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Femal, a herbal remedy made from pollen extracts, reduces hot flushes and improves quality of life in menopausal women: a randomized, placebo-controlled, parallel study.
Climacteric. 2005 Jun; 8(2):162-70.C

Abstract

BACKGROUND

The fact that hormone replacement therapy has been claimed to increase the risk of breast cancer has made it relevant to search for new non-hormonal treatments of menopausal symptoms.

OBJECTIVES

This study aimed to evaluate whether Femal, a herbal remedy made from pollen extracts, alleviates the symptoms of the menopause, especially hot flushes.

DESIGN

A randomized, double-blind, placebo-controlled, parallel trial of 64 menopausal women, of whom 54 completed the trial. After an initial run-in phase of 1 month, the women were randomly given either two Femal tablets each morning, or two identical placebo tablets, for 3 months of treatment. On inclusion, and then at 4-week intervals, the patients were asked to evaluate 16 symptoms of the menopause using Menopause Rating Scales (MRS). In addition, every day throughout the study, certain menopausal symptoms were recorded in a diary.

RESULTS

The two treatment groups were identical regarding demographic data and the initial symptom scores. In the active-treatment group, 65% responded with a reduction in hot flushes compared with 38% in the placebo group (p<0.006) and, in this group, the number of hot flushes registered in diaries declined after 3 months by 27% as compared to the placebo group (p<0.026). MRS evaluation of hot flushes yielded similar results (p<0.031). There were 23% and 22% decreases in hot flushes after 2 and 3 months of treatment, respectively, and after both intervals of time the inter-group comparisons were significantly affected. An overall evaluation of the trend in 15 other 'quality-of-life' parameters showed likewise in favor of the pollen extract (p<0.031).

CONCLUSION

The pollen extract Femal significantly reduces hot flushes and certain other menopausal symptoms when compared to placebo.

Authors+Show Affiliations

Winther K
Department of Clinical Biochemistry, University Hospital of Copenhagen in Gentofte, Hellerup, Denmark.
Rein E
No affiliation info available
Hedman C
No affiliation info available

MeSH

Blood PressureBody Mass IndexDouble-Blind MethodFemaleFollow-Up StudiesHot FlashesHumansMenopauseMiddle AgedPhytotherapyPlant ExtractsPoaceaePollenQuality of LifeTestosteroneTreatment Outcome

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16096172

Citation

Winther, K, et al. "Femal, a Herbal Remedy Made From Pollen Extracts, Reduces Hot Flushes and Improves Quality of Life in Menopausal Women: a Randomized, Placebo-controlled, Parallel Study." Climacteric : the Journal of the International Menopause Society, vol. 8, no. 2, 2005, pp. 162-70.
Winther K, Rein E, Hedman C. Femal, a herbal remedy made from pollen extracts, reduces hot flushes and improves quality of life in menopausal women: a randomized, placebo-controlled, parallel study. Climacteric. 2005;8(2):162-70.
Winther, K., Rein, E., & Hedman, C. (2005). Femal, a herbal remedy made from pollen extracts, reduces hot flushes and improves quality of life in menopausal women: a randomized, placebo-controlled, parallel study. Climacteric : the Journal of the International Menopause Society, 8(2), 162-70.
Winther K, Rein E, Hedman C. Femal, a Herbal Remedy Made From Pollen Extracts, Reduces Hot Flushes and Improves Quality of Life in Menopausal Women: a Randomized, Placebo-controlled, Parallel Study. Climacteric. 2005;8(2):162-70. PubMed PMID: 16096172.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Femal, a herbal remedy made from pollen extracts, reduces hot flushes and improves quality of life in menopausal women: a randomized, placebo-controlled, parallel study. AU - Winther,K, AU - Rein,E, AU - Hedman,C, PY - 2005/8/13/pubmed PY - 2006/2/10/medline PY - 2005/8/13/entrez SP - 162 EP - 70 JF - Climacteric : the journal of the International Menopause Society JO - Climacteric VL - 8 IS - 2 N2 - BACKGROUND: The fact that hormone replacement therapy has been claimed to increase the risk of breast cancer has made it relevant to search for new non-hormonal treatments of menopausal symptoms. OBJECTIVES: This study aimed to evaluate whether Femal, a herbal remedy made from pollen extracts, alleviates the symptoms of the menopause, especially hot flushes. DESIGN: A randomized, double-blind, placebo-controlled, parallel trial of 64 menopausal women, of whom 54 completed the trial. After an initial run-in phase of 1 month, the women were randomly given either two Femal tablets each morning, or two identical placebo tablets, for 3 months of treatment. On inclusion, and then at 4-week intervals, the patients were asked to evaluate 16 symptoms of the menopause using Menopause Rating Scales (MRS). In addition, every day throughout the study, certain menopausal symptoms were recorded in a diary. RESULTS: The two treatment groups were identical regarding demographic data and the initial symptom scores. In the active-treatment group, 65% responded with a reduction in hot flushes compared with 38% in the placebo group (p<0.006) and, in this group, the number of hot flushes registered in diaries declined after 3 months by 27% as compared to the placebo group (p<0.026). MRS evaluation of hot flushes yielded similar results (p<0.031). There were 23% and 22% decreases in hot flushes after 2 and 3 months of treatment, respectively, and after both intervals of time the inter-group comparisons were significantly affected. An overall evaluation of the trend in 15 other 'quality-of-life' parameters showed likewise in favor of the pollen extract (p<0.031). CONCLUSION: The pollen extract Femal significantly reduces hot flushes and certain other menopausal symptoms when compared to placebo. SN - 1369-7137 UR - https://www.unboundmedicine.com/medline/citation/16096172/Femal_a_herbal_remedy_made_from_pollen_extracts_reduces_hot_flushes_and_improves_quality_of_life_in_menopausal_women:_a_randomized_placebo_controlled_parallel_study_ DB - PRIME DP - Unbound Medicine ER -