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Mothers in stress: consequences for the offspring.
Am J Reprod Immunol 2005; 54(2):63-9AJ

Abstract

No memories exist on one's time before birth. However, this does not imply that the developing fetus is not susceptible to external impulses. On the contrary, the fetus is extremely vulnerable e.g. to environmental challenges, and a wealth of data reveals that conditions in utero affect the health of the fetus before and after birth. Threats for the growing fetus include psychological challenges perceived by the mother, e.g. high levels of stress during pregnancy. However, stress experienced during pregnancy not only leads to pregnancy complications like miscarriage, pre-eclampsia, preterm parturition, low birth weight or major congenital malformations, stress also increases the risk of the child to develop diseases in the subsequent periods of life. This condition is termed fetal programming of adult disease. Programming agents seem to include growth factors, cytokines and hormones, all of which can be altered by stress. As a consequence, such 'stress-modified' systems of the offspring are more susceptible to environmental influences during later life, e.g. the development of atopic diseases upon exposure to antigens. The present review illuminates the complexity of stress perception on fetal programming focusing predominately on the onset of atopic diseases on the background of published evidence from immunology, endocrinology, neurobiology and neonatology.

Authors+Show Affiliations

Department of Pediatrics for Pneumology and Immunology, University Medicine Charité, Berlin, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16105097

Citation

Knackstedt, Maike Katharina, et al. "Mothers in Stress: Consequences for the Offspring." American Journal of Reproductive Immunology (New York, N.Y. : 1989), vol. 54, no. 2, 2005, pp. 63-9.
Knackstedt MK, Hamelmann E, Arck PC. Mothers in stress: consequences for the offspring. Am J Reprod Immunol. 2005;54(2):63-9.
Knackstedt, M. K., Hamelmann, E., & Arck, P. C. (2005). Mothers in stress: consequences for the offspring. American Journal of Reproductive Immunology (New York, N.Y. : 1989), 54(2), pp. 63-9.
Knackstedt MK, Hamelmann E, Arck PC. Mothers in Stress: Consequences for the Offspring. Am J Reprod Immunol. 2005;54(2):63-9. PubMed PMID: 16105097.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mothers in stress: consequences for the offspring. AU - Knackstedt,Maike Katharina, AU - Hamelmann,Eckard, AU - Arck,Petra Clara, PY - 2005/8/18/pubmed PY - 2005/9/30/medline PY - 2005/8/18/entrez SP - 63 EP - 9 JF - American journal of reproductive immunology (New York, N.Y. : 1989) JO - Am. J. Reprod. Immunol. VL - 54 IS - 2 N2 - No memories exist on one's time before birth. However, this does not imply that the developing fetus is not susceptible to external impulses. On the contrary, the fetus is extremely vulnerable e.g. to environmental challenges, and a wealth of data reveals that conditions in utero affect the health of the fetus before and after birth. Threats for the growing fetus include psychological challenges perceived by the mother, e.g. high levels of stress during pregnancy. However, stress experienced during pregnancy not only leads to pregnancy complications like miscarriage, pre-eclampsia, preterm parturition, low birth weight or major congenital malformations, stress also increases the risk of the child to develop diseases in the subsequent periods of life. This condition is termed fetal programming of adult disease. Programming agents seem to include growth factors, cytokines and hormones, all of which can be altered by stress. As a consequence, such 'stress-modified' systems of the offspring are more susceptible to environmental influences during later life, e.g. the development of atopic diseases upon exposure to antigens. The present review illuminates the complexity of stress perception on fetal programming focusing predominately on the onset of atopic diseases on the background of published evidence from immunology, endocrinology, neurobiology and neonatology. SN - 1046-7408 UR - https://www.unboundmedicine.com/medline/citation/16105097/Mothers_in_stress:_consequences_for_the_offspring_ L2 - https://doi.org/10.1111/j.1600-0897.2005.00288.x DB - PRIME DP - Unbound Medicine ER -