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Acute effect of single-dose cadmium treatment on lipid peroxidation and antioxidant enzymes in ovariectomized rats.
Ecotoxicol Environ Saf. 2006 Sep; 65(1):140-4.EE

Abstract

We investigated the acute effect of single-dose cadmium (Cd) treatment on lipid peroxidation and antioxidant enzymes in liver and kidney of rats following an ovariectomy operation. Twenty-eight female Wistar albino rats were used and were divided into four groups: I, control (n=7); II, cadmium (Cd, n=7); III, ovariectomized (Ovx, n=7); and IV, ovariectomized+cadmium (Ovx-Cd, n=7). Fourteen of the rats were ovariectomized. Twelve weeks later, cadmium chloride (CdCl(2), 5 mg/kg) was administered i.p. as a single dose to the Cd and Ovx-Cd groups. Twenty-four hours after the injection, all rats were sacrificed and had their liver and kidney tissues removed for the measurement of superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) levels. SOD activity showed a significant decrease (P<0.001) in both organs of Ovx and Cd rats in comparison to controls. CAT activity was significantly decreased (P<0.01) in the liver of Ovx and Cd groups but not in the kidneys of both groups compared to control values. MDA concentrations were higher (P<0.05) in both organs of Ovx and Cd rats than those values observed in the control group. Similar patterns of changes were observed in the Ovx-Cd rats, but the increase in the MDA levels and the decrease in the antioxidant enzymes for the Ovx-Cd group were higher than those of the Ovx and Cd groups. Based on the data, it can be stated that cadmium increases the effect of ovariectomy on lipid peroxidation, impairs the antioxidant defense system, and induces oxidative stress.

Authors+Show Affiliations

Department of Biochemistry, Mersin University Pharmacy School, Mersin 33169, Turkey. syalin01@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16095692

Citation

Yalin, Serap, et al. "Acute Effect of Single-dose Cadmium Treatment On Lipid Peroxidation and Antioxidant Enzymes in Ovariectomized Rats." Ecotoxicology and Environmental Safety, vol. 65, no. 1, 2006, pp. 140-4.
Yalin S, Comelekoglu U, Bagis S, et al. Acute effect of single-dose cadmium treatment on lipid peroxidation and antioxidant enzymes in ovariectomized rats. Ecotoxicol Environ Saf. 2006;65(1):140-4.
Yalin, S., Comelekoglu, U., Bagis, S., Sahin, N. O., Ogenler, O., & Hatungil, R. (2006). Acute effect of single-dose cadmium treatment on lipid peroxidation and antioxidant enzymes in ovariectomized rats. Ecotoxicology and Environmental Safety, 65(1), 140-4.
Yalin S, et al. Acute Effect of Single-dose Cadmium Treatment On Lipid Peroxidation and Antioxidant Enzymes in Ovariectomized Rats. Ecotoxicol Environ Saf. 2006;65(1):140-4. PubMed PMID: 16095692.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute effect of single-dose cadmium treatment on lipid peroxidation and antioxidant enzymes in ovariectomized rats. AU - Yalin,Serap, AU - Comelekoglu,Ulku, AU - Bagis,Selda, AU - Sahin,N Ozlen, AU - Ogenler,Oya, AU - Hatungil,Rezan, Y1 - 2005/08/10/ PY - 2004/10/20/received PY - 2005/03/30/revised PY - 2005/06/15/accepted PY - 2005/8/13/pubmed PY - 2007/2/1/medline PY - 2005/8/13/entrez SP - 140 EP - 4 JF - Ecotoxicology and environmental safety JO - Ecotoxicol Environ Saf VL - 65 IS - 1 N2 - We investigated the acute effect of single-dose cadmium (Cd) treatment on lipid peroxidation and antioxidant enzymes in liver and kidney of rats following an ovariectomy operation. Twenty-eight female Wistar albino rats were used and were divided into four groups: I, control (n=7); II, cadmium (Cd, n=7); III, ovariectomized (Ovx, n=7); and IV, ovariectomized+cadmium (Ovx-Cd, n=7). Fourteen of the rats were ovariectomized. Twelve weeks later, cadmium chloride (CdCl(2), 5 mg/kg) was administered i.p. as a single dose to the Cd and Ovx-Cd groups. Twenty-four hours after the injection, all rats were sacrificed and had their liver and kidney tissues removed for the measurement of superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) levels. SOD activity showed a significant decrease (P<0.001) in both organs of Ovx and Cd rats in comparison to controls. CAT activity was significantly decreased (P<0.01) in the liver of Ovx and Cd groups but not in the kidneys of both groups compared to control values. MDA concentrations were higher (P<0.05) in both organs of Ovx and Cd rats than those values observed in the control group. Similar patterns of changes were observed in the Ovx-Cd rats, but the increase in the MDA levels and the decrease in the antioxidant enzymes for the Ovx-Cd group were higher than those of the Ovx and Cd groups. Based on the data, it can be stated that cadmium increases the effect of ovariectomy on lipid peroxidation, impairs the antioxidant defense system, and induces oxidative stress. SN - 0147-6513 UR - https://www.unboundmedicine.com/medline/citation/16095692/Acute_effect_of_single_dose_cadmium_treatment_on_lipid_peroxidation_and_antioxidant_enzymes_in_ovariectomized_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0147-6513(05)00163-6 DB - PRIME DP - Unbound Medicine ER -