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Five-year follow-up of the Argentine randomized trial of coronary angioplasty with stenting versus coronary bypass surgery in patients with multiple vessel disease (ERACI II).
J Am Coll Cardiol 2005; 46(4):582-8JACC

Abstract

OBJECTIVES

The purpose of the present study is to report the five-year follow-up results of the ERACI II trial.

BACKGROUND

Immediate and one-year follow-up results of the ERACI II study showed a prognosis advantage of percutaneous coronary intervention (PCI) with stents over coronary artery bypass grafting (CABG).

METHODS

A total of 450 patients were randomly assigned to undergo either PCI (n = 225); or CABG (n = 225). Only patients with multi-vessel disease were enrolled. Clinical follow-up during five years was obtained in 92% of the total population after hospital discharge. The primary end point of the study was to compare freedom from major adverse cardiovascular events (MACE) at 30 days, 1 year, 3 years, and 5 years of follow-up.

RESULTS

At five years of follow-up, patients initially treated with PCI had similar survival and freedom from non-fatal acute myocardial infarction than those initially treated with CABG (92.8% vs. 88.4% and 97.3% vs. 94% respectively, p = 0.16). Freedom from repeat revascularization procedures (PCI/CABG) was significantly lower with PCI compared with CABG (71.5% vs. 92.4%, p = 0.0002). Freedom from MACE was also significantly lower with PCI compared with CABG (65.3% vs. 76.4%; p = 0.013). At five years similar numbers of patients randomized to each revascularization procedure were asymptomatic or with class I angina.

CONCLUSIONS

At five years of follow-up, in the ERACI II study, there were no survival benefits from any revascularization procedure; however patients initially treated with CABG had better freedom from repeat revascularization procedures and from MACE.

Authors+Show Affiliations

Otamendi Hospital, Buenos Aires, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16098419

Citation

Rodriguez, Alfredo E., et al. "Five-year Follow-up of the Argentine Randomized Trial of Coronary Angioplasty With Stenting Versus Coronary Bypass Surgery in Patients With Multiple Vessel Disease (ERACI II)." Journal of the American College of Cardiology, vol. 46, no. 4, 2005, pp. 582-8.
Rodriguez AE, Baldi J, Fernández Pereira C, et al. Five-year follow-up of the Argentine randomized trial of coronary angioplasty with stenting versus coronary bypass surgery in patients with multiple vessel disease (ERACI II). J Am Coll Cardiol. 2005;46(4):582-8.
Rodriguez, A. E., Baldi, J., Fernández Pereira, C., Navia, J., Rodriguez Alemparte, M., Delacasa, A., ... Palacios, I. F. (2005). Five-year follow-up of the Argentine randomized trial of coronary angioplasty with stenting versus coronary bypass surgery in patients with multiple vessel disease (ERACI II). Journal of the American College of Cardiology, 46(4), pp. 582-8.
Rodriguez AE, et al. Five-year Follow-up of the Argentine Randomized Trial of Coronary Angioplasty With Stenting Versus Coronary Bypass Surgery in Patients With Multiple Vessel Disease (ERACI II). J Am Coll Cardiol. 2005 Aug 16;46(4):582-8. PubMed PMID: 16098419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Five-year follow-up of the Argentine randomized trial of coronary angioplasty with stenting versus coronary bypass surgery in patients with multiple vessel disease (ERACI II). AU - Rodriguez,Alfredo E, AU - Baldi,Julio, AU - Fernández Pereira,Carlos, AU - Navia,Jose, AU - Rodriguez Alemparte,Máximo, AU - Delacasa,Alejandro, AU - Vigo,Federico, AU - Vogel,Daniel, AU - O'Neill,William, AU - Palacios,Igor F, AU - ,, PY - 2004/10/11/received PY - 2004/12/13/revised PY - 2004/12/20/accepted PY - 2005/8/16/pubmed PY - 2005/9/15/medline PY - 2005/8/16/entrez SP - 582 EP - 8 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 46 IS - 4 N2 - OBJECTIVES: The purpose of the present study is to report the five-year follow-up results of the ERACI II trial. BACKGROUND: Immediate and one-year follow-up results of the ERACI II study showed a prognosis advantage of percutaneous coronary intervention (PCI) with stents over coronary artery bypass grafting (CABG). METHODS: A total of 450 patients were randomly assigned to undergo either PCI (n = 225); or CABG (n = 225). Only patients with multi-vessel disease were enrolled. Clinical follow-up during five years was obtained in 92% of the total population after hospital discharge. The primary end point of the study was to compare freedom from major adverse cardiovascular events (MACE) at 30 days, 1 year, 3 years, and 5 years of follow-up. RESULTS: At five years of follow-up, patients initially treated with PCI had similar survival and freedom from non-fatal acute myocardial infarction than those initially treated with CABG (92.8% vs. 88.4% and 97.3% vs. 94% respectively, p = 0.16). Freedom from repeat revascularization procedures (PCI/CABG) was significantly lower with PCI compared with CABG (71.5% vs. 92.4%, p = 0.0002). Freedom from MACE was also significantly lower with PCI compared with CABG (65.3% vs. 76.4%; p = 0.013). At five years similar numbers of patients randomized to each revascularization procedure were asymptomatic or with class I angina. CONCLUSIONS: At five years of follow-up, in the ERACI II study, there were no survival benefits from any revascularization procedure; however patients initially treated with CABG had better freedom from repeat revascularization procedures and from MACE. SN - 0735-1097 UR - https://www.unboundmedicine.com/medline/citation/16098419/Five_year_follow_up_of_the_Argentine_randomized_trial_of_coronary_angioplasty_with_stenting_versus_coronary_bypass_surgery_in_patients_with_multiple_vessel_disease__ERACI_II__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(05)01170-8 DB - PRIME DP - Unbound Medicine ER -