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Acute stress exposure prior to influenza vaccination enhances antibody response in women.
Brain Behav Immun. 2006 Mar; 20(2):159-68.BB

Abstract

Animal studies have shown that an acute stressor in close temporal proximity to immune challenge can enhance the response to delayed-type hypersensitivity and antibody response to vaccination. The current study examined the effects of acute exercise or mental stress prior to influenza vaccination on the subsequent antibody response to each of the three viral strains. Sixty young healthy adults (31 men, 29 women) were randomly allocated to one of three task conditions: dynamic exercise, mental stress, or control. After an initial baseline, participants completed their allocated 45 min task and then received the influenza vaccine. Plasma cortisol and interleukin-6 were determined at the end of baseline, after the task, and after 60 min recovery. Antibody titres were measured pre-vaccination and at 4 weeks and 20 weeks post-vaccination follow-ups. For the A/Panama strain, women in both the exercise and mental stress conditions showed higher antibody titres at both 4 and 20 weeks than those in the control condition, while men responded similarly in all conditions. Interleukin-6 at +60 min recovery was found to be a significant predictor of subsequent A/Panama antibody response in women. In line with animal research, the current study provides preliminary evidence that acute stress can enhance the antibody response to vaccination in humans.

Authors+Show Affiliations

Edwards KM
School of Sport and Exercise Sciences, University of Birmingham, UK. kxe222@bham.ac.uk
Burns VE
No affiliation info available
Reynolds T
No affiliation info available
Carroll D
No affiliation info available
Drayson M
No affiliation info available
Ring C
No affiliation info available

MeSH

Acute DiseaseAdultAnalysis of VarianceAntibody FormationFemaleHumansHydrocortisoneInfluenza A virusInfluenza B virusInfluenza VaccinesInterleukin-6MalePhysical ExertionReference ValuesSex FactorsStress, Physiological

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16102936

Clinical Trial Links

Do NSAIDS or Executing Exercise Decrease Local Erythema, Site Swelling & Pain After INoculation

Citation

Edwards, Kate M., et al. "Acute Stress Exposure Prior to Influenza Vaccination Enhances Antibody Response in Women." Brain, Behavior, and Immunity, vol. 20, no. 2, 2006, pp. 159-68.
Edwards KM, Burns VE, Reynolds T, et al. Acute stress exposure prior to influenza vaccination enhances antibody response in women. Brain Behav Immun. 2006;20(2):159-68.
Edwards, K. M., Burns, V. E., Reynolds, T., Carroll, D., Drayson, M., & Ring, C. (2006). Acute stress exposure prior to influenza vaccination enhances antibody response in women. Brain, Behavior, and Immunity, 20(2), 159-68.
Edwards KM, et al. Acute Stress Exposure Prior to Influenza Vaccination Enhances Antibody Response in Women. Brain Behav Immun. 2006;20(2):159-68. PubMed PMID: 16102936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute stress exposure prior to influenza vaccination enhances antibody response in women. AU - Edwards,Kate M, AU - Burns,Victoria E, AU - Reynolds,Tracy, AU - Carroll,Douglas, AU - Drayson,Mark, AU - Ring,Christopher, Y1 - 2005/08/15/ PY - 2005/05/09/received PY - 2005/06/30/revised PY - 2005/07/06/accepted PY - 2005/8/17/pubmed PY - 2006/4/19/medline PY - 2005/8/17/entrez SP - 159 EP - 68 JF - Brain, behavior, and immunity JO - Brain Behav Immun VL - 20 IS - 2 N2 - Animal studies have shown that an acute stressor in close temporal proximity to immune challenge can enhance the response to delayed-type hypersensitivity and antibody response to vaccination. The current study examined the effects of acute exercise or mental stress prior to influenza vaccination on the subsequent antibody response to each of the three viral strains. Sixty young healthy adults (31 men, 29 women) were randomly allocated to one of three task conditions: dynamic exercise, mental stress, or control. After an initial baseline, participants completed their allocated 45 min task and then received the influenza vaccine. Plasma cortisol and interleukin-6 were determined at the end of baseline, after the task, and after 60 min recovery. Antibody titres were measured pre-vaccination and at 4 weeks and 20 weeks post-vaccination follow-ups. For the A/Panama strain, women in both the exercise and mental stress conditions showed higher antibody titres at both 4 and 20 weeks than those in the control condition, while men responded similarly in all conditions. Interleukin-6 at +60 min recovery was found to be a significant predictor of subsequent A/Panama antibody response in women. In line with animal research, the current study provides preliminary evidence that acute stress can enhance the antibody response to vaccination in humans. SN - 0889-1591 UR - https://www.unboundmedicine.com/medline/citation/16102936/Acute_stress_exposure_prior_to_influenza_vaccination_enhances_antibody_response_in_women_ DB - PRIME DP - Unbound Medicine ER -