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Selective detection of a catecholamine against electroactive interferents using an interdigitated heteroarray electrode consisting of a metal oxide electrode and a metal band electrode.
Anal Chem 2005; 77(16):5236-42AC

Abstract

We developed an interdigitated array electrode (IDAE) consisting of a metal oxide electrode and a metal band heteroelectrode and employed it for the selective detection of catecholamines. We used an indium-tin oxide (ITO) film as the oxidation electrode of the IDAE because the ITO was able to suppress response currents from L-ascorbic acid (AA) and uric acid (UA), which are major electroactive interferents in biological fluids. However, the ITO film also suppresses the reduction of quinones including oxidized catecholamines. We developed a simple technique for fabricating our hetero IDAE, which also preserves the electrochemical properties of the ITO. When we compared hetero ITO-gold, homo ITO-ITO, and carbon-carbon IDAEs, we found that the hetero IDAE provided both high sensitivity and selectivity for DA detection. We achieved high selectivities for DA against AA and UA. The ratios of the response currents of AA and UA to DA were calculated as 6 and 5%, respectively.

Authors+Show Affiliations

NTT Microsystem Integration Laboratories, 3-1 Morinosato, Wakamiya, Atsugi, Kanagawa 243-0198, Japan. kiki@aecl.ntt.co.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16097764

Citation

Hayashi, Katsuyoshi, et al. "Selective Detection of a Catecholamine Against Electroactive Interferents Using an Interdigitated Heteroarray Electrode Consisting of a Metal Oxide Electrode and a Metal Band Electrode." Analytical Chemistry, vol. 77, no. 16, 2005, pp. 5236-42.
Hayashi K, Iwasaki Y, Horiuchi T, et al. Selective detection of a catecholamine against electroactive interferents using an interdigitated heteroarray electrode consisting of a metal oxide electrode and a metal band electrode. Anal Chem. 2005;77(16):5236-42.
Hayashi, K., Iwasaki, Y., Horiuchi, T., Sunagawa, K., & Tate, A. (2005). Selective detection of a catecholamine against electroactive interferents using an interdigitated heteroarray electrode consisting of a metal oxide electrode and a metal band electrode. Analytical Chemistry, 77(16), pp. 5236-42.
Hayashi K, et al. Selective Detection of a Catecholamine Against Electroactive Interferents Using an Interdigitated Heteroarray Electrode Consisting of a Metal Oxide Electrode and a Metal Band Electrode. Anal Chem. 2005 Aug 15;77(16):5236-42. PubMed PMID: 16097764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selective detection of a catecholamine against electroactive interferents using an interdigitated heteroarray electrode consisting of a metal oxide electrode and a metal band electrode. AU - Hayashi,Katsuyoshi, AU - Iwasaki,Yuzuru, AU - Horiuchi,Tsutomu, AU - Sunagawa,Kenji, AU - Tate,Akiyuki, PY - 2005/8/16/pubmed PY - 2007/3/16/medline PY - 2005/8/16/entrez SP - 5236 EP - 42 JF - Analytical chemistry JO - Anal. Chem. VL - 77 IS - 16 N2 - We developed an interdigitated array electrode (IDAE) consisting of a metal oxide electrode and a metal band heteroelectrode and employed it for the selective detection of catecholamines. We used an indium-tin oxide (ITO) film as the oxidation electrode of the IDAE because the ITO was able to suppress response currents from L-ascorbic acid (AA) and uric acid (UA), which are major electroactive interferents in biological fluids. However, the ITO film also suppresses the reduction of quinones including oxidized catecholamines. We developed a simple technique for fabricating our hetero IDAE, which also preserves the electrochemical properties of the ITO. When we compared hetero ITO-gold, homo ITO-ITO, and carbon-carbon IDAEs, we found that the hetero IDAE provided both high sensitivity and selectivity for DA detection. We achieved high selectivities for DA against AA and UA. The ratios of the response currents of AA and UA to DA were calculated as 6 and 5%, respectively. SN - 0003-2700 UR - https://www.unboundmedicine.com/medline/citation/16097764/Selective_detection_of_a_catecholamine_against_electroactive_interferents_using_an_interdigitated_heteroarray_electrode_consisting_of_a_metal_oxide_electrode_and_a_metal_band_electrode L2 - https://dx.doi.org/10.1021/ac050216p DB - PRIME DP - Unbound Medicine ER -