Tags

Type your tag names separated by a space and hit enter

Chiari type I malformations in adults: a morphometric analysis of the posterior cranial fossa.
Surg Neurol. 2005 Sep; 64(3):237-41; discussion 241.SN

Abstract

OBJECTIVE

Chiari type I malformation (CMI) is a congenital disorder characterized by caudal displacement of the cerebellar tonsils through the foramen magnum into the spinal canal. Recent studies suggest that overcrowding in the posterior cranial fossa (PCF) because of underdeveloped bony structures in the intrauterine life is the main cause of this malformation. For this reason, the authors want to contribute to the current literature, which focuses on bone abnormalities in the PCF in patients with CMIs.

METHODS

We examined a retrospective cohort of 60 adult patients with CMIs, and multiple measurements were made on magnetic resonance imaging. The results were compared to 30 healthy adult control subjects. Mann-Whitney U test was used as a statistical method.

RESULTS

All measurements except mean anteroposterior diameter of the foramen magnum were reduced in patients compared to control. An increase in the anteroposterior mid-sagittal distance of the foramen magnum in patients reached statistically significant difference compared to control. All patients had tonsillar herniation at least 5 mm below the plane of the foramen magnum. Chiari type I malformation in this study was associated with syringomyelia in 46 patients.

CONCLUSION

This study with a limited number of patients suggests that the bony components of the PCF are not developed fully, supporting the current concept that CMI is a disorder of the para-axial mesoderm.

Authors+Show Affiliations

Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul 34301, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16099255

Citation

Aydin, Sabri, et al. "Chiari Type I Malformations in Adults: a Morphometric Analysis of the Posterior Cranial Fossa." Surgical Neurology, vol. 64, no. 3, 2005, pp. 237-41; discussion 241.
Aydin S, Hanimoglu H, Tanriverdi T, et al. Chiari type I malformations in adults: a morphometric analysis of the posterior cranial fossa. Surg Neurol. 2005;64(3):237-41; discussion 241.
Aydin, S., Hanimoglu, H., Tanriverdi, T., Yentur, E., & Kaynar, M. Y. (2005). Chiari type I malformations in adults: a morphometric analysis of the posterior cranial fossa. Surgical Neurology, 64(3), 237-41; discussion 241.
Aydin S, et al. Chiari Type I Malformations in Adults: a Morphometric Analysis of the Posterior Cranial Fossa. Surg Neurol. 2005;64(3):237-41; discussion 241. PubMed PMID: 16099255.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chiari type I malformations in adults: a morphometric analysis of the posterior cranial fossa. AU - Aydin,Sabri, AU - Hanimoglu,Hakan, AU - Tanriverdi,Taner, AU - Yentur,Ercument, AU - Kaynar,Mehmet Yasar, PY - 2004/07/14/received PY - 2005/02/14/accepted PY - 2005/8/16/pubmed PY - 2005/9/30/medline PY - 2005/8/16/entrez SP - 237-41; discussion 241 JF - Surgical neurology JO - Surg Neurol VL - 64 IS - 3 N2 - OBJECTIVE: Chiari type I malformation (CMI) is a congenital disorder characterized by caudal displacement of the cerebellar tonsils through the foramen magnum into the spinal canal. Recent studies suggest that overcrowding in the posterior cranial fossa (PCF) because of underdeveloped bony structures in the intrauterine life is the main cause of this malformation. For this reason, the authors want to contribute to the current literature, which focuses on bone abnormalities in the PCF in patients with CMIs. METHODS: We examined a retrospective cohort of 60 adult patients with CMIs, and multiple measurements were made on magnetic resonance imaging. The results were compared to 30 healthy adult control subjects. Mann-Whitney U test was used as a statistical method. RESULTS: All measurements except mean anteroposterior diameter of the foramen magnum were reduced in patients compared to control. An increase in the anteroposterior mid-sagittal distance of the foramen magnum in patients reached statistically significant difference compared to control. All patients had tonsillar herniation at least 5 mm below the plane of the foramen magnum. Chiari type I malformation in this study was associated with syringomyelia in 46 patients. CONCLUSION: This study with a limited number of patients suggests that the bony components of the PCF are not developed fully, supporting the current concept that CMI is a disorder of the para-axial mesoderm. SN - 0090-3019 UR - https://www.unboundmedicine.com/medline/citation/16099255/Chiari_type_I_malformations_in_adults:_a_morphometric_analysis_of_the_posterior_cranial_fossa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-3019(05)00135-7 DB - PRIME DP - Unbound Medicine ER -