;17(9):917-21. PubMed PMID: 16093868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of taurine or betaine pretreatment on hepatotoxicity and prooxidant status induced by lipopolysaccharide treatment in the liver of rats. AU - Balkan,Jale, AU - Parldar,Fatma Hande, AU - Doğru-Abbasoğlu,Semra, AU - Aykaç-Toker,Gülçin, AU - Uysal,Müjdat, PY - 2005/8/12/pubmed PY - 2006/2/14/medline PY - 2005/8/12/entrez SP - 917 EP - 21 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 17 IS - 9 N2 - BACKGROUND: Taurine or betaine have been reported to have antioxidative potential and inhibit Kupffer cell activation. These effects may play an important role in their hepatoprotective effects. Therefore, they may also have protective effects in lipopolysaccharide hepatotoxicity by both inhibiting Kupffer cell activation and behaving as antioxidants. DESIGN: The prophylactic efficiency of taurine or betaine pretreatment for the prevention of peroxidative changes induced by lipopolysaccharide treatment in the rat liver was investigated. METHODS: Lipopolysaccharide (10 mg/kg intraperitoneally) was given to rats pretreated with taurine (1.5%, w/v) or betaine (1.5%, w/v) in drinking water for 4 weeks and plasma transaminase activities as well as hepatic malondialdehyde, diene conjugate (DC), glutathione, alpha-tocopherol and ascorbic acid levels, and superoxide dismutase (SOD) and glutathione peroxidase activities were determined. RESULTS: Significant increases in plasma transaminase activities and hepatic malondialdehyde and DC levels and decreases in hepatic glutathione and alpha-tocopherol levels and SOD and glutathione peroxidase activities were observed 6 h after lipopolysaccharide treatment. This treatment did not alter ascorbic acid levels in the liver compared with controls. Taurine or betaine pretreatment in lipopolysaccharide-injected rats caused significant decreases in plasma transaminase activities and hepatic malondialdehyde and DC levels, and significant increases in glutathione and alpha-tocopherol (not betaine) levels without changing ascorbic acid levels and SOD and glutathione peroxidase activities in the liver. CONCLUSIONS: Our findings clearly indicate that taurine or betaine pretreatment was effective in the prevention of lipopolysaccharide-induced hepatotoxicity and prooxidant status. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/16093868/The_effect_of_taurine_or_betaine_pretreatment_on_hepatotoxicity_and_prooxidant_status_induced_by_lipopolysaccharide_treatment_in_the_liver_of_rats_ L2 - http://Insights.ovid.com/pubmed?pmid=16093868 DB - PRIME DP - Unbound Medicine ER -