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The effect of natural pollen exposure on eosinophil apoptosis and its relationship to bronchial hyperresponsiveness in patients with seasonal allergic rhinitis.
Ann Allergy Asthma Immunol. 2005 Jul; 95(1):72-8.AA

Abstract

BACKGROUND

Limited data suggest that there is increased eosinophilic inflammation in the airways of patients with seasonal allergic rhinitis (SAR) during pollen season even if they do not have asthma.

OBJECTIVE

To investigate the effect of natural pollen exposure on inflammatory cells and apoptosis of eosinophils and its association with bronchial hyperresponsiveness (BHR) during and out of pollen season in SAR patients sensitized to only grass pollens.

METHODS

Forty SAR patients and 10 patients with nonallergic rhinitis (NAR) from Ankara, Turkey, were recruited to participate in the study. Two induced sputum samples were taken from SAR patients during pollen season (May-June) and out of pollen season (November-January), but only 1 induced sputum sample was taken from NAR patients. Slides of induced sputum were evaluated by 2 cytologists with the use of light microscopy after cytocentrifuged and dyed with May-Grünwald-Giemsa stain. Induced sputum samples were sufficient for differential cell counts in 14 SAR and 7 NAR patients.

RESULTS

Eosinophil counts in SAR patients were statistically higher in pollen season (19.4% +/- 16.2%) compared with out of season (4.6% +/- 6.9%, P = .003) and with NAR patients (4.7% +/- 9.5%, P = .01). The apoptotic eosinophil counts in SAR patients were statistically higher out of pollen season (3.0% +/- 4.5%) than in pollen season (0.38% +/- 0.80%, P = .02) and higher than those of NAR patients (0.14% +/- 0.26%, P = .005). The apoptotic ratio was statistically higher after pollen season compared with pollen season (0.720% +/- 0.394% vs 0.044% +/- 0.116%, P = .002). Blood eosinophil counts of SAR patients were increased during the pollen season (364 +/- 187/mm3) compared with out of season (278 +/- 219/mm3, P = .04) and with NAR patients (85 +/- 54/mm3, P = .001). The number of SAR patients who had BHR during the pollen season (7/14) was higher than the number who had BHR out of season (2/14, chi2 = 4.2, P = .04).

CONCLUSION

Our data indicate that changes in eosinophil counts and eosinophil apoptosis may be related to the changes of natural pollen exposure and seasonal changes of BHR in SAR patients.

Authors+Show Affiliations

Kurt E
Department of Allergic Diseases, Ankara University, Medical Faculty, Ankara, Turkey. emelharm@yahoo.com
Bavbek S
No affiliation info available
Aksu O
No affiliation info available
Erekul S
No affiliation info available
Misirligil Z
No affiliation info available

MeSH

AdolescentAdultApoptosisBronchial HyperreactivityEnvironmental ExposureEosinophilsFemaleHumansLeukocyte CountMaleMiddle AgedPollenRhinitis, Allergic, SeasonalSeasonsSputum

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16095145

Citation

Kurt, Emel, et al. "The Effect of Natural Pollen Exposure On Eosinophil Apoptosis and Its Relationship to Bronchial Hyperresponsiveness in Patients With Seasonal Allergic Rhinitis." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 95, no. 1, 2005, pp. 72-8.
Kurt E, Bavbek S, Aksu O, et al. The effect of natural pollen exposure on eosinophil apoptosis and its relationship to bronchial hyperresponsiveness in patients with seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 2005;95(1):72-8.
Kurt, E., Bavbek, S., Aksu, O., Erekul, S., & Misirligil, Z. (2005). The effect of natural pollen exposure on eosinophil apoptosis and its relationship to bronchial hyperresponsiveness in patients with seasonal allergic rhinitis. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 95(1), 72-8.
Kurt E, et al. The Effect of Natural Pollen Exposure On Eosinophil Apoptosis and Its Relationship to Bronchial Hyperresponsiveness in Patients With Seasonal Allergic Rhinitis. Ann Allergy Asthma Immunol. 2005;95(1):72-8. PubMed PMID: 16095145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of natural pollen exposure on eosinophil apoptosis and its relationship to bronchial hyperresponsiveness in patients with seasonal allergic rhinitis. AU - Kurt,Emel, AU - Bavbek,Sevim, AU - Aksu,Ozhan, AU - Erekul,Selim, AU - Misirligil,Zeynep, PY - 2005/8/13/pubmed PY - 2005/9/8/medline PY - 2005/8/13/entrez SP - 72 EP - 8 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann Allergy Asthma Immunol VL - 95 IS - 1 N2 - BACKGROUND: Limited data suggest that there is increased eosinophilic inflammation in the airways of patients with seasonal allergic rhinitis (SAR) during pollen season even if they do not have asthma. OBJECTIVE: To investigate the effect of natural pollen exposure on inflammatory cells and apoptosis of eosinophils and its association with bronchial hyperresponsiveness (BHR) during and out of pollen season in SAR patients sensitized to only grass pollens. METHODS: Forty SAR patients and 10 patients with nonallergic rhinitis (NAR) from Ankara, Turkey, were recruited to participate in the study. Two induced sputum samples were taken from SAR patients during pollen season (May-June) and out of pollen season (November-January), but only 1 induced sputum sample was taken from NAR patients. Slides of induced sputum were evaluated by 2 cytologists with the use of light microscopy after cytocentrifuged and dyed with May-Grünwald-Giemsa stain. Induced sputum samples were sufficient for differential cell counts in 14 SAR and 7 NAR patients. RESULTS: Eosinophil counts in SAR patients were statistically higher in pollen season (19.4% +/- 16.2%) compared with out of season (4.6% +/- 6.9%, P = .003) and with NAR patients (4.7% +/- 9.5%, P = .01). The apoptotic eosinophil counts in SAR patients were statistically higher out of pollen season (3.0% +/- 4.5%) than in pollen season (0.38% +/- 0.80%, P = .02) and higher than those of NAR patients (0.14% +/- 0.26%, P = .005). The apoptotic ratio was statistically higher after pollen season compared with pollen season (0.720% +/- 0.394% vs 0.044% +/- 0.116%, P = .002). Blood eosinophil counts of SAR patients were increased during the pollen season (364 +/- 187/mm3) compared with out of season (278 +/- 219/mm3, P = .04) and with NAR patients (85 +/- 54/mm3, P = .001). The number of SAR patients who had BHR during the pollen season (7/14) was higher than the number who had BHR out of season (2/14, chi2 = 4.2, P = .04). CONCLUSION: Our data indicate that changes in eosinophil counts and eosinophil apoptosis may be related to the changes of natural pollen exposure and seasonal changes of BHR in SAR patients. SN - 1081-1206 UR - https://www.unboundmedicine.com/medline/citation/16095145/The_effect_of_natural_pollen_exposure_on_eosinophil_apoptosis_and_its_relationship_to_bronchial_hyperresponsiveness_in_patients_with_seasonal_allergic_rhinitis_ DB - PRIME DP - Unbound Medicine ER -