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Mimivirus relatives in the Sargasso sea.
Virol J. 2005 Aug 16; 2:62.VJ

Abstract

The discovery and genome analysis of Acanthamoeba polyphaga Mimivirus, the largest known DNA virus, challenged much of the accepted dogma regarding viruses. Its particle size (>400 nm), genome length (1.2 million bp) and huge gene repertoire (911 protein coding genes) all contribute to blur the established boundaries between viruses and the smallest parasitic cellular organisms. Phylogenetic analyses also suggested that the Mimivirus lineage could have emerged prior to the individualization of cellular organisms from the three established domains, triggering a debate that can only be resolved by generating and analyzing more data. The next step is then to seek some evidence that Mimivirus is not the only representative of its kind and determine where to look for new Mimiviridae. An exhaustive similarity search of all Mimivirus predicted proteins against all publicly available sequences identified many of their closest homologues among the Sargasso Sea environmental sequences. Subsequent phylogenetic analyses suggested that unknown large viruses evolutionarily closer to Mimivirus than to any presently characterized species exist in abundance in the Sargasso Sea. Their isolation and genome sequencing could prove invaluable in understanding the origin and diversity of large DNA viruses, and shed some light on the role they eventually played in the emergence of eukaryotes.

Authors+Show Affiliations

Department of Parasite and Virus Genomics, The Institute for Genomic Research, Rockville, MD 20850, USA. eghdin@tigr.orgNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16105173

Citation

Ghedin, Elodie, and Jean-Michel Claverie. "Mimivirus Relatives in the Sargasso Sea." Virology Journal, vol. 2, 2005, p. 62.
Ghedin E, Claverie JM. Mimivirus relatives in the Sargasso sea. Virol J. 2005;2:62.
Ghedin, E., & Claverie, J. M. (2005). Mimivirus relatives in the Sargasso sea. Virology Journal, 2, 62.
Ghedin E, Claverie JM. Mimivirus Relatives in the Sargasso Sea. Virol J. 2005 Aug 16;2:62. PubMed PMID: 16105173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mimivirus relatives in the Sargasso sea. AU - Ghedin,Elodie, AU - Claverie,Jean-Michel, Y1 - 2005/08/16/ PY - 2005/05/01/received PY - 2005/08/16/accepted PY - 2005/8/18/pubmed PY - 2005/8/18/medline PY - 2005/8/18/entrez SP - 62 EP - 62 JF - Virology journal JO - Virol J VL - 2 N2 - The discovery and genome analysis of Acanthamoeba polyphaga Mimivirus, the largest known DNA virus, challenged much of the accepted dogma regarding viruses. Its particle size (>400 nm), genome length (1.2 million bp) and huge gene repertoire (911 protein coding genes) all contribute to blur the established boundaries between viruses and the smallest parasitic cellular organisms. Phylogenetic analyses also suggested that the Mimivirus lineage could have emerged prior to the individualization of cellular organisms from the three established domains, triggering a debate that can only be resolved by generating and analyzing more data. The next step is then to seek some evidence that Mimivirus is not the only representative of its kind and determine where to look for new Mimiviridae. An exhaustive similarity search of all Mimivirus predicted proteins against all publicly available sequences identified many of their closest homologues among the Sargasso Sea environmental sequences. Subsequent phylogenetic analyses suggested that unknown large viruses evolutionarily closer to Mimivirus than to any presently characterized species exist in abundance in the Sargasso Sea. Their isolation and genome sequencing could prove invaluable in understanding the origin and diversity of large DNA viruses, and shed some light on the role they eventually played in the emergence of eukaryotes. SN - 1743-422X UR - https://www.unboundmedicine.com/medline/citation/16105173/Mimivirus_relatives_in_the_Sargasso_sea_ L2 - https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-62 DB - PRIME DP - Unbound Medicine ER -