Tags

Type your tag names separated by a space and hit enter

Chiral aminonaphthol-catalyzed enantioselective carbonyl addition of diethylzinc to aromatic aldehydes high-throughput screened by CD-HPLC analysis.
Chirality. 2005 Oct; 17(8):476-80.C

Abstract

Optically active aminonaphthols derivatives are obtained by condensation of 2-naphthol, substituted benzaldehyde, and (S)-methylbenzylamine under mild conditions, without side products. Their absolute configurations are determined by X-ray crystallographic analysis. The addition of diethylzinc to aromatic aldehydes is considerably accelerated by the presence of a catalytic amount of crystalline to give, after hydrolysis, the corresponding 1-phenylpropanol in good enantiomeric purity, as determined by CD-HPLC analysis as HTPS (high-throughput screening).

Authors+Show Affiliations

Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo 152-8552, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16104027

Citation

Xu, Ling, et al. "Chiral Aminonaphthol-catalyzed Enantioselective Carbonyl Addition of Diethylzinc to Aromatic Aldehydes High-throughput Screened By CD-HPLC Analysis." Chirality, vol. 17, no. 8, 2005, pp. 476-80.
Xu L, Shen X, Zhang C, et al. Chiral aminonaphthol-catalyzed enantioselective carbonyl addition of diethylzinc to aromatic aldehydes high-throughput screened by CD-HPLC analysis. Chirality. 2005;17(8):476-80.
Xu, L., Shen, X., Zhang, C., & Mikami, K. (2005). Chiral aminonaphthol-catalyzed enantioselective carbonyl addition of diethylzinc to aromatic aldehydes high-throughput screened by CD-HPLC analysis. Chirality, 17(8), 476-80.
Xu L, et al. Chiral Aminonaphthol-catalyzed Enantioselective Carbonyl Addition of Diethylzinc to Aromatic Aldehydes High-throughput Screened By CD-HPLC Analysis. Chirality. 2005;17(8):476-80. PubMed PMID: 16104027.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chiral aminonaphthol-catalyzed enantioselective carbonyl addition of diethylzinc to aromatic aldehydes high-throughput screened by CD-HPLC analysis. AU - Xu,Ling, AU - Shen,Xiumin, AU - Zhang,Cong, AU - Mikami,Koichi, PY - 2005/8/17/pubmed PY - 2005/12/20/medline PY - 2005/8/17/entrez SP - 476 EP - 80 JF - Chirality JO - Chirality VL - 17 IS - 8 N2 - Optically active aminonaphthols derivatives are obtained by condensation of 2-naphthol, substituted benzaldehyde, and (S)-methylbenzylamine under mild conditions, without side products. Their absolute configurations are determined by X-ray crystallographic analysis. The addition of diethylzinc to aromatic aldehydes is considerably accelerated by the presence of a catalytic amount of crystalline to give, after hydrolysis, the corresponding 1-phenylpropanol in good enantiomeric purity, as determined by CD-HPLC analysis as HTPS (high-throughput screening). SN - 0899-0042 UR - https://www.unboundmedicine.com/medline/citation/16104027/Chiral_aminonaphthol_catalyzed_enantioselective_carbonyl_addition_of_diethylzinc_to_aromatic_aldehydes_high_throughput_screened_by_CD_HPLC_analysis_ L2 - https://doi.org/10.1002/chir.20183 DB - PRIME DP - Unbound Medicine ER -