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Maternal diet and acute lymphoblastic leukemia in young children.

Abstract

Because leukemia clone-specific chromosomal abnormalities are present at birth in children who later develop leukemia, it has been hypothesized that maternal factors, including nutrition during pregnancy, might affect the risk of acute lymphoblastic leukemia (ALL) among young children. We have evaluated this hypothesis in a nationwide case-control study of ALL among children ages 12 to 59 months in Greece. Children (n=131) with ALL were gender and age matched to control children (n=131) hospitalized for minor conditions between 1999 and 2003. The mothers of the children were interviewed in person by trained interviewers who used an extensive food frequency questionnaire addressing diet during the index pregnancy. The analysis was done by modeling the data through conditional logistic regression, also controlling for total energy intake and possible confounding factors. Odds ratios (OR) and 95% confidence intervals (95% CI) were expressed per quintile increase of maternal intake during pregnancy of the specified food group. The risk of ALL in the offspring was lower with increased maternal intake of fruits (OR, 0.72; 95% CI, 0.57-0.91), vegetables (OR, 0.76; 95% CI, 0.60-0.95), and fish and seafood (OR, 0.72; 95% CI, 0.59-0.89) and higher with increased maternal intake of sugars and syrups (OR, 1.32; 95% CI, 1.05-1.67) and meat and meat products (OR, 1.25; 95% CI, 1.00-1.57). Children of women who tend to consume during their pregnancies what is currently considered to be a healthy diet maybe at lower risk of ALL.

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  • Authors+Show Affiliations

    ,

    Department of Hygiene and Epidemiology, Athens University Medical School, 75 Mikras Asias str., Goudi, Athens 115-27, Greece. epetrid@med.uoa.gr

    , , , ,

    Source

    MeSH

    Case-Control Studies
    Child, Preschool
    Diet
    Female
    Greece
    Humans
    Infant
    Logistic Models
    Male
    Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Pregnancy
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    16103440

    Citation

    Petridou, Eleni, et al. "Maternal Diet and Acute Lymphoblastic Leukemia in Young Children." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 14, no. 8, 2005, pp. 1935-9.
    Petridou E, Ntouvelis E, Dessypris N, et al. Maternal diet and acute lymphoblastic leukemia in young children. Cancer Epidemiol Biomarkers Prev. 2005;14(8):1935-9.
    Petridou, E., Ntouvelis, E., Dessypris, N., Terzidis, A., & Trichopoulos, D. (2005). Maternal diet and acute lymphoblastic leukemia in young children. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 14(8), pp. 1935-9.
    Petridou E, et al. Maternal Diet and Acute Lymphoblastic Leukemia in Young Children. Cancer Epidemiol Biomarkers Prev. 2005;14(8):1935-9. PubMed PMID: 16103440.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Maternal diet and acute lymphoblastic leukemia in young children. AU - Petridou,Eleni, AU - Ntouvelis,Evangelos, AU - Dessypris,Nick, AU - Terzidis,Agapios, AU - Trichopoulos,Dimitrios, AU - ,, PY - 2005/8/17/pubmed PY - 2005/11/9/medline PY - 2005/8/17/entrez SP - 1935 EP - 9 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 14 IS - 8 N2 - Because leukemia clone-specific chromosomal abnormalities are present at birth in children who later develop leukemia, it has been hypothesized that maternal factors, including nutrition during pregnancy, might affect the risk of acute lymphoblastic leukemia (ALL) among young children. We have evaluated this hypothesis in a nationwide case-control study of ALL among children ages 12 to 59 months in Greece. Children (n=131) with ALL were gender and age matched to control children (n=131) hospitalized for minor conditions between 1999 and 2003. The mothers of the children were interviewed in person by trained interviewers who used an extensive food frequency questionnaire addressing diet during the index pregnancy. The analysis was done by modeling the data through conditional logistic regression, also controlling for total energy intake and possible confounding factors. Odds ratios (OR) and 95% confidence intervals (95% CI) were expressed per quintile increase of maternal intake during pregnancy of the specified food group. The risk of ALL in the offspring was lower with increased maternal intake of fruits (OR, 0.72; 95% CI, 0.57-0.91), vegetables (OR, 0.76; 95% CI, 0.60-0.95), and fish and seafood (OR, 0.72; 95% CI, 0.59-0.89) and higher with increased maternal intake of sugars and syrups (OR, 1.32; 95% CI, 1.05-1.67) and meat and meat products (OR, 1.25; 95% CI, 1.00-1.57). Children of women who tend to consume during their pregnancies what is currently considered to be a healthy diet maybe at lower risk of ALL. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/16103440/full_citation L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=16103440 DB - PRIME DP - Unbound Medicine ER -