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Prostate specific antigen levels in young adulthood predict prostate cancer risk: results from a cohort of Black and White Americans.
J Urol 2005; 174(3):872-6; discussion 876JU

Abstract

PURPOSE

Prostate specific antigen (PSA) is a serine protease produced by normal and malignant prostate epithelial cells. Serum PSA increases with age, due largely to age related increases in the prevalence of benign prostatic disease. Little is known about PSA distribution in young adulthood, when benign and malignant prostatic diseases are rare, or about how PSA within the normal range in youth relates to subsequent prostate cancer risk.

MATERIALS AND METHODS

We evaluated serum PSA and subsequent prostate cancer occurrence in a cohort of young black and white American men with a median age at blood draw of 34 years, who in 1959 to 1966 participated as the fathers of newborns enrolled in the Child Health and Development Study, and who were followed for several decades for prostate cancer. We examined associations between PSA in young adulthood and subsequent prostate cancer risk using a nested case-control design based on 119 black and 206 white cases with 2 control men matched to each case on race and year of birth.

RESULTS

Prostate cancer risk increased with increasing PSA in black and white men. The OR comparing risk in the highest to lowest quartiles of PSA was 4.4 (95% CI 2.0 to 9.6) in black men and 3.5 (95% CI 2.0 to 6.1) in white men. ORs relating risk to PSA were higher when analysis was restricted to cases diagnosed before age 65 years.

CONCLUSIONS

These findings suggest that PSA levels in young adulthood indicate increased risk of prostate cancer and, thus, they may be useful for targeting men for screening and early diagnosis.

Authors+Show Affiliations

Department of Health Research and Policy, Stanford University School of Medicine, California 94305-5405, USA. alicesw@stanford.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16093978

Citation

Whittemore, Alice S., et al. "Prostate Specific Antigen Levels in Young Adulthood Predict Prostate Cancer Risk: Results From a Cohort of Black and White Americans." The Journal of Urology, vol. 174, no. 3, 2005, pp. 872-6; discussion 876.
Whittemore AS, Cirillo PM, Feldman D, et al. Prostate specific antigen levels in young adulthood predict prostate cancer risk: results from a cohort of Black and White Americans. J Urol. 2005;174(3):872-6; discussion 876.
Whittemore, A. S., Cirillo, P. M., Feldman, D., & Cohn, B. A. (2005). Prostate specific antigen levels in young adulthood predict prostate cancer risk: results from a cohort of Black and White Americans. The Journal of Urology, 174(3), pp. 872-6; discussion 876.
Whittemore AS, et al. Prostate Specific Antigen Levels in Young Adulthood Predict Prostate Cancer Risk: Results From a Cohort of Black and White Americans. J Urol. 2005;174(3):872-6; discussion 876. PubMed PMID: 16093978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prostate specific antigen levels in young adulthood predict prostate cancer risk: results from a cohort of Black and White Americans. AU - Whittemore,Alice S, AU - Cirillo,Piera M, AU - Feldman,David, AU - Cohn,Barbara A, PY - 2005/8/12/pubmed PY - 2005/9/29/medline PY - 2005/8/12/entrez SP - 872-6; discussion 876 JF - The Journal of urology JO - J. Urol. VL - 174 IS - 3 N2 - PURPOSE: Prostate specific antigen (PSA) is a serine protease produced by normal and malignant prostate epithelial cells. Serum PSA increases with age, due largely to age related increases in the prevalence of benign prostatic disease. Little is known about PSA distribution in young adulthood, when benign and malignant prostatic diseases are rare, or about how PSA within the normal range in youth relates to subsequent prostate cancer risk. MATERIALS AND METHODS: We evaluated serum PSA and subsequent prostate cancer occurrence in a cohort of young black and white American men with a median age at blood draw of 34 years, who in 1959 to 1966 participated as the fathers of newborns enrolled in the Child Health and Development Study, and who were followed for several decades for prostate cancer. We examined associations between PSA in young adulthood and subsequent prostate cancer risk using a nested case-control design based on 119 black and 206 white cases with 2 control men matched to each case on race and year of birth. RESULTS: Prostate cancer risk increased with increasing PSA in black and white men. The OR comparing risk in the highest to lowest quartiles of PSA was 4.4 (95% CI 2.0 to 9.6) in black men and 3.5 (95% CI 2.0 to 6.1) in white men. ORs relating risk to PSA were higher when analysis was restricted to cases diagnosed before age 65 years. CONCLUSIONS: These findings suggest that PSA levels in young adulthood indicate increased risk of prostate cancer and, thus, they may be useful for targeting men for screening and early diagnosis. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/16093978/Prostate_specific_antigen_levels_in_young_adulthood_predict_prostate_cancer_risk:_results_from_a_cohort_of_Black_and_White_Americans_ L2 - https://www.jurology.com/doi/full/10.1097/01.ju.0000169262.18000.8a?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -