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The effect of pravastatin on intima media thickness of the carotid artery in patients with normal cholesterol.
Eur J Vasc Endovasc Surg. 2005 Nov; 30(5):464-8.EJ

Abstract

OBJECTIVE

Carotid intima media thickness (IMT) is a good indicator of the severity of atherosclerotic disease. Statins have been found to reduce carotid IMT in patients with hypercholesterolaemia. The aim of this study was to investigate if pravastatin is effective in reducing IMT in normocholesterolaemic patients with carotid artery disease.

METHODS

Patients with carotid artery stenosis and normal cholesterol levels who were not on a statin, were recruited. Patients were randomised to receive pravastatin or placebo daily. Serum concentration of cholesterol and IMT of common carotid arteries were measured before randomisation and at 3 monthly intervals thereafter, for 9 months. IMT was analysed to give the mean of a standardised 2 cm of the common carotid artery (CCA). Results are expressed as median (IQR) and comparison made using the Wilcoxon signed ranks test.

RESULTS

Fifty-four patients were examined. Twenty-eight patients were randomised to active treatment. There was no difference in demographic details and co-morbid states between the two groups. A significant reduction in cholesterol concentration was observed from 3 months in patients randomised to the pravastatin group [5.14(4.72-5.88) vs. 4.11(3.44-5.33), p < 0.05], while there was also a significant decrease in combined IMT form 6 months [1.53(1.36-1.87) vs. 1.41 (1.33-1.78), p < 0.05].

CONCLUSIONS

The results demonstrate that pravastatin reduces intima media thickness of the common carotid artery in normocholesterolaemic patients with moderate carotid stenosis.

Authors+Show Affiliations

Regional Vascular and Endovascular Unit, Belfast City Hospital, Belfast, UK. julieann.reid@virgin.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16099694

Citation

Reid, J A., et al. "The Effect of Pravastatin On Intima Media Thickness of the Carotid Artery in Patients With Normal Cholesterol." European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, vol. 30, no. 5, 2005, pp. 464-8.
Reid JA, Wolsley C, Lau LL, et al. The effect of pravastatin on intima media thickness of the carotid artery in patients with normal cholesterol. Eur J Vasc Endovasc Surg. 2005;30(5):464-8.
Reid, J. A., Wolsley, C., Lau, L. L., Hannon, R. J., Lee, B., Young, I. S., & Soong, C. V. (2005). The effect of pravastatin on intima media thickness of the carotid artery in patients with normal cholesterol. European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, 30(5), 464-8.
Reid JA, et al. The Effect of Pravastatin On Intima Media Thickness of the Carotid Artery in Patients With Normal Cholesterol. Eur J Vasc Endovasc Surg. 2005;30(5):464-8. PubMed PMID: 16099694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of pravastatin on intima media thickness of the carotid artery in patients with normal cholesterol. AU - Reid,J A, AU - Wolsley,C, AU - Lau,L L, AU - Hannon,R J, AU - Lee,B, AU - Young,I S, AU - Soong,C V, PY - 2004/09/12/received PY - 2005/05/09/accepted PY - 2005/8/16/pubmed PY - 2005/12/13/medline PY - 2005/8/16/entrez SP - 464 EP - 8 JF - European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery JO - Eur J Vasc Endovasc Surg VL - 30 IS - 5 N2 - OBJECTIVE: Carotid intima media thickness (IMT) is a good indicator of the severity of atherosclerotic disease. Statins have been found to reduce carotid IMT in patients with hypercholesterolaemia. The aim of this study was to investigate if pravastatin is effective in reducing IMT in normocholesterolaemic patients with carotid artery disease. METHODS: Patients with carotid artery stenosis and normal cholesterol levels who were not on a statin, were recruited. Patients were randomised to receive pravastatin or placebo daily. Serum concentration of cholesterol and IMT of common carotid arteries were measured before randomisation and at 3 monthly intervals thereafter, for 9 months. IMT was analysed to give the mean of a standardised 2 cm of the common carotid artery (CCA). Results are expressed as median (IQR) and comparison made using the Wilcoxon signed ranks test. RESULTS: Fifty-four patients were examined. Twenty-eight patients were randomised to active treatment. There was no difference in demographic details and co-morbid states between the two groups. A significant reduction in cholesterol concentration was observed from 3 months in patients randomised to the pravastatin group [5.14(4.72-5.88) vs. 4.11(3.44-5.33), p < 0.05], while there was also a significant decrease in combined IMT form 6 months [1.53(1.36-1.87) vs. 1.41 (1.33-1.78), p < 0.05]. CONCLUSIONS: The results demonstrate that pravastatin reduces intima media thickness of the common carotid artery in normocholesterolaemic patients with moderate carotid stenosis. SN - 1078-5884 UR - https://www.unboundmedicine.com/medline/citation/16099694/The_effect_of_pravastatin_on_intima_media_thickness_of_the_carotid_artery_in_patients_with_normal_cholesterol_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1078-5884(05)00274-1 DB - PRIME DP - Unbound Medicine ER -