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Preparation and characterization of inclusion complexes of prazosin hydrochloride with beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin.
J Pharm Biomed Anal. 2006 Jan 23; 40(1):122-7.JP

Abstract

The slightly water-soluble drug prazosin hydrochloride (PRH) and its inclusion with either beta-cyclodextrin (betaCD) or hydroxypropyl-beta-cyclodextrin (HPbetaCD) were investigated. The phase solubility profiles of PRH with betaCD and HPbetaCD were classified as B(s)- and A(L)-types, respectively. Stability constants with 1:1 molar ratio were calculated from the phase solubility diagrams and the solubility of PRH could be enhanced by 27.6% for betaCD and 226.4% for HPbetaCD, respectively. Binary systems of PRH with betaCD or HPbetaCD prepared by various methods were characterized by differential scanning calorimetry and Fourier transformation-infrared spectroscopy. It could be concluded that PRH could form inclusion complex with either betaCD or HPbetaCD. The dissolution profiles of inclusion complexes were determined and compared with those of PRH alone and their physical mixtures. The dissolution rate of PRH was increased by betaCD and HPbetaCD inclusion complexation remarkably. Both the preparation technique and nature of the carriers played important roles in the dissolution performance of the systems. All the systems with HPbetaCD showed better performance than the corresponding ones with betaCD.

Authors+Show Affiliations

Zhejiang University, College of Pharmaceutical Science, Hangzhou 310027, People's Republic of China. liulx@zju.edu.cnNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16095859

Citation

Liu, Longxiao, and Suyan Zhu. "Preparation and Characterization of Inclusion Complexes of Prazosin Hydrochloride With Beta-cyclodextrin and Hydroxypropyl-beta-cyclodextrin." Journal of Pharmaceutical and Biomedical Analysis, vol. 40, no. 1, 2006, pp. 122-7.
Liu L, Zhu S. Preparation and characterization of inclusion complexes of prazosin hydrochloride with beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin. J Pharm Biomed Anal. 2006;40(1):122-7.
Liu, L., & Zhu, S. (2006). Preparation and characterization of inclusion complexes of prazosin hydrochloride with beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin. Journal of Pharmaceutical and Biomedical Analysis, 40(1), 122-7.
Liu L, Zhu S. Preparation and Characterization of Inclusion Complexes of Prazosin Hydrochloride With Beta-cyclodextrin and Hydroxypropyl-beta-cyclodextrin. J Pharm Biomed Anal. 2006 Jan 23;40(1):122-7. PubMed PMID: 16095859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and characterization of inclusion complexes of prazosin hydrochloride with beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin. AU - Liu,Longxiao, AU - Zhu,Suyan, Y1 - 2005/08/10/ PY - 2005/04/01/received PY - 2005/06/19/revised PY - 2005/06/20/accepted PY - 2005/8/13/pubmed PY - 2006/6/7/medline PY - 2005/8/13/entrez SP - 122 EP - 7 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 40 IS - 1 N2 - The slightly water-soluble drug prazosin hydrochloride (PRH) and its inclusion with either beta-cyclodextrin (betaCD) or hydroxypropyl-beta-cyclodextrin (HPbetaCD) were investigated. The phase solubility profiles of PRH with betaCD and HPbetaCD were classified as B(s)- and A(L)-types, respectively. Stability constants with 1:1 molar ratio were calculated from the phase solubility diagrams and the solubility of PRH could be enhanced by 27.6% for betaCD and 226.4% for HPbetaCD, respectively. Binary systems of PRH with betaCD or HPbetaCD prepared by various methods were characterized by differential scanning calorimetry and Fourier transformation-infrared spectroscopy. It could be concluded that PRH could form inclusion complex with either betaCD or HPbetaCD. The dissolution profiles of inclusion complexes were determined and compared with those of PRH alone and their physical mixtures. The dissolution rate of PRH was increased by betaCD and HPbetaCD inclusion complexation remarkably. Both the preparation technique and nature of the carriers played important roles in the dissolution performance of the systems. All the systems with HPbetaCD showed better performance than the corresponding ones with betaCD. SN - 0731-7085 UR - https://www.unboundmedicine.com/medline/citation/16095859/Preparation_and_characterization_of_inclusion_complexes_of_prazosin_hydrochloride_with_beta_cyclodextrin_and_hydroxypropyl_beta_cyclodextrin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731-7085(05)00423-1 DB - PRIME DP - Unbound Medicine ER -