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The perirhinal cortex of the rat is necessary for spatial memory retention long after but not soon after learning.
Physiol Behav. 2005 Sep 15; 86(1-2):118-27.PB

Abstract

Many observations in humans and experimental animals support the view that the hippocampus is critical immediately after learning in order for long-term memory formation to take place. However, exactly when the medial temporal cortices adjacent to the hippocampus are necessary for this process to occur normally is not yet well known. Using a spatial task, we studied whether the perirhinal cortex of rats is necessary to establish representations in long-term memory. Results showed that, in a spatial task sensitive to hippocampal lesions, control and perirhinal lesioned rats can both learn at the same rate (Experiment 1). Interestingly, a differential involvement of the perirhinal cortex in memory retention was observed as time passes after learning. Thus, 24 days following the end of learning, lesioned and control rats remembered the task perfectly as measured by a retraining test. In contrast, 74 days after the learning the perirhinal animals showed a profound impairment in the retention of the spatial information (Experiment 2). Taken together, these results suggest that the perirhinal region is critical for the formation of long-term spatial memory. However, its contribution to memory formation and retention is time-dependent, it being necessary only long after learning takes place and not during the phase immediately following acquisition.

Authors+Show Affiliations

Departamento de Psicología Experimental y Fisiología del Comportamiento, Facultad de Psicología, Universidad de Granada, Campus de Cartuja, Spain. jmjramos@ugr.esNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16098545

Citation

Ramos, Juan M J., and Joaquín M M. Vaquero. "The Perirhinal Cortex of the Rat Is Necessary for Spatial Memory Retention Long After but Not Soon After Learning." Physiology & Behavior, vol. 86, no. 1-2, 2005, pp. 118-27.
Ramos JM, Vaquero JM. The perirhinal cortex of the rat is necessary for spatial memory retention long after but not soon after learning. Physiol Behav. 2005;86(1-2):118-27.
Ramos, J. M., & Vaquero, J. M. (2005). The perirhinal cortex of the rat is necessary for spatial memory retention long after but not soon after learning. Physiology & Behavior, 86(1-2), 118-27.
Ramos JM, Vaquero JM. The Perirhinal Cortex of the Rat Is Necessary for Spatial Memory Retention Long After but Not Soon After Learning. Physiol Behav. 2005 Sep 15;86(1-2):118-27. PubMed PMID: 16098545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The perirhinal cortex of the rat is necessary for spatial memory retention long after but not soon after learning. AU - Ramos,Juan M J, AU - Vaquero,Joaquín M M, PY - 2005/03/17/received PY - 2005/06/28/revised PY - 2005/07/05/accepted PY - 2005/8/16/pubmed PY - 2005/12/16/medline PY - 2005/8/16/entrez SP - 118 EP - 27 JF - Physiology & behavior JO - Physiol Behav VL - 86 IS - 1-2 N2 - Many observations in humans and experimental animals support the view that the hippocampus is critical immediately after learning in order for long-term memory formation to take place. However, exactly when the medial temporal cortices adjacent to the hippocampus are necessary for this process to occur normally is not yet well known. Using a spatial task, we studied whether the perirhinal cortex of rats is necessary to establish representations in long-term memory. Results showed that, in a spatial task sensitive to hippocampal lesions, control and perirhinal lesioned rats can both learn at the same rate (Experiment 1). Interestingly, a differential involvement of the perirhinal cortex in memory retention was observed as time passes after learning. Thus, 24 days following the end of learning, lesioned and control rats remembered the task perfectly as measured by a retraining test. In contrast, 74 days after the learning the perirhinal animals showed a profound impairment in the retention of the spatial information (Experiment 2). Taken together, these results suggest that the perirhinal region is critical for the formation of long-term spatial memory. However, its contribution to memory formation and retention is time-dependent, it being necessary only long after learning takes place and not during the phase immediately following acquisition. SN - 0031-9384 UR - https://www.unboundmedicine.com/medline/citation/16098545/The_perirhinal_cortex_of_the_rat_is_necessary_for_spatial_memory_retention_long_after_but_not_soon_after_learning_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9384(05)00260-X DB - PRIME DP - Unbound Medicine ER -