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Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging.
Mol Aspects Med. 2005 Aug-Oct; 26(4-5):363-78.MA

Abstract

Mitochondrial oxidative decay, which is a major contributor to aging, is accelerated by many common micronutrient deficiencies. One major mechanism is inhibition of the pathway of heme biosynthesis in mitochondria, which causes a deficit of heme-a. Heme-a, only found in Complex IV, is selectively diminished, resulting in oxidant leakage and accelerated mitochondrial decay, which leads to DNA damage, neural decay, and aging. We emphasize those deficiencies, which appear to cause damage through this mechanism, particularly minerals such as iron (25% of menstruating women ingest <50% of the RDA) or zinc (10% of the population ingest <50% of the RDA). Several vitamin deficiencies, such as biotin or pantothenic acid, also increase mitochondrial oxidants through this mechanism. Additionally, other minerals such as magnesium and manganese that play a role in mitochondrial metabolism, but do not affect heme directly, are discussed. An optimum intake of micronutrients could tune up metabolism and give a marked increase in health, particularly for the poor, elderly, and obese, at little cost.

Authors+Show Affiliations

Nutrition, Metabolisms and Genomics Center, Children's Hospital Oakland Research Institute, Oakland, CA 94609, U States. bames@chori.orgNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

16102804

Citation

Ames, Bruce N., et al. "Mineral and Vitamin Deficiencies Can Accelerate the Mitochondrial Decay of Aging." Molecular Aspects of Medicine, vol. 26, no. 4-5, 2005, pp. 363-78.
Ames BN, Atamna H, Killilea DW. Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging. Mol Aspects Med. 2005;26(4-5):363-78.
Ames, B. N., Atamna, H., & Killilea, D. W. (2005). Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging. Molecular Aspects of Medicine, 26(4-5), 363-78.
Ames BN, Atamna H, Killilea DW. Mineral and Vitamin Deficiencies Can Accelerate the Mitochondrial Decay of Aging. Mol Aspects Med. 2005 Aug-Oct;26(4-5):363-78. PubMed PMID: 16102804.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging. AU - Ames,Bruce N, AU - Atamna,Hani, AU - Killilea,David W, PY - 2005/8/17/pubmed PY - 2005/11/5/medline PY - 2005/8/17/entrez SP - 363 EP - 78 JF - Molecular aspects of medicine JO - Mol Aspects Med VL - 26 IS - 4-5 N2 - Mitochondrial oxidative decay, which is a major contributor to aging, is accelerated by many common micronutrient deficiencies. One major mechanism is inhibition of the pathway of heme biosynthesis in mitochondria, which causes a deficit of heme-a. Heme-a, only found in Complex IV, is selectively diminished, resulting in oxidant leakage and accelerated mitochondrial decay, which leads to DNA damage, neural decay, and aging. We emphasize those deficiencies, which appear to cause damage through this mechanism, particularly minerals such as iron (25% of menstruating women ingest <50% of the RDA) or zinc (10% of the population ingest <50% of the RDA). Several vitamin deficiencies, such as biotin or pantothenic acid, also increase mitochondrial oxidants through this mechanism. Additionally, other minerals such as magnesium and manganese that play a role in mitochondrial metabolism, but do not affect heme directly, are discussed. An optimum intake of micronutrients could tune up metabolism and give a marked increase in health, particularly for the poor, elderly, and obese, at little cost. SN - 0098-2997 UR - https://www.unboundmedicine.com/medline/citation/16102804/Mineral_and_vitamin_deficiencies_can_accelerate_the_mitochondrial_decay_of_aging_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0098-2997(05)00041-5 DB - PRIME DP - Unbound Medicine ER -