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Donor origin of multipotent adult progenitor cells in radiation chimeras.
Blood. 2005 Nov 15; 106(10):3646-9.Blood

Abstract

Multipotent adult progenitor cells (MAPCs) are bone marrow-derived stem cells that have extensive in vitro expansion capacity and can differentiate in vivo and in vitro into tissue cells of all 3 germinal layers: ectoderm, mesoderm, and endoderm. The origin of MAPCs within bone marrow is unknown. MAPCs are believed to be derived from the bone marrow stroma compartment as they are isolated within the adherent cell component. Numerous studies of bone marrow chimeras in the human and the mouse point to a host origin of bone marrow stromal cells. Mesenchymal stem cells (MSCs), which coexist with stromal cells, have also been proven to be of host origin after allogeneic bone marrow transplantation in numerous studies. We report here that following syngeneic bone marrow transplants into lethally irradiated C57BL6 mice, MAPCs are of donor origin.

Authors+Show Affiliations

Department of Neurology, University of Washington School of Medicine, Seattle, 98195-7720, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16099880

Citation

Reyes, Morayma, et al. "Donor Origin of Multipotent Adult Progenitor Cells in Radiation Chimeras." Blood, vol. 106, no. 10, 2005, pp. 3646-9.
Reyes M, Li S, Foraker J, et al. Donor origin of multipotent adult progenitor cells in radiation chimeras. Blood. 2005;106(10):3646-9.
Reyes, M., Li, S., Foraker, J., Kimura, E., & Chamberlain, J. S. (2005). Donor origin of multipotent adult progenitor cells in radiation chimeras. Blood, 106(10), 3646-9.
Reyes M, et al. Donor Origin of Multipotent Adult Progenitor Cells in Radiation Chimeras. Blood. 2005 Nov 15;106(10):3646-9. PubMed PMID: 16099880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Donor origin of multipotent adult progenitor cells in radiation chimeras. AU - Reyes,Morayma, AU - Li,Sheng, AU - Foraker,Jessica, AU - Kimura,En, AU - Chamberlain,Jeffrey S, Y1 - 2005/08/11/ PY - 2005/8/16/pubmed PY - 2005/12/16/medline PY - 2005/8/16/entrez SP - 3646 EP - 9 JF - Blood JO - Blood VL - 106 IS - 10 N2 - Multipotent adult progenitor cells (MAPCs) are bone marrow-derived stem cells that have extensive in vitro expansion capacity and can differentiate in vivo and in vitro into tissue cells of all 3 germinal layers: ectoderm, mesoderm, and endoderm. The origin of MAPCs within bone marrow is unknown. MAPCs are believed to be derived from the bone marrow stroma compartment as they are isolated within the adherent cell component. Numerous studies of bone marrow chimeras in the human and the mouse point to a host origin of bone marrow stromal cells. Mesenchymal stem cells (MSCs), which coexist with stromal cells, have also been proven to be of host origin after allogeneic bone marrow transplantation in numerous studies. We report here that following syngeneic bone marrow transplants into lethally irradiated C57BL6 mice, MAPCs are of donor origin. SN - 0006-4971 UR - https://www.unboundmedicine.com/medline/citation/16099880/Donor_origin_of_multipotent_adult_progenitor_cells_in_radiation_chimeras_ L2 - https://ashpublications.org/blood/article-lookup/doi/10.1182/blood-2004-12-4603 DB - PRIME DP - Unbound Medicine ER -