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Propofol concentration requirement for laryngeal mask airway insertion was highest with the ProSeal, next highest with the Fastrach, and lowest with the Classic type, with target-controlled infusion.
J Clin Anesth. 2005 Aug; 17(5):344-7.JC

Abstract

STUDY OBJECTIVE

To determine propofol concentration of plasma 50% (Cp50, concentration at which there is a 50% chance that patients show no movement in response) for the Classic-, Fastrach-, and ProSeal-type laryngeal mask airway (LMA) insertion using target-controlled infusion (TCI) technique.

DESIGN

Prospective, randomized, comparative study.

SETTING

University-affiliated hospital.

PATIENTS

Sixty American Society of Anesthesiologists physical status I and II women scheduled for minor gynecologic operations.

INTERVENTIONS

Propofol TCI (Diprifusor pharmacokinetic model) was started at target concentration using an anesthesia pump. After reaching target effect-site concentration of propofol, 1 of the 3 types of LMA was inserted. We recorded patient responses to LMA insertion as "movement" or "no movement." Test propofol concentrations started from a dosage of 4 microg/mL. Concentrations were then predetermined by a modified Dixon's up-and-down method with 0.4 microg/mL step size.

MEASUREMENTS

Patient response to LMA insertion was classified as either of "no movement" or "movement." The midpoint was defined as the average concentration value of crossover (movement/no movement) response. The Cp50 value was defined as the average of the crossover midpoints in each group, and it was estimated from calculating the midpoints.

MAIN RESULTS

Cp50 of the Classic, Fastrach, and ProSeal LMA insertion were 3.2+/-0.34, 4.0+/-0.22, and 4.9+/-0.20 microg/mL (mean+/-SD), respectively.

CONCLUSION

Required propofol TCI concentrations for LMA insertion were significantly highest for the ProSeal, second highest for the Fastrach, and lowest for the Classic LMA.

Authors+Show Affiliations

Department of Anesthesia, Saitama Medical Center, Saitama Medical School, Saitama 350-8550, Japan. pxn01110@nifty.comNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16102683

Citation

Handa-Tsutsui, Fumi, and Mitsuharu Kodaka. "Propofol Concentration Requirement for Laryngeal Mask Airway Insertion Was Highest With the ProSeal, Next Highest With the Fastrach, and Lowest With the Classic Type, With Target-controlled Infusion." Journal of Clinical Anesthesia, vol. 17, no. 5, 2005, pp. 344-7.
Handa-Tsutsui F, Kodaka M. Propofol concentration requirement for laryngeal mask airway insertion was highest with the ProSeal, next highest with the Fastrach, and lowest with the Classic type, with target-controlled infusion. J Clin Anesth. 2005;17(5):344-7.
Handa-Tsutsui, F., & Kodaka, M. (2005). Propofol concentration requirement for laryngeal mask airway insertion was highest with the ProSeal, next highest with the Fastrach, and lowest with the Classic type, with target-controlled infusion. Journal of Clinical Anesthesia, 17(5), 344-7.
Handa-Tsutsui F, Kodaka M. Propofol Concentration Requirement for Laryngeal Mask Airway Insertion Was Highest With the ProSeal, Next Highest With the Fastrach, and Lowest With the Classic Type, With Target-controlled Infusion. J Clin Anesth. 2005;17(5):344-7. PubMed PMID: 16102683.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Propofol concentration requirement for laryngeal mask airway insertion was highest with the ProSeal, next highest with the Fastrach, and lowest with the Classic type, with target-controlled infusion. AU - Handa-Tsutsui,Fumi, AU - Kodaka,Mitsuharu, PY - 2004/01/06/received PY - 2004/08/17/accepted PY - 2005/8/17/pubmed PY - 2005/12/15/medline PY - 2005/8/17/entrez SP - 344 EP - 7 JF - Journal of clinical anesthesia JO - J Clin Anesth VL - 17 IS - 5 N2 - STUDY OBJECTIVE: To determine propofol concentration of plasma 50% (Cp50, concentration at which there is a 50% chance that patients show no movement in response) for the Classic-, Fastrach-, and ProSeal-type laryngeal mask airway (LMA) insertion using target-controlled infusion (TCI) technique. DESIGN: Prospective, randomized, comparative study. SETTING: University-affiliated hospital. PATIENTS: Sixty American Society of Anesthesiologists physical status I and II women scheduled for minor gynecologic operations. INTERVENTIONS: Propofol TCI (Diprifusor pharmacokinetic model) was started at target concentration using an anesthesia pump. After reaching target effect-site concentration of propofol, 1 of the 3 types of LMA was inserted. We recorded patient responses to LMA insertion as "movement" or "no movement." Test propofol concentrations started from a dosage of 4 microg/mL. Concentrations were then predetermined by a modified Dixon's up-and-down method with 0.4 microg/mL step size. MEASUREMENTS: Patient response to LMA insertion was classified as either of "no movement" or "movement." The midpoint was defined as the average concentration value of crossover (movement/no movement) response. The Cp50 value was defined as the average of the crossover midpoints in each group, and it was estimated from calculating the midpoints. MAIN RESULTS: Cp50 of the Classic, Fastrach, and ProSeal LMA insertion were 3.2+/-0.34, 4.0+/-0.22, and 4.9+/-0.20 microg/mL (mean+/-SD), respectively. CONCLUSION: Required propofol TCI concentrations for LMA insertion were significantly highest for the ProSeal, second highest for the Fastrach, and lowest for the Classic LMA. SN - 0952-8180 UR - https://www.unboundmedicine.com/medline/citation/16102683/Propofol_concentration_requirement_for_laryngeal_mask_airway_insertion_was_highest_with_the_ProSeal_next_highest_with_the_Fastrach_and_lowest_with_the_Classic_type_with_target_controlled_infusion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-8180(05)00134-0 DB - PRIME DP - Unbound Medicine ER -